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1:18:15ENIf AI Becomes a Being, Steering It Is SlaveryHost Nathan LabenzEmmett Shear and DeepMind's Séb Krier clash over whether alignment means controlling a tool or raising a creature that cares.
3:18:09ENA Thing Is Alive When Its Goals Outrun Its PartsGuest Michael Levin · Host Lex FridmanTufts biologist Michael Levin tells Lex Fridman that intelligence is a spectrum of persuadability, that even a bubble sort hosts unexpected goals, and that the brain is a thin client to a space physics does not own.
1:41:15ENIf Snail Experts Can't Agree, Nobody Gets to Be Sure About AI ConsciousnessHost Nathan LabenzPhilosopher Eric Schwitzgebel argues that every major theory of consciousness has to swallow bizarre bullets, and that confident claims about AI sentience are not epistemically justified.
2:51:58ENSara Walker: Life Is Huge in Time, Not in SpaceGuest Sara Walker · Host Lex FridmanThe astrobiologist tells Lex Fridman why textbook definitions of life fail, how assembly theory measures complexity, and why aliens might disappear into their own causal structure.
3:10:49ENMemory Is Not a Replay: Charan Ranganath on Forgetting, Imagination, and False MemoriesGuest Charan Ranganath · Host Lex FridmanA UC Davis neuroscientist explains why the brain is a cheap prediction machine — and why forgetting is how memory works.
2:09:50ENHe stayed up all night playing Civilization 6 with his mindHost Nathan LabenzDean W. Ball surveys EEG, ultrasound stimulation, and Neuralink with Nathan Labenz, and argues that merging with machines started decades ago.
2:50:44ENThe Pirahã Have No Word for OneGuest Edward Gibson · Host Lex FridmanMIT psycholinguist Ted Gibson tells Lex Fridman why related words sit together, why language is not thought, and why large language models ace form while missing meaning.
1:25:09ENTwo-Headed Worms, Regenerated Legs, and a Sort That Learned to WaitHost Nathan LabenzTufts biologist Michael Levin tells Cognitive Revolution why anatomy is rewritable software, and why he stopped a paper that might have made AI more alive.
2:39:40ENThe Self That Swoops In to Decide Is Not ThereGuest Annaka Harris · Host Lex FridmanAnnaka Harris tells Lex Fridman why conscious will is an illusion, why a pea tendril is a better picture of choice than an inner agent, and why she now treats consciousness as a possible fundamental of physics.
3:00:21ENCut Off a Planarian's Head. The New Brain Still RemembersGuest Michael Levin · Host Lex FridmanMichael Levin argues that DNA only builds hardware, bioelectric networks store body plans, and frog skin cells can become robots that evolution never designed.
2:21:55ENWill Sasso Respects Stand-Up Too Much to Do ItGuest Will Sasso · Host Lex FridmanThe MADtv veteran tells Lex Fridman why he never became a stand-up, why impressions work from the outside in, and why he thinks AI is running the same illusion.
3:43:01ENPut Hydrogen and CO2 in a Tube. Thermodynamics Wants Cells. Nothing Happens.Guest Nick Lane · Host Lex FridmanBiochemist Nick Lane talks Lex Fridman through hydrothermal vents, mitochondria, sex, consciousness, and why bacteria should be common while civilizations are not.
3:11:01ENWhere Do You Go for Wisdom? John Vervaeke on the Meaning CrisisGuest John Vervaeke · Host Lex FridmanA University of Toronto cognitive scientist argues that meaning is a real relationship between self and world, and that modern life has lost the practices that used to repair it.
2:44:16ENIQ at Eleven Predicted Survival at Eighty. Richard Haier on the Finding Psychology Tried to BuryGuest Richard Haier · Host Lex FridmanLex Fridman talks with psychologist Richard Haier about the g factor, The Bell Curve, group differences, and why intelligence research became the most radioactive topic in the field.
3:16:16ENEvolution Never Designed You to See the TruthGuest Donald Hoffman · Host Lex FridmanCognitive scientist Donald Hoffman tells Lex Fridman why natural selection hides reality behind a user interface, and why spacetime itself may be just another icon on the desktop.
3:21:29ENWhen something in the mind breaks, you see what it was forGuest Karl Deisseroth · Host Lex FridmanStanford psychiatrist Karl Deisseroth talks with Lex Fridman about depression, schizophrenia, optogenetics, and why you can treat one symptom without a theory of everything.
1:42:58ENDon't Talk Conclusions. Talk Data.Guest Garry Nolan · Host Lex FridmanA Stanford immunologist sat through the brain scans of people who said they had met UFOs—and treats the rest of the subject the same way.
2:46:31ENThe Official Scientific Worldview Is Incompatible With ConsciousnessGuest Philip Goff · Host Lex FridmanDurham philosopher Philip Goff tells Lex Fridman why panpsychism — the view that consciousness is fundamental and ubiquitous — is the least-bad theory of mind.
1:45:45ENA Blink of Ordered Particles: Brian Greene on Entropy, Meaning, and DeathGuest Brian Greene · Host Lex FridmanThe Columbia physicist talks with Lex Fridman about heat death, consciousness, string theory, the Big Bang, aliens, Mars, and the kind of freedom that survives without free will.
2:52:58ENYou Are Not a Great Writer Until You Write the BookGuest Sean Kelly · Host Lex FridmanHarvard philosopher Sean Kelly talks with Lex Fridman about existentialism, nihilism, and how to live when nothing outside us grounds the self.
2:31:57ENJay McClelland on How Thought Emerges From Neural NetworksGuest Jay McClelland · Host Lex FridmanThe Stanford cognitive scientist talks with Lex Fridman about connectionism, backpropagation, David Rumelhart, and why intuition discovers what logic later proves.
3:12:21ENThe Ape's Brain Runs a Dream: Joscha Bach on Consciousness, Freedom, and MeaningGuest Joscha Bach · Host Lex FridmanA long conversation about the self as a control model, the dream world generated by the brain, free will, language models, evil, love, and how to live without a fixed self.
2:31:30ENThe Brain Is the Last Unengineered System in SocietyGuest Bryan Johnson · Host Lex FridmanBryan Johnson demos Kernel Flow on Lex Fridman, then argues that cognition is society's largest unmeasured input and that numbers, not vibes, should run mental health, diet, and the next wave of brain interfaces.
3:17:20ENThe illusion of free will is itself an illusionGuest Sam Harris · Host Lex FridmanSam Harris talks with Lex Fridman about consciousness, psychedelics, AI, UFOs, jiu-jitsu, and why meaning appears only when attention stops looking elsewhere.
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