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1:45:55ENFrom Static Structures to Moving Molecules: Where AI for Protein Design Stands After AlphaFold 3主持 Nathan LabenzComputational biochemist Amelie Schreiber walks Nathan Labenz through six months of progress in structure prediction, molecular dynamics, peptide and antibody models, and early agent-driven design workflows.
46:21ENForty-Eight Miles, Twelve Thank-Yous: Lex Fridman Takes On the Goggins Challenge主持 Lex FridmanLex Fridman runs four miles every four hours for 48 hours and records a gratitude reflection after each session.
1:17:25EN → 简体中文别迷信流程:设计工作正在围着工程师和智能体重建主持 Lenny RachitskyClaude Cowork 设计负责人 Jenny Wen 解释,经典的调研—线框—迭代为何正在失效,设计师现在做什么,以及她想招什么样的人。
1:47:31EN → 简体中文从狂热梦境到旷野:Drew Houston 讲 Dropbox 的三个时代嘉宾 Drew Houston · 主持 Lenny RachitskyDropbox 联合创始人兼 CEO 回顾病毒式增长、Google Photos 的打击、押注生产力,以及随后的个人与组织重置。
40:42ENDon't Mistake a Month of Hype for the End of Software主持 Sarah Guo, Elad GilSarah Guo and Elad Gil separate the SaaS-apocalypse noise from the real signals: record revenue ramps, collapsing token prices, and the question of when a founder should sell.
34:57ENIt's Six Months In: Misconceptions About AI, Regulation, Context Windows and Incumbents主持 Sarah Guo, Elad GilSarah Guo and Elad Gil answer listener questions on what the market gets wrong about generative AI, from the nuclear-regulation analogy to where startups can still beat incumbents.
2:01:57EN → 简体中文先雇两个你会买单的销售:Jason Lemkin 谈招人、薪酬和产品协同嘉宾 Jason Lemkin · 主持 Lenny RachitskySaaStr 创始人讲清楚何时招第一批销售、招什么样的人、怎么发钱,以及产品和销售怎样共事才不会互相拖垮。
1:37:47EN → 简体中文漏洞能打补丁,模型打不了:为什么 AI 防护栏挡不住攻击嘉宾 Sander Schulhoff · 主持 Lenny Rachitsky对抗鲁棒性研究者 Sander Schulhoff 说明,提示注入和越狱至今无解,防护栏产品给不了企业真正的保护,团队眼前该靠权限和隔离。
2:53:45ENJoscha Bach on Seven Stages of Lucidity, Brutalist LLMs, and Why Life on Earth Isn't Only About Humans嘉宾 Joscha Bach · 主持 Lex FridmanA wide-ranging conversation on how minds are built, what language models are missing, and how an AI-saturated world might change consciousness, identity and risk.
17:40ENFrom AlphaGo Zero to MuZero: How Self-Play Strips Knowledge Out of AI主持 Lex FridmanDeepMind's David Silver explains why removing human knowledge made AlphaZero stronger and more general, and how MuZero extended the idea to worlds with unknown rules.
53:39ENA Libertarian's Case for Regulating AI: Kill Switches, Chip Choke Points and a New Form of Life主持 Nathan LabenzLindy founder Flo Crivello explains why a self-described accelerationist makes an exception for superintelligence, and what he thinks of Biden's executive order.
1:18:22EN → 简体中文船坞、锐利问题和谦逊:两位老产品负责人看 AI 时代的产品经理主持 Lenny RachitskyOji 和 Ezinne Udezue 讲产品管理哪里在变、现在该招什么人,以及把 AI 用得好的公司到底做对了什么。
1:41:44EN → 简体中文别人走直路时你该绕:HubSpot联合创始人谈简单、文化当产品和按长处建公司嘉宾 Dharmesh Shah · 主持 Lenny RachitskyHubSpot联合创始人兼CTO Dharmesh Shah向Lenny讲述,为何十八年零直接下属、如何用「每分钟笑声」练演讲,以及把文化当产品来迭代。
23:57ENChips, Agents and a Reckoning: Sarah Guo and Elad Gil on the 2023 AI Boom主持 Sarah Guo, Elad GilThe hosts answer listener questions on the GPU crunch, how soon enterprises will ship AI products, how to build agents, and what 2024 holds for tech valuations.
1:02:49EN → 简体中文别再当傲慢医生:Andy Raskin 教你推销一场运动,而不是一个产品嘉宾 Andy Raskin · 主持 Lenny Rachitsky战略叙事顾问 Andy Raskin 拆解 Salesforce、Zuora、Gong 背后的五段故事结构,以及怎样把它变成公司的北极星。
44:30ENOpen the Front Door: Emil Michael on Rebuilding U.S. Defense Around Startups, AI and Supply Chains主持 Sarah Guo, Elad GilThe Pentagon's research and engineering chief explains his six technology priorities, the rapid launch of GenAI.mil, and why new entrants and domestic manufacturing are now urgent.
1:10:32EN → 简体中文十亿美元、没有 VC、不到一百人:Surge AI 如何把数据质量做成一门艺术嘉宾 Edwin Chen · 主持 Lenny Rachitsky创始人 Edwin Chen 讲述这家自举的人类数据公司如何做到极高人均产值,为什么他完全不信排行榜,以及强化学习环境为何会成为下一阶段。
1:07:22ENCars That Drive Empty: Emilio Frazzoli on Why Self-Driving Needs Rules, Not Just Data主持 Lex FridmanThe nuTonomy CTO explains why full autonomy and shared fleets are where the value lies, and why the hardest open problem is deciding how vehicles should behave.
1:16:17EN → 简体中文更快,可是为了什么?Nicole Forsgren 谈 AI 时代如何衡量开发者生产力嘉宾 Nicole Forsgren · 主持 Lenny RachitskyDORA 和 SPACE 的提出者解释为什么多数生产力指标会骗人,AI 如何改写心流与信任,以及怎样把开发者体验做成能证明价值的项目。
1:04:21EN → 简体中文引导才是增长最大的杠杆:Airtable 前增长负责人怎么选激活指标嘉宾 Lauryn Isford · 主持 Lenny RachitskyLauryn Isford 谈为何别把一切都做成 A/B 测试、怎样挑难达成的激活指标、反向试用,以及 PLG 漏斗。
1:49:39EN → 简体中文不融资、连赚24年:Jason Fried 如何把小公司做成最赚钱的那种嘉宾 Jason Fried · 主持 Lenny Rachitsky37signals 联合创始人解释,一家约75人、没有投资人的公司如何比更大的对手赚得更多,以及他为什么用两人、六周的节奏做产品。
1:35:39EN → 简体中文每天只选一件高光:Make Time如何对抗忙碌和无限信息流嘉宾 Jake Knapp, John Zeratsky · 主持 Lenny RachitskyJake Knapp和John Zeratsky拆解Make Time的四步框架:选高光、激光专注、养能量、带着好奇心复盘,并简要介绍五天设计冲刺。
1:34:57EN → 简体中文十五个人、四款产品、零行手写代码:Every 怎样用 AI 当一家更大的公司嘉宾 Dan Shipper · 主持 Lenny RachitskyEvery 联合创始人兼 CEO Dan Shipper 讲述十五人团队如何用 Claude Code、AI 运营负责人和复利工程,撑起日报、四款产品和咨询业务。
1:10:19ENThe Robot That Folded the Laundry: Physical Intelligence’s Three Frontiers主持 Jacob EffronKarol Hausman and Danny Driess explain how robot foundation models moved from coded primitives to web-scale pretraining, and why performance is now the hard gate.
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