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19:19ENApprove the Application, Not the AI Model: Building Evaluation Gates for a BankDoneyli De Jesus · Langfuse by ClickHouseDoneyli De Jesus explains how a bank tested an AI agent on its own data, added a calculator and used domain experts to set production gates.
2:43:00ENSam Tallent and Joe Rogan on Writing, Comedy, and Finding PerspectiveGast: Sam Tallent · Moderation: Joe RoganThe comedian and author discusses his novel Brut, the demands of touring and the value of creative work beyond online approval.
31:44ENTheo on Improving Agent-Generated UI With Iterative ReviewsTheoA T3 Code experiment uses multiple model reviewers, screenshots and repeated changes to improve an interface, while exposing the limits of subjective scores.
53:41ENEthan Mollick on Entrepreneurship, AI Agents, and Preserving Human JudgmentGast: Ethan Mollick · Moderation: Marina MogilkoThe Wharton professor explains how to use AI as a managed collaborator while retaining the skills and choices that matter to you.
12:58ENMatthew Berman on Building Personal Software With AIMatthew Berman · Forward FutureA homemade PDF reader leads Berman to argue that coding agents could make customized consumer software more accessible.
16:51ENCristóbal Valenzuela on Interactive Video Models and Runway’s ContinuumCristóbal Valenzuela · RunwayRunway’s co-founder traces next-frame prediction from early generated film to research prototypes for interactive visual interfaces.
19:42ENWhat Drives AI Agent Costs: Cache Hits, Input Tokens and TurnsGeorge Cameron · Artificial AnalysisArtificial Analysis co-founder George Cameron breaks down an agent benchmark and a framework for choosing models by cost and capability.
12:25ENThe Fat Electrician Tells the Story of Sergeant Reckless, the Korean War HorseGast: The Fat Electrician · Moderation: Chris WilliamsonChris Williamson and his guest swap stories about military animals, from Wojtek the bear to a Marine Corps horse.
20:35ENGraph Engineering for Agents: Explicit Procedures, Memory and GovernanceZachary Blumenfeld · Neo4jNeo4j’s Zachary Blumenfeld describes three kinds of graphs and demonstrates a graph-shaped loan-review skill.
1:08:18ENAlex Davis on Concentrated Investing, AI Compute, and Private-Market RiskGast: Alex Davis · Moderation: Alex HeathThe Disruptive investor explains his new fund, his approach to late-stage companies and his concerns about speculative infrastructure and private-market vehicles.
28:43ENHow leaders make room for calm when plans keep changingGast: DJ Patil, Raina Kumra, Hayden Brown, Baratunde Thurston, John Mills, Dara Treseder, William Treseder · Moderation: Bob SafianA double pendulum, wildfire warnings and a family’s “glass balls” offer different ways to navigate uncertainty.
36:45ENGarry Tan on YC Founders, Personal AI Agents and Open MarketsGast: Garry Tan · Moderation: Walter IsaacsonIn a June 2026 interview, the Y Combinator CEO discusses founder selection, AI’s effect on work and the risk of concentrated platform power.
11:59ENUse two AI agents to turn a prototype into a front-end specificationDevin Chasanoff · GoogleDevin Chasanoff separates planning from documentation so Gemini can help a user design an app before building it.
17:13ENHow Factory Separates AI Agents from the Compute They Run OnNikhil Harithas · FactoryNikhil Harithas explains a proposed compute lifecycle layer, outbound relay and customer-controlled deployment for enterprise agents.
51:52ENHow GDPx Tests Frontier AI: Inside SemiAnalysis’s New BenchmarkGast: Max Kan, Andrew Megalaa · Moderation: Jordan NanosThe team behind GDPx explains task quality, domain selection, grading and the trade-off between public scrutiny and private evaluations.
59:18ENScott Nolan on Rebuilding US Uranium Enrichment and the Cost of Nuclear PowerGast: Scott Nolan · Moderation: John CollisonThe General Matter CEO talks with John Collison about fuel supply, a planned Kentucky facility and lessons from SpaceX.
34:48ENZach Lloyd on the Infrastructure Behind a Software FactoryGast: Zach Lloyd · Moderation: Shawn Wang (swyx)Warp’s founder explains how teams can define, observe and improve agentic development workflows—and when the additional infrastructure may be excessive.
24:58ENQuantum computing leaders see early uses before large-scale commercial valueMark Bergen, Carmen Palacios-Berraquero, Jan Goetz, Ebba Carbonnier · BloombergQuantum executives discuss hybrid machines, the race to protect encryption and their forecasts for commercial applications.
15:50ENTheo Compares Codex and Claude Subscription Value After Limit ChangesTheoTheo looks at estimated allowances, per-task costs and his own review experiments, while arguing that model quality remains decisive.
29:23ENWhat happens when a tech company’s mission becomes your identityAmy Thomson, Kristi Coulter, Claire Stapleton · BloombergFormer Amazon and Google employees Kristi Coulter and Claire Stapleton describe growth, dissent and the emotional weight of company missions.
15:03ENHow Peter Yang Used an AI Phone Agent to Negotiate His Internet BillAn AI call negotiated a lower price and faster service, but Yang still had to approve the change himself.
48:08ENAndrew Huberman on Building a Sustainable Routine for Focus and HealthDaisy Wolf, Andrew Huberman · a16zThe neuroscientist describes his daily routine, his struggle with social media, and how he protects the hours when he does his best work.
24:22ENThe creator of Tilly Norwood on AI actors and human storytellersParmy Olson, Eline Van der Velden · BloombergEline Van der Velden explains the people behind an AI character, the backlash it drew and her plans for an AI-assisted film.
19:00ENIsomorphic Labs Bets on Simulated Experiments to Design Better DrugsShirin Ghaffary, Max Jaderberg · BloombergMax Jaderberg says AI can test drug ideas in simulations, but proving treatments work still requires laboratory experiments and clinical trials.
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