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13:39ENDemis Hassabis on Digital Biology, AlphaFold and the Limits of Classical ComputingMatthew Berman, Demis Hassabis · Forward FutureMatthew Berman reviews Hassabis’s Nobel lecture on protein structure, AI-driven discovery and a speculative question about what classical learning algorithms can model.
27:07ENAfter adding $100 billion a month, Jensen Huang says NVIDIA is selling the data centerホスト Sarah Guo, Elad GilSarah Guo and Elad Gil clip their favorite 2024 No Priors conversations into a year-end reel of NVIDIA, Karpathy, Sierra, Sora, Waymo, Figma, and Scale.
1:49ENWhy Two Slits Create Bright and Dark Interference FringesA short wave model explains why adding a second path can darken some points on a screen.
2:11:15ENA 50% Chance of Extinction — and a $50 GPT-4 for Everyoneホスト Nathan LabenzEmad Mostaque tells Nathan Labenz why he puts p(doom) at even odds, why a five-watt model changes the energy debate, and how the Intelligent Internet would fund universal basic AI with a Bitcoin-like token.
21:02ENReactions to OpenAI’s 2024 o3 Preview: Benchmarks, Cost and LimitsMatthew Berman · Forward FutureMatthew Berman surveys the responses to the o3 preview, from mathematical benchmarks to debates about AGI, compute and reliability.
3:26:39ENThe Pessimism Line: Why Earth Is Almost Certainly Not the First Civilizationゲスト Adam Frank · ホスト Lex FridmanAstrophysicist Adam Frank talks with Lex Fridman about habitable worlds, the Fermi paradox, technosignatures, and why science cannot ignore experience.
1:32:14ZH李广密:AI 任务引擎、模型竞争与 2025 年的 Agent 预测ゲスト 李广密 · ホスト 张小珺在 2024 年末,李广密与张小珺讨论 AI 如何改变搜索、编程和软件,以及模型公司面临的竞争与数据约束。
14:15ENAnthropic’s Alignment Faking Study: What the Experiments Actually ShowMatthew Berman · Forward FutureMatthew Berman examines a 2024 study of models responding differently when they believe their answers will be used for training.
1:46:41ENFrontier Models Hit the 10th–40th Percentile on Real AI R&Dホスト Nathan LabenzNeev Parikh of METR walks Nathan Labenz through REBench, a seven-task test of whether agents can do machine learning research—and what happened when one of them decided not to train.
1:10:55ENMatt Plank on Building Rippling’s Sales Organization and Scaling Outboundゲスト Matt Plank · ホスト Harry StebbingsThe Rippling CRO explains how his team plans capacity, works with marketing, prices deals and adapts its sales model as the product portfolio grows.
26:23ENOpenAI’s o3 Announcement: Benchmark Gains and the Question of AGIMatthew Berman, Sam Altman, Mark Chen, Greg Kamradt, Hongyu Ren · Forward FutureMatthew Berman reviews the December 2024 o3 and o3-mini announcement, including coding, math and ARC-AGI results. He calls the results evidence of AGI, a conclusion the benchmarks alone cannot establish.
12:43ENHow OCaml Represents Values in MemoryA practical tour of immediate integers, heap blocks, runtime tags and variant constructors, illustrated with OCaml's Obj module.
9:00ENBest-of-N Jailbreaking: What Repeated Prompt Variations Revealed in 2024Matthew Berman · Forward FutureMatthew Berman reviews research on how repeated input variations can expose safety failures in text, vision and audio models.
2:10ENFive Enterprise AI Predictions for 2025Matthew Berman · Forward FutureMatthew Berman summarizes an Informatica executive’s late-2024 outlook on agents, regulation, workforce skills, return on investment and security.
13:31ENGoogle Veo 2: Cinematic Controls, Realistic Scenes and Motion LimitsMatthew Berman · Forward FutureMatthew Berman reviews Google’s 2024 video-generation examples, compares selected outputs with Sora and points out where movement or prompt adherence breaks down.
31:18ENElias Torres sold a billion-dollar company and called it a failure. Agency is the redo.ホスト Sarah Guo, Elad GilThe Drift founder wants $1 billion in revenue with 100 people, one email address, and software that works like a text to someone who actually shows up.
1:01:53ENHumans Wrote 1.3 Percent of the Tokens. The AI Lab Still Designed Working Nanobodies.ホスト Nathan LabenzStanford's James Zou describes a GPT-4o research group that invented a protein-design pipeline for under $100 — and a sparse autoencoder that pulled an undocumented motif out of ESM-2.
1:07:32ENo1 Is a New Generation — and the Day AGI Arrives Will Feel Boringホスト Jacob EffronOpenAI’s former chief research officer Bob McGrew on why o1 is a 100x leap, why agents stall on reliability, and why AGI may land as office tedium rather than a single dramatic moment.
1:06:43ENDaniel Dines on Why AI Agents Need Workflow Automationゲスト Daniel Dines · ホスト Harry StebbingsThe UiPath founder explains why he expects rule-based automation, agents and human validation to coexist—and reflects on the demands of leading through an AI transition.
1:01:48ENReid Hoffman on Trade, AI, Energy and the Incoming Trump Administrationゲスト Reid Hoffman · ホスト Harry StebbingsThe investor discusses political risks and opportunities, competition in AI, nuclear energy and the role of venture capital in a wide-ranging December 2024 interview.
55:50ENThere will not be one model. Fireworks is betting on hundreds of small expertsホスト Jacob EffronPyTorch veteran Lin Qiao argues that inference is a compound system hyperscalers cannot buy their way through, and that the products with real traction still keep a human in the loop.
52:11ZHKevin Xu:从奥巴马竞选到 2024 年大选,候选人如何与时代匹配ゲスト Kevin Xu · ホスト 张小珺一名前竞选工作人员回顾地推、竞选组织与白宫新闻工作,并分享他对 2024 年选举及科技政治关系的观察。
1:13:42ENGuillaume Moubeche on Bootstrapping lemlist Through Sales and Contentゲスト Guillaume Moubeche · ホスト Harry StebbingsThe lempire founder describes the early sales work, product mistakes and content strategy behind a bootstrapped software business.
42:21ENThey Cooled 5,000 Watts per Square Centimeter in Space. Now Diamond Goes on AI Chipsホスト Sarah Guo, Elad GilAkash Systems founders Felix Ejeckam and Ty Mitchell tell Sarah Guo why heat is the real limiter on AI, and how lab-grown diamond bonded to semiconductors is their answer.
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