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1:19:47ENScott Kirby on United’s Fleet Bet, Starlink and Airline Economicsゲスト Scott Kirby · ホスト John Collison, Ben ThompsonUnited Airlines CEO Scott Kirby explains how he thinks about investing through downturns, building technology and running an airline network.
1:07ENGeorge Kurtz on How AI May Change Cyberattacksゲスト George KurtzThe CrowdStrike CEO describes his assessment of evolving threats.
42:06ENDario and Daniela Amodei on Building Anthropic, AI Safety, and Human Meaningゲスト Dario Amodei, Daniela Amodei · ホスト Walter IsaacsonThe Anthropic co-founders discuss the roots of their partnership, the challenge of keeping AI systems honest, and the choices facing a world of more capable models.
29:40ENHow Reddit Proto Connects Design, Live Data and Production Codeゲスト Blair Metcalf · ホスト Claire VoBlair Metcalf demonstrates Reddit’s internal prototyping harness and its design-system mapping for Figma and Cursor.
16:34ENIan Quigley on Testing Scientific Agents in Premeasured Worldsゲスト Ian QuigleyLeash Bio’s Minos environments replay physical measurements so agents can explore medicinal chemistry decisions at scale.
15:33ENFiggie Strategy: Reading Hands, Winning Majorities and Pricing CardsBradley, Mike · Jane StreetJane Street traders Bradley and Mike analyze three games to show how private information, market competition and timing affect card prices.
56:01ENXander Song on Evaluating Agents with Harbor and PhoenixXander Song · Arize AIArize AI engineer Xander Song explains how Harbor runs realistic agent tasks in isolated sandboxes, and how his team uses Phoenix to compare prompt changes, inspect trajectories, and test a SQL tool.
22:33ENWilliam Schor: From Unit Tests to Synthetic Canaries at NetflixWilliam Schor · NetflixHow generated workloads and production-like infrastructure help test a distributed key-value service.
18:55ENJeff Maurone on Citadel Securities’ Market Analytics and TechnologyThe technology COO describes tools for market positioning, credit spreads and client questions, and the research infrastructure behind them.
1:05:44ENMarvin Schwaibold on AI-Powered Design, Interactive Prototypes and Better WebsitesAaron Epstein, Marvin Schwaibold · Y CombinatorShopify’s product design studio lead shows how he uses AI to build and refine interactions, then reviews six websites with Aaron Epstein.
3:34:27ENAI, Mathematics, and the Meaning of a Proofゲスト Steven Brunton, Ankur Moitra, Alex Kontorovich · ホスト Lex FridmanLex Fridman and three mathematicians discuss recent AI-generated research, hard open problems and what human understanding contributes.
19:43ENJack Wotherspoon on Building a Team of Managed AgentsJack Wotherspoon · Google DeepMindGoogle DeepMind’s Jack Wotherspoon introduces Gemini Managed Agents: cloud sandboxes that let teams run coding and research agents with a single API call. He explains how persistent environments, reusable skills, proxy-injected credentials, schedules, and specialized agents fit together.
53:04ENFuad Ali: Building a Feedback Loop to Improve AI AgentsFuad Ali · Arize AIAn Arize workshop connects traces, failure datasets, evaluations, proposed fixes and experiments while keeping human judgment in the loop.
20:55ENJesse Hall: Build Voice Agents for Conversations, Not LeaderboardsJesse Hall · LiveKitLiveKit’s Jesse Hall explains how to evaluate voice agents as real-time systems: understand callers, handle interruptions, keep talking while tools run, and measure the delay people actually hear.
44:58ENMario Draghi on Europe’s Growth, Energy and Security Choicesゲスト Mario Draghi · ホスト Lisa AbramowiczIn an October 2026 conversation with Lisa Abramowicz, the former ECB president discusses fiscal pressures, AI, energy and European integration.
45:34ENHenry Paulson on AI Risk, U.S.–China Relations and Crisis Leadershipゲスト Henry M. Paulson, Jr. · ホスト Jim EspositoThe former Treasury secretary discusses today’s economic risks and lessons from the 2008 financial crisis.
30:37ENTheo’s Three Skills for Reviewing and Shipping with Coding AgentsTheo Browne · Ping LabsHow sol-loop, full-send and full-stop encode review, verification and different levels of merge authority.
18:27ENDaksh Gupta on Building a Better AI Code Review AgentDaksh Gupta · GreptileGreptile co-founder Daksh Gupta explains why a webhook plus a coding agent is not enough for reliable pull-request review—and how targeted prompts, incident data, model inversion, codebase context, browser testing, and task-specific model routing can help.
23:48ENSatya Nadella on Zero Trust for AI and Why Every Company Should Own Its Intelligenceゲスト Satya Nadella · ホスト Harry StebbingsThe Microsoft CEO argues that capable agents need security boundaries even as alignment research remains unsettled, and explains why firms should retain the value created by their own AI use.
30:11ZHAI 如何重构跨境支付:从交易路由、风控到智能体商务ゲスト Leo Li, Apple Gao · ホスト 陈茜硅谷101 从一笔跨境机票付款出发,拆解支付网络的复杂性,以及 Antom 如何把 AI 引入运营、风险判断和智能体交易。
17:56ENHow Bridgewater Keeps Its AI Analyst Inside Permission BoundariesNikhil Benesch, Aaron Linsky · turbopufferAaron Linsky and Nikhil Benesch explain why search over an enterprise vault must honor document permissions without sacrificing recall or speed. Their solution combines vector indexing with native filtering to search hundreds of millions of vectors in roughly 120 milliseconds.
35:19ENSallyAnn DeLucia: How to Write Your First AI EvalSallyAnn DeLucia · Arize AITurn an agent’s real traces into concrete pass/fail criteria, then build an LLM judge you can test, align with people, and run in production.
0:26ENSam Altman on Human Values and Problem-Solving in an AI WorldSam Altman · OpenAIIn a short interview excerpt, Altman considers the enjoyment of solving hard problems and the human role in interpreting results.
20:58ENVinoo Ganesh on Making Financial AI Cite Every NumberVinoo Ganesh · KeplerKepler CEO Vinoo Ganesh explains why financial AI should retrieve and cite figures while deterministic software handles the math. His design makes traceability, retrieval quality, and tenant security part of the answer itself.
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