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1:10:29ENHow Anthropic Used Claude to Improve App PerformanceTheo Browne · Ping LabsTheo Browne examines a two-week performance sprint, its measurement tools, human review and the tradeoffs behind faster interfaces.
1:11:14ENVenky Ganesan on AI Venture Investing, Ownership and the Cost of Missing OutGuest Venky Ganesan · Host Harry StebbingsMenlo Ventures' partner discusses seed bets, concentrated follow-ons, market cycles, investor liquidity and the discipline needed when AI valuations accelerate.
0:26ENA DeepSeek V4.1 Flash Portrait Painted Through a Browser ToolMatthew Berman · Forward FutureMatthew Berman compares a reference headshot with a stylized result made using a Paint-like website.
48:20ENWhy Specialized AI Could Challenge the All-Purpose ModelGuest Alex Atallah, Amjad Masad · Host Erik TorenbergOpenRouter and Replit leaders discuss model choice, agent coordination and safety.
1:05:01ENChase Lochmiller on AI Data Centers, Energy and GPU EconomicsGuest Chase Lochmiller · Host Harry StebbingsCrusoe’s CEO discusses the constraints on AI infrastructure, the economics of GPU capacity and his company’s approach to energy and managed inference.
1:30:54ENHumanoids Outran Usain Bolt. DeepMind Still Scores Robotics as GPT-2Host Nathan LabenzGoogle DeepMind's Gemini Robotics lead on why sprinting is easy, frying an egg is hard, and one brain should drive any body.
1:11ENChamath Palihapitiya on Three AI Governance PracticesA short proposal for tracing AI activity, mapping policies to risk and keeping audit evidence.
1:20:35ENBeyond GPUs: Optical, Neuromorphic and Biological ComputingFrançois Chaubard, Ilker Oguz, Alok Vasudev, Sean Cole · Y CombinatorYC Paper Club explores alternative hardware and the algorithms that might use it.
1:22:29ENAll-In: A White House AI Accord, Economic Data and Midterm PredictionsHost Jason Calacanis, Chamath Palihapitiya, David Sacks, David FriedbergThe hosts discuss voluntary AI governance, cyber defense, economic pressures and differing election forecasts.
51:08ENPersonal AI Agents: Convenience, Oversight and New FrictionGuest Mike Isaac, Erin Griffith, Eli Tan · Host Max ReadHard Fork discusses hands-on use, security and the limits of self-regulation.
13:23ENA Week Coding with Local AI: Memory, Context and SpeedAdrian TwarogAdrian Twarog tests local models on a sponsored mini PC.
35:39ENCompute Scaled a Millionfold. Bandwidth Only 40x. Fractile Wants to Fix That RatioHost Sarah Guo, Elad GilIn the summer of 2022, Walter Goodwin founded Fractile in London to build very fast inference chips for the world's largest models.
59:13ENAI Agents and the Work Behind Enterprise ProcurementGuest Vladimir Keil · Host Seema Amble, Elena BurgerLio’s Vladimir Keil discusses context, negotiation and multi-agent workflows with a16z.
1:06:36ENTheo’s Guide to Running Coding Agents in ParallelTheo Browne · T3Theo explains his approach to subscription usage, agent delegation, review and remote machines, while acknowledging that parts of his setup may violate provider rules.
45:06ENBarrett Lyon on Rebuilding Internet Privacy and InfrastructureGuest Barrett Lyon · Host Joel de la GarzaThe DoxxNet founder discusses mesh networking, tracking, infrastructure operations and his path from DDoS defense to internet art.
38:28ENAI Agent Security and the Challenge of Recursive Self-ImprovementAI Explained examines reported containment failures, model evaluation and the pressure to accelerate AI research.
1:10:10ENHow Voice Agents Learn the Rhythm of ConversationGuest Tsung-Hsien (Shawn) Wen · Host Tim ScarfePolyAI’s Shawn Wen discusses turn-taking, noisy audio and the work of checking AI output.
1:20:28ENAI Valuations, Talent Wars and the Venture Capital Tradeoffs Behind ThemGuest Jack Altman, Jason Lemkin, Rory O’Driscoll · Host Harry StebbingsHarry Stebbings, Jack Altman, Jason Lemkin and Rory O’Driscoll debate large early-stage bets, open-weight models and the changing market for exits.
1:06ENUsing Meta’s Muse for Meal Planning, Refunds and To-Do ListsMatthew Berman · Forward FutureMatthew Berman demonstrates four tasks for Meta’s personal AI agent, with user approval before selected actions.
1:37:23ENSi Sheppard on the Spanish Conquests of the Aztec and Inca EmpiresGuest Si Sheppard · Host Dwarkesh PatelA discussion of alliances, warfare, disease and the enduring consequences of colonial rule.
38:10ENFrom deepfakes to DNA: how SynthID watermarks AIHannah Fry, Pushmeet Kohli, Jeremy Ratcliffe · Google DeepMindHannah Fry sits down with Pushmeet Kohli and Jeremy Ratcliffe to explain SynthID: a mathematical watermark now used on text, images and video, and being extended to protein sequences so DNA synthesis companies can tell AI-designed molecules from nature.
1:28:08ENThe same H100 costs 3x at AWS, and a four-month-old lab is catching genes the top sequencers missedHost Nathan LabenzA Cognitive Revolution weekly briefing on a possible U.S.–China AI hotline, why hyperscalers charge two to three times as much for identical chips, co-writing a novel with frontier models, and an AI loop that re-diagnosed a child a premier prenatal lab had cleared.
52:49ENJake Paul and The Chainsmokers on Turning Audience Attention into BusinessesGuest Jake Paul, Drew Taggart, Alex Pall · Host Chamath Palihapitiya, Jason CalacanisThe creators discuss boxing promotion, music, venture investing and the hard work behind converting fame into durable results.
14:00ENReid Hoffman on AI Infrastructure Risk and OversightHost Aria Finger, Reid HoffmanA discussion of financing guarantees, audits and proposed shutdown mechanisms.
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