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50:51ENFred Graver on Using AI as a Writers’ Room, Not a GhostwriterGuest Fred Graver · Host Dan Shipper, Natalia QuinteroThe writer and producer explains how he develops ideas and uses AI feedback.
24:42ENDwarkesh Patel on Robert Caro’s Lessons About Political PowerThe stories of Robert Moses and Lyndon Johnson show how institutions, leverage and alliances can turn formal authority into lasting power.
52:45ENSam Altman and John Collison on AI safety, compute and agent teamsGuest Sam Altman · Host John CollisonAltman discusses security, AI-assisted mathematics, infrastructure costs and personal agents, while Collison probes the limits of containment and the economics of compute.
2:58:50ENColum Tyrrell and Joe Rogan on Comedy, Ireland and the OutdoorsGuest Colum Tyrrell · Host Joe RoganThe comedians discuss Irish comedy, the pull of nature, media and the long process of developing a stand-up bit.
49:17ENHow New Factories and Supply Chains Could Build the Next SpaceXElena Burger, Erin Price-Wright, Connor Love · a16zErin Price-Wright and Connor Love explain how defense demand, private capital and AI tools could reshape American manufacturing.
53:48ENMustafa Suleyman on AI Consciousness, Containment, and Human ControlGuest Mustafa Suleyman · Host Walter IsaacsonIn a conversation with Walter Isaacson, Microsoft AI’s CEO explains his disagreement over model welfare and the safeguards he believes increasingly capable systems need.
14:50ENCole Gannaway on code review, cross-repository risk and AI software factoriesCole Gannaway · QodoA one-line rename can pass local checks while affecting distant clients. Qodo’s Cole Gannaway explains how review context, shared rules and independent agents can expose those risks.
55:39ENWill Ahmed on WHOOP’s Subscription Model, Health Data and Wearable StrategyGuest Will Ahmed · Host Jason CalacanisThe WHOOP CEO discusses the company’s business model, physiological data, AI features and its account of interactions with the FDA.
19:20ZH → EnglishMichael Hsu: How Robots Can Understand the Physical World Through Touch, Data and ActionThe PaXini founder explains how tactile sensing, data factories and dexterous hands can support physical AI.
11:47ENRevolut’s David Abitbol on self-hosting AI coding models at scaleDavid Abitbol · RevolutAbitbol shares engineering delivery trends, GPU-serving costs and latency tuning, then describes controls for operating the tools in a regulated bank.
16:34ENTariq Shaukat on Building Confidence in AI-Generated CodeTariq Shaukat · SonarSonar’s CEO draws on manufacturing quality practices to propose a way to govern and verify software produced with coding agents.
38:06ENServal’s Jake Stauch on coding agents for enterprise ITGuest Jake Stauch · Host Sarah Guo, Elad GilStauch explains why Serval is challenging ServiceNow, how it approaches permissions and approvals, and why background agents remain difficult to deploy safely.
2:28:13ENRob Kurzban on Emotions Through an Evolutionary LensGuest Rob Kurzban · Host Chris WilliamsonThe psychologist discusses how feelings may measure circumstances and motivate behavior, and where evolutionary explanations remain uncertain.
55:42ENJack Altman and Ev Randle on AI markets, security and the physical worldHost Jack Altman, Ev RandleThe Benchmark partners examine reported AI-lab economics, debate open and closed models, and discuss why security, biology and robotics may shape the next phase.
1:00:41ENChase Lochmiller on Building Crusoe and Scaling an AI Infrastructure CompanyChase Lochmiller · CrusoeThe Crusoe CEO explains an energy-first infrastructure strategy, the decision to sell its Bitcoin business, and what it takes to lead a fast-growing company.
1:00:17ENHarry Stebbings, Jason Lemkin and Rory O’Driscoll on AI financing and venture betsGuest Jason Lemkin, Rory O’Driscoll · Host Harry StebbingsThe investors debate AI lab economics, spending on infrastructure, open-model risks and how to evaluate fast-moving private investments.
1:16:38ENSupabase for Agents: Compute, Postgres and Developer WorkflowsGuest Paul Copplestone, Ant Wilson · Host swyxPaul Copplestone and Ant Wilson discuss infrastructure and the company’s growth.
21:47ENPatrick Smyth on Open-Source Supply Chain Security in the AI EraPatrick Smyth · ChainguardChainguard’s Patrick Smyth discusses faster exploitation, malware in dependencies, zero-days and the expanding attack surface around developer workflows.
1:49:40ENA Strategy for Preserving Options on the Path to Advanced AIGuest Joel Predd, Ben Boudreaux, Matt Chessen · Host Nathan LabenzRAND researchers discuss uncertainty, security architecture and human agency with Nathan Labenz.
39:12ENCate Huston: How Rigour Supports AI-Assisted Development VelocityCate Huston · TwillA two-person team’s experience with release gates, automated checks, prioritization and the cost of shipping faster.
1:24:20ENTobi Lütke on AI Agents, Entrepreneurship and Shopify’s FutureGuest Tobi Lütke · Host Alex HeathShopify’s CEO talks with Alex Heath about agent-led shopping, company culture, monetization and the AI systems he runs at home.
44:26ENStark’s Uwe Horstmann and Johannes Schaback on European defense manufacturingUwe Horstmann, Johannes Schaback, Pat Grady, Luciana Lixandru · StarkThe founders discuss field feedback, procurement reform, manufacturing scale and the safeguards they say govern their autonomous systems.
1:41:17ENTitus Winters on Software Engineering, Teams and CS EducationGuest Titus Winters · Host Gergely OroszA conversation on Google-scale refactoring, testing, AI and how engineers learn.
35:10ENFour Personal AI Agents on Nine Tasks: A User’s TestHost Claire VoClaire Vo compares work and family workflows while acknowledging uneven access and subjective scoring.
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