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37:00ENThe AlphaChip Team That Laid Out Four TPUs Now Wants Every Company to Be DesignlessAnna Goldie and Azalia Mirhoseini tell Sequoia how an RL floorplanner survived TPU-team anger, learned to draw donut-shaped macros, and became a bet that AI will design chips that then feed AI.
3:06:19ENThey Call Themselves Brothers: First Contact in the AmazonGuest Paul Rosolie · Host Lex FridmanPaul Rosolie tells Lex Fridman about a historic encounter with an uncontacted Amazon clan, a narco war on his river, and the race to buy the last wild corridor.
1:15:19ENAlex Rampell on Venture Scale, Founder Judgment and Durable AI BusinessesGuest Alex Rampell · Host Harry StebbingsThe Andreessen Horowitz investor explains how he weighs ownership, founder motivation and customer retention as venture funds and AI markets grow.
1:36ENWhy Humanoid Robots Can Move Beyond Human LimitsMatthew Berman · Forward FutureMatthew Berman explains why joints that rotate beyond human ranges could help robots work in factories.
1:47ENTurning 2D Images Into 3D Objects With Meta SAM 3DMatthew Berman · Forward FutureMatthew Berman demonstrates object selection, 3D generation and visual effects in a video made in partnership with Meta.
1:54:30ENFrom One in Ten Cancer Cells to One in a MillionHost Nathan LabenzNathan Labenz's solo AMA updates his son's lymphoma treatment, calls Claude Opus 4.5 software AGI, and ranks the live players of early 2026.
38:28ENOscar Hoglund on Value Chains, AI Tools, and Building Epidemic Sound Without Losing Your LifeGuest Oscar Hoglund · Host Marina MogilkoEpidemic Sound’s cofounder joins Marina Mogilko to explain creative contrast, the move from feature to platform, and the discipline behind sustainable company building.
1:16:21ENJensen Huang’s Year-End Case That Token Costs Can Fall a Billion-Fold Without Killing JobsHost Sarah Guo, Elad GilOn No Priors, NVIDIA’s CEO uses radiology, open source, and a $2 trillion R&D budget to argue that 2025’s extremes missed the stack.
1:27:29ENAI Chip Deals, Founder Exits and the Future of WorkGuest Jason Lemkin, Rory O’Driscoll · Host Harry StebbingsHarry Stebbings, Jason Lemkin and Rory O’Driscoll discuss reported Groq and Manus deals, AI compensation, public markets and hiring.
14:34ENLTX-2, NVIDIA Rubin and ChatGPT Health: January 2026 AI NewsMatthew Berman, Jensen Huang · Forward FutureMatthew Berman reviews open video-model tools, NVIDIA’s CES announcements, a health feature, GPU price rumors and reported Anthropic fundraising.
2:01ENA Rumor About OpenAI’s AI Device and Its Possible FormMatthew Berman · Forward FutureMatthew Berman considers a reported pen-like device and speculates about its use alongside a phone.
1:01:38EN13-Hour Coffee and 2x Throughput: Physical Intelligence Crosses the Deployment LineKarol Hausman and Tobi Springenberg tell Sequoia’s Training Data how a general robot brain, plus real-world RL, turned coffee, laundry, and chocolate boxes into jobs that actually run.
5:13ENTesting Meta’s SAM Audio: Isolating Voices and InstrumentsMatthew Berman · Forward FutureMatthew Berman demonstrates prompt-based sound separation and effects in a Meta-partnered video.
1:06:10ENFuse CEO Alan Chang on Revolut, Energy and Building at SpeedGuest Alan Chang · Host Harry StebbingsChang discusses his management approach, energy policy and Fuse’s growth while Harry Stebbings challenges several of his assumptions.
1:55:02ENAn Index Fund on AGI: How MATS Filters the Next 120 AI Safety ResearchersHost Nathan LabenzRyan Kidd, co-executive director of MATS, tells Nathan Labenz why he will not shout a timeline, why every safety technique is also a capabilities technique, and who actually gets hired.
5:55ENTurning Images into 3D Models with Meta SAM 3DMatthew Berman · Forward FutureMatthew Berman demonstrates object extraction, body reconstruction, and a 3D-printing workflow in Meta's SAM Playground.
1:18:40ENWhen AI Becomes the Oil Well: Luke Drago on the Intelligence CurseHost Nathan LabenzThe Workshop Labs co-founder tells the FLI Podcast why a world of non-human production could recreate the resource curse — and how private data, open weights, and moonshot careers might still break it.
1:25:57ENMatt Fitzpatrick on Enterprise AI, Expert Data and Deploying What WorksGuest Matt Fitzpatrick · Host Harry StebbingsInvisible Technologies’ CEO explains his approach to validating AI deployments, sourcing specialists and building customer-specific workflows.
3:52:17ENSome Infinities Are Larger Than OthersHost Lex FridmanJoel David Hamkins walks Lex Fridman from Hilbert's Hotel through Gödel, the continuum hypothesis, and a set-theoretic multiverse where truth is not the same as proof.
1:38ENNVIDIA’s Groq Licensing Deal and the Inference MarketMatthew Berman · Forward FutureMatthew Berman discusses why NVIDIA licensed Groq’s inference technology and hired members of its team.
1:18:15ENIf AI Becomes a Being, Steering It Is SlaveryHost Nathan LabenzEmmett Shear and DeepMind's Séb Krier clash over whether alignment means controlling a tool or raising a creature that cares.
1:41:34ENThey Owned the Camera Partition—and Still Couldn't Crash the HelicopterHost Nathan LabenzKathleen Fisher and Byron Cook tell Nathan Labenz how formal methods turn some software bugs into closed cases, from a DARPA helicopter to AWS policies checked a billion times a second.
1:20:57ENMatt Godbolt: Inside Skylake’s Out-of-Order PipelineMatt GodboltA guided tour of instruction decoding, register renaming, execution and memory ordering, grounded in reverse engineering and careful measurements.
1:12:54ENInvestors’ 2026 Predictions: AI, Software Valuations and EmploymentGuest Jason Lemkin, Rory O’Driscoll · Host Harry StebbingsHarry Stebbings, Jason Lemkin and Rory O’Driscoll review 2025 and debate software stocks, possible IPOs and AI’s labor-market effects.
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