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28:43ENHow leaders make room for calm when plans keep changingInvitado: DJ Patil, Raina Kumra, Hayden Brown, Baratunde Thurston, John Mills, Dara Treseder, William Treseder · Presenta: Bob SafianA double pendulum, wildfire warnings and a family’s “glass balls” offer different ways to navigate uncertainty.
36:45ENGarry Tan on YC Founders, Personal AI Agents and Open MarketsInvitado: Garry Tan · Presenta: Walter IsaacsonIn a June 2026 interview, the Y Combinator CEO discusses founder selection, AI’s effect on work and the risk of concentrated platform power.
11:59ENUse two AI agents to turn a prototype into a front-end specificationDevin Chasanoff · GoogleDevin Chasanoff separates planning from documentation so Gemini can help a user design an app before building it.
17:13ENHow Factory Separates AI Agents from the Compute They Run OnNikhil Harithas · FactoryNikhil Harithas explains a proposed compute lifecycle layer, outbound relay and customer-controlled deployment for enterprise agents.
51:52ENHow GDPx Tests Frontier AI: Inside SemiAnalysis’s New BenchmarkInvitado: Max Kan, Andrew Megalaa · Presenta: Jordan NanosThe team behind GDPx explains task quality, domain selection, grading and the trade-off between public scrutiny and private evaluations.
59:18ENScott Nolan on Rebuilding US Uranium Enrichment and the Cost of Nuclear PowerInvitado: Scott Nolan · Presenta: John CollisonThe General Matter CEO talks with John Collison about fuel supply, a planned Kentucky facility and lessons from SpaceX.
34:48ENZach Lloyd on the Infrastructure Behind a Software FactoryInvitado: Zach Lloyd · Presenta: Shawn Wang (swyx)Warp’s founder explains how teams can define, observe and improve agentic development workflows—and when the additional infrastructure may be excessive.
24:58ENQuantum computing leaders see early uses before large-scale commercial valueMark Bergen, Carmen Palacios-Berraquero, Jan Goetz, Ebba Carbonnier · BloombergQuantum executives discuss hybrid machines, the race to protect encryption and their forecasts for commercial applications.
15:50ENTheo Compares Codex and Claude Subscription Value After Limit ChangesTheoTheo looks at estimated allowances, per-task costs and his own review experiments, while arguing that model quality remains decisive.
29:23ENWhat happens when a tech company’s mission becomes your identityAmy Thomson, Kristi Coulter, Claire Stapleton · BloombergFormer Amazon and Google employees Kristi Coulter and Claire Stapleton describe growth, dissent and the emotional weight of company missions.
15:03ENHow Peter Yang Used an AI Phone Agent to Negotiate His Internet BillAn AI call negotiated a lower price and faster service, but Yang still had to approve the change himself.
48:08ENAndrew Huberman on Building a Sustainable Routine for Focus and HealthDaisy Wolf, Andrew Huberman · a16zThe neuroscientist describes his daily routine, his struggle with social media, and how he protects the hours when he does his best work.
24:22ENThe creator of Tilly Norwood on AI actors and human storytellersParmy Olson, Eline Van der Velden · BloombergEline Van der Velden explains the people behind an AI character, the backlash it drew and her plans for an AI-assisted film.
19:00ENIsomorphic Labs Bets on Simulated Experiments to Design Better DrugsShirin Ghaffary, Max Jaderberg · BloombergMax Jaderberg says AI can test drug ideas in simulations, but proving treatments work still requires laboratory experiments and clinical trials.
1:53:06ENLindsay Owens on Price Experiments, Consumer Data and the Fight for Fair PricesInvitado: Lindsay Owens · Presenta: Theo VonThe consumer advocate explains her investigations into changing prices and data-driven commerce, and what shoppers and lawmakers can do.
16:29ENWhy Retrieval Quality Matters for AI Agents Working with Large Document CollectionsAamir Shakir · MixedbreadMixedbread’s Aamir Shakir critiques a multi-stage retrieval pipeline and presents a customer case and multimodal search demo.
42:30ENInside Figma’s PM OS: Ezra Mechaber on Skills, Bug Bashes and Automated ExperimentsInvitado: Ezra Mechaber · Presenta: Claire VoFigma growth PM Ezra Mechaber shows Claire Vo how a shared repository supports product work, browser testing and a human-reviewed experiment loop.
16:48ENNathan Lambert on How Open Models Can Compete With Frontier LabsNathan Lambert · Allen Institute for AIOpen models are gaining use and closing capability gaps, but their builders need a sustainable economy and advantages beyond price.
1:37:08ENJoscha Bach on Consciousness, Causal Patterns and Machine MindsInvitado: Joscha Bach · Presenta: Tim ScarfeA discussion of a speculative machine-consciousness hypothesis, the limits of behavioral tests and competing accounts of mind.
16:46ENTheo Browne on Claude Ultra, Five-Hour Limits and SDK UsageTheo Browne · Ping LabsA breakdown of the renamed subscription tier, verification and reported differences between interactive and SDK usage.
1:43:15ENJoe Hudson on Decisions, Fear and Living by Your PrinciplesInvitado: Joe Hudson · Presenta: Chris WilliamsonCoach Joe Hudson joins Chris Williamson to explore indecision, emotional avoidance, personal principles and the value of learning through action.
15:51ENAdam Nahari: Six Moves to Turn AI Pilots Into Financial ImpactAdam Nahari · ApolloAn airline crew-scheduling example shows why financial outcomes depend on workflow redesign, adoption and disciplined measurement.
1:01:08ENNebius CTO Danila Shtan on AI Clouds, Inference and Competition with HyperscalersInvitado: Danila Shtan · Presenta: Jacob EffronDanila Shtan tells Jacob Effron how Nebius builds AI infrastructure, where inference remains inefficient and why he expects larger clouds to compete more aggressively.
44:57ENTutor Intelligence CEO Josh Gruenstein on Building Robots for Real WorkInvitado: Josh Gruenstein · Presenta: Martin Casado, Raghu RaghuramJosh Gruenstein joins Martin Casado and Raghu Raghuram to discuss human tutors, robot manufacturing and the economics of factory automation.
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