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39:47ENAlphaGenome 2 aims to predict DNA changes in individual cell typesHannah Fry, Žiga Avsec, Adam Gayoso · Google DeepMindDeepMind researchers explain how their model prioritizes genetic variants, what a rare epilepsy case showed, and why predictions still need experiments.
1:43:46ENArthur Brooks on finding meaning beyond distractionGast: Arthur C. Brooks · Moderation: Theo VonBrooks and Theo Von discuss three questions about meaning and routines that leave space for attention and connection.
13:35ENBugzy Malone on replacing rivalry with a different source of driveGast: Bugzy Malone · Moderation: Chris WilliamsonHe and Chris Williamson discuss how threats can motivate preparation—and why inventing enemies can become a crutch.
1:16:31ENBuilding RAG: from document chunks to agents that searchDiyi Yang · Stanford UniversityDiyi Yang explains how indexing, hybrid retrieval and reranking work—and why agents need to check what search returns.
27:44ENPlugin extensions bring interactive tools into ChatGPTCorey, Max Neuber · OpenAIOpenAI describes discovery, sidebar and file entry points, event-driven automation and revised submissions.
18:03ENDmitry Buykin: How to Maintain Code When Agents Outrun ReviewDmitry Buykin · MaerskAt Maersk, weekly pruning, real-task replays and expert feedback help keep an agent-built system understandable.
24:01ENWhen agent work needs loops, subagents and a shared logRaj, Eric · OpenAIOpenAI’s Raj and Eric explain persistence, when to delegate and how they coordinate longer work.
1:02:07ZH灵光 2.0:私人助手要先解决问题,再谈入口与收费Gast: 莫林剑 · Moderation: 陈茜蚂蚁灵光 CTO 莫林剑谈长期目标、超级应用生态、支付安全和主动提醒的边界。
24:24ENWhy electrification needs a stronger grid—and more flexible data centersAaron Rutkoff, Josh Parker, Luke Nelson · BloombergJPMorgan’s Luke Nelson sees grid finance as the bottleneck; Nvidia’s Josh Parker argues flexible data centers can help manage peak demand.
25:15ENWhy renewable projects need finance, grids and long-term buyersAntha Williams, Mark Bowman, Daniel Calderon, Halil Demirdağ · Bloomberg PhilanthropiesA Turkish clean-energy target and an Egyptian wind farm show how developers and public lenders try to bring private money into renewables.
37:29ENAl Gore: Cheaper clean energy can outlast climate rollbacksAkshat Rathi, Al Gore · BloombergGore argues falling clean-energy costs are reshaping markets, but developing countries still need affordable financing.
22:37ENHow GPT Live keeps speaking while an agent worksAlex, Erika · OpenAIOpenAI demonstrates simultaneous voice, background delegation and three ways to return updates.
26:49ENAra Khan: Choose work that improves with AI without being replaced by itAra Khan · ClineCline’s Ara Khan explains an automated evaluation loop and urges engineers to pick problems that benefit from model progress.
21:10ENHow OpenAI turned security findings into verified fixesIan, Kyle · OpenAIOpenAI engineers describe the scan, deduplication and patch verification loop behind Codex Security.
25:17ENPeter Yang splits Claude Code work between Opus and FableHe uses Opus for routine execution and reserves Fable for harder decisions, code audits and family-care coordination.
19:44ENWhat a managed agent harness has to do to keep workingCharlie, Steve · OpenAIOpenAI engineers explain remote sandboxes, long-running state and a human-approved flight rebooking demo.
1:24:54ENZach Reitano: US healthcare must answer to patientsGast: Zach Reitano · Moderation: Patrick O'ShaughnessyRo's founder argues for transparent prices and patient choice, and describes the company's 2022 reset.
1:13:14ENRonnie Chatterji: AI may change work before it changes job countsGast: Ronnie Chatterji · Moderation: Reid Hoffman, Aria FingerOpenAI’s chief economist expects productivity gains, but says attributing them to AI and managing uneven effects will take work.
27:14ENJohn Kerry: Cheaper clean energy needs faster deploymentAaron Rutkoff, John Kerry · BloombergKerry argues clean energy can compete on price, while warning that permitting delays and climate damage add costs.
59:16ENTerence Tao: AI proofs make mathematical understanding more urgentGast: Terence Tao · Moderation: Tyler CowenTao explains why proof abundance may change research, education and the value of human explanation.
26:47ENDan Shipper: AI makes generating ideas cheap; people still choose what mattersModeration: Natalia QuinteroThe Every co-founder uses one customer survey to explain why different perspectives can produce different work from the same model.
27:09ENA six-week coding agent run and what it took to superviseOpenAI engineers describe a CI maintenance agent, long-running context and the cost of keeping it working.
20:48ENSites adds personalized connectors and agent-friendly web appsKatia, John · OpenAIOpenAI demonstrates scheduled updates, per-user plugins and WebMCP in two Sites applications.
29:37ENTheo finds a security use for Gemini 4 Carbon despite coding frustrationsTheoHis tests show fewer false code-analysis claims than Argon, but latency and reliability still push him toward other models.
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