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38:14ENDiffusion Will Win Inference: Stefano Ermon Bets Parallel Tokens Beat Custom SiliconAnime : Sarah Guo, Elad GilThe Stanford diffusion pioneer tells No Priors why a 50-person lab is training language models that generate many tokens at once — and why that maps to GPUs the way transformers once mapped to training.
1:01:27ENTwo Years and Four Months to a Live Reactor: Valar Atomics Wants Energy Ten Times CheaperAnime : Sarah Guo, Elad GilIsaiah Taylor walks Sarah Guo through Ward 250 in Utah and argues that nuclear is a hardware-iteration problem, not a paper-design one.
30:47ENEmbryos Survive 30 Years Frozen. Until Wants Organs to Stop Racing Private JetsAnime : Sarah Guo, Elad GilLaura Deming on reversible cryopreservation: pause an organ—and someday a patient—so a few months no longer decide who lives long enough for the next therapy.
46:26ZH朱啸虎:三年内看不到泡沫,共识太集中就错开十五度Invité : 朱啸虎 · Anime : 张小珺2025 年底,金沙江创投朱啸虎第三次坐到张小珺对面:AGI 不谈了,入口之争开始了。他不投人形机器人,把支票开给洗船和按摩这类「干活」的公司。
2:36:55ENOne Second of Fuel: David Kirtley on Fusion Power by 2028Invité : David Kirtley · Anime : Lex FridmanThe Helion Energy CEO walks Lex Fridman from 1958 theta pinches to a Microsoft contract that wants first electrons on the grid in 2028.
31:57ENPeak 700 GW, average 300 GW: Base Power is wiring home batteries into a power plantAnime : Sarah Guo, Elad GilZach Dell tells Elad Gil how a $1.3 billion raise, a Texas-only retail business, and a Tesla-and-SpaceX hiring bench are meant to cut the cost of moving an electron.
1:01:49ENTwo Academic Hours a Day, and 96 Percent of Kids Say They Love SchoolAnime : Sarah Guo, Elad GilTrilogy founder Joe Liemandt, now principal of Alpha School, tells No Priors how an AI tutor, a two-hour bargain with fifth graders, and a sports-coach ethos are meant to scale to a billion children.
44:49ENHow OpenEvidence Became the Clinical OS for 40% of U.S. DoctorsAnime : Sarah Guo, Elad GilFounder Daniel Nadler tells No Priors how a free search tool for physicians, not an answer engine for patients, took high-stakes clinical knowledge in 18 months.
1:49:29ENChina Is Not Run by One Person. It Is a Mayor EconomyInvité : Keyu Jin · Anime : Lex FridmanEconomist Keyu Jin on local GDP races, DeepSeek, tariffs, Jack Ma, and why Western collapse forecasts keep missing the country they describe.
40:54ENDiscovery rates collapsed tenfold. KoBold still found a 5% copper depositAnime : Sarah Guo, Elad GilJosh Goldman explains why KoBold Metals treats mineral exploration as an information problem, pairing AI with century-old maps to hunt lithium and copper.
42:42ENEthereum Once Held Two Thousand GPT-3 Clusters of GPUsAnime : Sarah Guo, Elad GilFoundry CEO Jared Quincy Davis on idle H100s, why today's AI cloud is still colocation, and how compound systems move work off giant interconnected clusters.
34:09ENFive Independent Teams Found the Same 10-to-1 Mix That Beats TransformersAnime : Sarah Guo, Elad GilThe authors of S4 and Mamba argue that mostly state-space layers plus a dash of attention is the architecture that actually works—and they are shipping it first as real-time speech.
1:47:08ENKimbal Musk Cooks So People Will Sit DownInvité : Kimbal Musk · Anime : Lex FridmanThe chef, Tesla board member, and author of The Kitchen Cookbook talks with Lex Fridman about apartheid South Africa, a broken neck, Zip2, and why a table beats a nightclub.
36:22ENOne Attacker and a For Loop: Why Email Is Still the Softest Target in an AI Arms RaceAnime : Sarah Guo, Elad GilMaterial Security co-founder Ryan Noon on how 2016 election hacks, Google and Microsoft's email duopoly, and large language models are rewriting both sides of cybersecurity.
3:33:04ENAfrica's Poverty Is Made of Laws, Not of PeopleInvité : Magatte Wade · Anime : Lex FridmanSenegalese entrepreneur Magatte Wade tells Lex Fridman how tariffs, Napoleonic codes, and a Cold War wrong turn keep the world's youngest continent poor.
2:46:26ENApple Was a $5 Billion Company in Debt When Tony Fadell Built the iPodInvité : Tony Fadell · Anime : Lex FridmanLex Fridman talks with Tony Fadell, co-creator of the iPod, iPhone, and Nest Thermostat, about the decisions, fights, and luck behind those products.
1:46:49ENAriel Ekblaw on Self-Assembling Habitats and Why the Real Space Cities Will FloatInvité : Ariel Ekblaw · Anime : Lex FridmanThe MIT Space Exploration Initiative director talks swarm tiles, lunar ants, and why Mars is a research station rather than a backup Earth.
2:59:57ENThe Farmer With a $50 Phone: Sergey Nazarov on Oracles, Trust, and Hybrid Smart ContractsInvité : Sergey Nazarov · Anime : Lex FridmanThe Chainlink co-founder tells Lex Fridman how definitive truth, oracle networks, and cryptographically guaranteed contracts could leapfrog banks, insurers, and marble-column confidence.
2:31:14ENAnonymity Is a Tool: How a Yale Freshman Built a Campus Where Students Could SpeakInvité : Ryan Schiller · Anime : Lex FridmanRyan Schiller tells Lex Fridman how a silenced seminar, a Gallup number, and a Mac bought off YouTube advice became Librex, an anonymous discussion feed for verified college communities.
1:53:41ENSilvio Micali: Money Is a Shared Belief, and a Blockchain Makes It Common KnowledgeInvité : Silvio Micali · Anime : Lex FridmanThe Turing Award cryptographer and Algorand founder tells Lex Fridman why ledgers, lotteries, and one-way functions matter more than mining.
2:16:07ENAsk What Could Go Right: Jason Calacanis on Robinhood, Loyalty, and Two Checks for TeslaInvité : Jason Calacanis · Anime : Lex FridmanThe angel investor and All-In co-host walks Lex Fridman from a Palo Alto dive bar to GameStop, Silicon Valley’s war on friction, and a friendship that kept a car company alive for twelve extra days.
1:39:29ENElectric engines, 20-nanometer cones, and why Natalya Bailey would skip the first thousand on MarsInvité : Natalya Bailey · Anime : Lex FridmanThe Accion Systems founder walks Lex Fridman from ion physics to orbital debris, chip-made thrusters, and the kind of culture that oozes out of a founder.
1:02:14ENThe 28-year wait: Robert Langer on rejection, polymers, and a thousand studentsInvité : Robert Langer · Anime : Lex FridmanThe MIT bioengineer talks with Lex Fridman about drug delivery, tissue engineering, patents, and the long path from a Folkman hypothesis to Avastin.
1:22:51ENDensity, Not Demos: Sertac Karaman on Robots That Fly and DriveInvité : Sertac Karaman · Anime : Lex FridmanThe MIT roboticist and Optimus Ride co-founder on why sharing space with people is harder than building the machine, and why flying at transportation scale is still the tougher problem.
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