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18:39ENHow Ramp tests a bookkeeping agent before and after launchRyan Stevens · RampRyan Stevens explains synthetic businesses, all-or-nothing scoring, skill ablation and a two-period test for agent memory.
16:09ENHow Range’s financial planners built their own AI workflowsMatt Ragone · RangeMatt Ragone’s team used real cases and existing advice standards to build skills, while keeping a certified planner’s review before client delivery.
20:28ENWhy AI coding gains depend on more than faster code generationMartin Harrysson, Prakhar Dixit · McKinseyMcKinsey speakers describe smaller teams, shorter loops, curated context and quality checks observed among enterprise clients.
1:21:42ENWhat AI biology can do now, from cancer data to DNA designAlfredo Gonzalez, Yusuf Roohani, Garyk Brixi, Divya NoriFour researchers explain patient-specific cancer analysis, virtual cells and genome models, separating early experiments from proposed clinical applications.
31:22ENNouha Dziri on Making Coding-Agent Teams More Cost-EfficientNouha Dziri · CohereExperiments on ProgramBench and Commit0 show why the task bottleneck, lead model and coordination design matter more than simply adding agents.
20:08ENMETR Finds Faster AI Research at Anthropic, With Major UncertaintyMatthew Berman · Forward FutureMatthew Berman examines an independent assessment of AI-assisted R&D and the limits on its access to evidence.
19:34ENHow Cloud Agents Help Review Changes to a Security MasterAmol Kapoor, Clifford Ressel · Nori AgenticAmol Kapoor and Clifford Ressel explain why private-asset data is difficult to reconcile and how an agent assists human reviewers.
57:17ENScott Wilson on WashU’s Endowment, Concentration and Co-InvestingGuest Scott Wilson · Host Harry StebbingsWashU’s CIO explains its manager relationships, direct investments, liquidity constraints and views on private-market valuations.
13:27ENA Financial Agent Must Show How It Reached Its DecisionAnirudh Veeraragavan · FieldguideAnirudh Veeraragavan uses a bank reconciliation to show how to make an agent’s work reviewable.
18:09ENOwen Anderson Discusses His ASU Training LawsuitShabbos Kestenbaum, Owen Anderson · PragerUThe professor describes his challenge to diversity training and a separate dispute over his courses; ASU disputes his discrimination allegations.
17:35ENAgent Infrastructure Needs Persistent State and Elastic ComputeAkshat Bubna · ModalModal CTO Akshat Bubna explains how sandboxes, shared storage and network controls support agents at scale.
1:26:17ENAI Forecasts, GPU Markets and the Question of What to BuildGuest Brian Zhou, Mike San Miguel, Bryan Bischof · Host Nathan Labenz, Prakash NarayananNathan Labenz and Prakash Narayanan examine AI acceleration through election forecasting, compute trading and venture research.
1:50:32ENBuild a Financial Workflow With Skills, Data and CodexStefano Fabbri, Oliver Steffmann · OpenAIOpenAI’s Stefano Fabbri and Oliver Steffmann show how a wealth-advice workflow can be extended with internal tools.
18:28ENVinoo Ganesh on Building AI Answers from Verifiable FactsVinoo Ganesh · KeplerKepler’s co-founder describes pointer-based retrieval, deterministic calculations and access controls for financial AI.
44:15ENAmjad Masad and Paul Graham on Replit’s Path to AI CodingPaul Graham, Amjad Masad · Y CombinatorThe Replit co-founder traces agentic coding from user observations and cloud infrastructure to his vision for enterprise work.
1:42:28ENJamin Ball on Anthropic's S-1, Compute Economics and the Frontier Model RaceGuest Jamin Ball · Host swyxAn investor examines Anthropic's filing, from cash flow and convertible notes to the financing and competitive pressures facing frontier AI labs.
33:40ENDennis Prager Responds to the 2026 Midterm ElectionsDennis Prager · PragerUPrager and a host discuss the election result, the administration’s record, Iran and immigration enforcement from a conservative perspective.
1:33:03ENThe All-In Hosts Debate the Midterms and the AI Infrastructure BacklashHost Jason Calacanis, Chamath Palihapitiya, David Sacks, David FriedbergThe panel disagrees over the election’s causes, the future of data centers and who will control AI capacity.
1:22:19ENMichael Feldstein on Cleaner Indoor Air and the Limits of Air FiltersGuest Michael Feldstein · Host Chris WilliamsonThe Jaspr founder connects wildfire restoration to home air quality, ventilation and filtration.
1:04:02ENLance Martin: Audit Prompts, Build Better Evals and Optimize Agent CostLance Martin · AnthropicAn Anthropic engineer explains prompt caching, evaluation design, hill climbing and the architecture of reliable long-running agents.
23:05ZH → EnglishRyo Lu: When We Can Make Anything, Do We Know What We Want?Ryo LuFrom an AI-generated journal to a jazz ensemble, Ryo Lu explores judgment, life and collaboration alongside powerful tools.
48:39ENJohn Somorjai on Salesforce’s Acquisition Strategy in the AI EraAlex Immerman, John Somorjai · a16zSalesforce’s acquisition leader explains build-versus-buy decisions, AI pricing, Slack and the diligence issues that can stop a deal.
10:18ENMidterm Results, Data Centers and Manufacturing: The Wrap UpPragerU reviews election results, local data-center concerns, manufacturing indicators and a toddler snack recall.
49:37ENRamtin Naimi on AI Venture Capital’s Growing Funding CrunchGuest Ramtin Naimi · Host Patrick O'ShaughnessyThe Abstract Ventures founder explains faster financing rounds, capital-hungry AI labs and his search for overlooked founders.
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