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21:52ENJosef Witt-Doerring on Gen Z Mental Health, Isolation, and Psychiatric PrescribingShabbos Kestenbaum, Josef Witt-Doerring, Scott Galloway · PragerUOn The Brief, Shabbos Kestenbaum and psychiatrist Josef Witt-Doerring discuss why young adults are struggling, how prescribing incentives shape care, and the place of relationships and daily habits in treatment.
3:36:56ENPsychiatry Has Never Found Its PenicillinPresenta: Lex FridmanHistorian Andrew Scull tells Lex Fridman why the field can ease symptoms, has never cured a major mental illness, and keeps paying for overconfidence with patients' lives.
1:25:13ENA $500 Lamp Cut TB Transmission 90 Percent. Almost Nobody Buys OnePresenta: Nathan LabenzAerolamp's Misha Gurevich and Vivian Belenky walk Patrick McKenzie through far-UVC at 222 nanometers: the lab science, the safety case, and why the bottleneck is awareness rather than physics.
2:06:09ENOne ChatGPT query is a second in the microwavePresenta: Nathan LabenzAndy Masley walks Nathan Labenz through the energy and water math of AI, from a single prompt to an 80-gigawatt buildout.
1:29:30EN2,500 Compounds and a 51 Percent Hit Rate: How a Small Graph Net Found New AntibioticsPresenta: Nathan LabenzMIT's Jim Collins tells Nathan Labenz how a bootlegged 2018 project, a binary growth-inhibition label, and Chemprop graph networks pulled novel antibiotics out of chemical space that labs could never screen by hand.
27:12ENWhy Rick Caruso's Palisades Village Stood While Two Manhattans BurnedPresenta: Sarah Guo, Elad GilThe Los Angeles developer and former mayoral candidate on empty hydrants, 40 years of uncut brush, and rebuilding in a year instead of a decade.
37:58ENThe Forest Will Burn. The Only Question Is on Whose Terms.Presenta: Sarah Guo, Elad GilConvective Capital’s Bill Clerico walks through why California’s wildfires reached a crescendo, and which wounds are still self-inflicted enough to fix.
1:02:32ENThe More Important the Issue, the Less Anyone Discusses ItPresenta: Lex FridmanBernie Sanders tells Lex Fridman why drug lobbyists, campaign cash, and a healthcare system built for profit keep the biggest American problems off the table.
1:47:18ENA Cannabis Clip Sat Quiet for a Year. Then It Hit X.Invitado: Andrew Huberman · Presenta: Lex FridmanAndrew Huberman talks with Lex Fridman about online pile-ons, still minds, sharks, ayahuasca, and the slow work of picking who you eat with.
2:28:37ENThe Marshals Came for an Underground City. RFK Jr. Still Wants a President Who Can Say NoInvitado: Robert F. Kennedy Jr · Presenta: Lex FridmanOn Independence Day 2023, Lex Fridman sat with Robert F. Kennedy Jr. for two and a half hours on Cuba, Ukraine, the CIA, pharma, and why the shopping cart still has to go back.
3:15:07ENWikipedia Worked Once Writing Stopped Feeling Like Grad SchoolInvitado: Jimmy Wales · Presenta: Lex FridmanJimmy Wales tells Lex Fridman how Nupedia's seven-stage review died, why Wikipedia still refuses ads and governments, and what large language models should actually do with an encyclopedia.
4:27:46ENHalf a Million Girls in Wells, and We Still Change the ChannelInvitado: Sam Harris · Presenta: Lex FridmanSam Harris tells Lex Fridman why emotional contagion is a bad moral compass, why Trump broke norms more than laws, and why Twitter, COVID, and AGI all look like failures of seriousness.
4:11:06ENThe climate problem is real. The 12-year asteroid story is not.Presenta: Lex FridmanBjørn Lomborg and Andrew Revkin tell Lex Fridman why vulnerability, cheaper tons of carbon, and energy innovation matter more than apocalyptic deadlines.
2:43:51ENTwo Tubes, Millimeters Apart: Jonathan Reisman on the Honest Design of the Human BodyInvitado: Jonathan Reisman · Presenta: Lex FridmanThe emergency physician and author of The Unseen Body walks Lex Fridman from the throat to the Arctic, arguing that anatomy is mostly brilliant, sometimes a near-miss, and always a story written in scars.
1:42:06ENJonathan Haidt: Instagram Is Not 'Generally Positive' for Teen MindsInvitado: Jonathan Haidt · Presenta: Lex FridmanThe NYU social psychologist answers Mark Zuckerberg on adolescent mental health and argues that one business model rewired childhood and then the public square.
2:55:05ENExtinction awareness is the human trait Mason wants to carry to the starsInvitado: Chris Mason · Presenta: Lex FridmanCornell geneticist Chris Mason on why seeing our own end creates a duty to engineer life for other worlds — and what a 500-year plan would actually require.
2:29:08ENStarvation Is a Weapon. Skye Fitzgerald Still Puts the Camera Down.Invitado: Skye Fitzgerald · Presenta: Lex FridmanNearly 811 million people are hungry today, and 45 million stand at the edge of famine across 43 countries — while the food to feed them already exists.
2:49:41ENNazi Science Was Not Anti-Science. It Was Science with a Purity QuestInvitado: Robert Proctor · Presenta: Lex FridmanStanford historian Robert Proctor on how ideology, tobacco, and the taxonomic impulse turn scientists into widget-builders.
2:17:29ENThe knowledge doctors trust is built to sell drugsInvitado: John Abramson · Presenta: Lex FridmanHarvard physician John Abramson tells Lex Fridman how pharmaceutical companies captured medical knowledge, and why American healthcare spends more while delivering less.
2:21:49ENFocused Protection, Not Lockdowns: Jay Bhattacharya on What Public Health Got WrongInvitado: Jay Bhattacharya · Presenta: Lex FridmanThe Stanford physician and co-author of the Great Barrington Declaration tells Lex Fridman why age-stratified risk, seroprevalence data, and the ignored costs of isolation pointed to a different COVID strategy.
1:08:04ENBreakthroughs Run on Speed. Trust Runs on Patience.Invitado: Albert Bourla · Presenta: Lex FridmanPfizer CEO Albert Bourla talks with Lex Fridman about the November 2020 unblinding, a $2.3 billion all-in bet, and why a historic vaccine still divided the public.
4:55:09ENJamie Metzl Puts the Lab-Leak Odds at 85 PercentInvitado: Jamie Metzl · Presenta: Lex FridmanThe genetic-engineering author walks Lex Fridman through the circumstantial case for a Wuhan accident, the cover-up he says is no longer debatable, and why the next pandemic will be decided by transparency, not blame.
1:26:53ENFrancis Collins Cannot Exclude a Lab LeakInvitado: Francis Collins · Presenta: Lex FridmanThe outgoing NIH director talks with Lex Fridman about COVID origins, gain-of-function research, Anthony Fauci, vaccines, and why scientific certainty is the wrong pose.
1:46:47ENA Perfect Rapid Test Would Fail the FDA. Michael Mina Explains Why That Is the PointInvitado: Michael Mina · Presenta: Lex FridmanThe Harvard immunologist tells Lex Fridman that paper-strip antigen tests answer the only public-health question that matters—are you infectious right now—and that one presidential sentence could unlock them.
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