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46:14ENKevin Roose on Reporting AI History and Choosing What to DelegateGast: Kevin Roose · Moderation: Natalia QuinteroThe journalist discusses The AGI Chronicles, interviewing a secretive industry, AI-assisted research and his distinction between weightlifting and forklifting.
18:01ENHow NatWest Tests Customer-Facing AI Agents Before LaunchJonathan Osborne · NatWest GroupJonathan Osborne explains routing controls, human validation, unreliable LLM judges and shadow deployment in a regulated bank.
12:24ENJoe Hudson on Decisions, Boundaries and Learning from ActionGast: Joe Hudson · Moderation: Chris WilliamsonChris Williamson and Joe Hudson discuss how to notice self-compromise, seek advice without surrendering judgment and remain open while acting decisively.
19:48ENWhy Datasite Bought Its Document Parser Instead of Building ItAdit Abraham, Raj Bakhru · ReductoRaj Bakhru and Reducto CEO Adit Abraham discuss the engineering trade-offs behind AI for transaction data rooms.
19:19ENApprove the Application, Not the AI Model: Building Evaluation Gates for a BankDoneyli De Jesus · Langfuse by ClickHouseDoneyli De Jesus explains how a bank tested an AI agent on its own data, added a calculator and used domain experts to set production gates.
2:43:00ENSam Tallent and Joe Rogan on Writing, Comedy, and Finding PerspectiveGast: Sam Tallent · Moderation: Joe RoganThe comedian and author discusses his novel Brut, the demands of touring and the value of creative work beyond online approval.
31:44ENTheo on Improving Agent-Generated UI With Iterative ReviewsTheoA T3 Code experiment uses multiple model reviewers, screenshots and repeated changes to improve an interface, while exposing the limits of subjective scores.
53:41ENEthan Mollick on Entrepreneurship, AI Agents, and Preserving Human JudgmentGast: Ethan Mollick · Moderation: Marina MogilkoThe Wharton professor explains how to use AI as a managed collaborator while retaining the skills and choices that matter to you.
12:58ENMatthew Berman on Building Personal Software With AIMatthew Berman · Forward FutureA homemade PDF reader leads Berman to argue that coding agents could make customized consumer software more accessible.
16:51ENCristóbal Valenzuela on Interactive Video Models and Runway’s ContinuumCristóbal Valenzuela · RunwayRunway’s co-founder traces next-frame prediction from early generated film to research prototypes for interactive visual interfaces.
19:42ENWhat Drives AI Agent Costs: Cache Hits, Input Tokens and TurnsGeorge Cameron · Artificial AnalysisArtificial Analysis co-founder George Cameron breaks down an agent benchmark and a framework for choosing models by cost and capability.
12:25ENThe Fat Electrician Tells the Story of Sergeant Reckless, the Korean War HorseGast: The Fat Electrician · Moderation: Chris WilliamsonChris Williamson and his guest swap stories about military animals, from Wojtek the bear to a Marine Corps horse.
20:35ENGraph Engineering for Agents: Explicit Procedures, Memory and GovernanceZachary Blumenfeld · Neo4jNeo4j’s Zachary Blumenfeld describes three kinds of graphs and demonstrates a graph-shaped loan-review skill.
1:08:18ENAlex Davis on Concentrated Investing, AI Compute, and Private-Market RiskGast: Alex Davis · Moderation: Alex HeathThe Disruptive investor explains his new fund, his approach to late-stage companies and his concerns about speculative infrastructure and private-market vehicles.
36:45ENGarry Tan on YC Founders, Personal AI Agents and Open MarketsGast: Garry Tan · Moderation: Walter IsaacsonIn a June 2026 interview, the Y Combinator CEO discusses founder selection, AI’s effect on work and the risk of concentrated platform power.
17:13ENHow Factory Separates AI Agents from the Compute They Run OnNikhil Harithas · FactoryNikhil Harithas explains a proposed compute lifecycle layer, outbound relay and customer-controlled deployment for enterprise agents.
51:52ENHow GDPx Tests Frontier AI: Inside SemiAnalysis’s New BenchmarkGast: Max Kan, Andrew Megalaa · Moderation: Jordan NanosThe team behind GDPx explains task quality, domain selection, grading and the trade-off between public scrutiny and private evaluations.
59:18ENScott Nolan on Rebuilding US Uranium Enrichment and the Cost of Nuclear PowerGast: Scott Nolan · Moderation: John CollisonThe General Matter CEO talks with John Collison about fuel supply, a planned Kentucky facility and lessons from SpaceX.
34:48ENZach Lloyd on the Infrastructure Behind a Software FactoryGast: Zach Lloyd · Moderation: Shawn Wang (swyx)Warp’s founder explains how teams can define, observe and improve agentic development workflows—and when the additional infrastructure may be excessive.
15:50ENTheo Compares Codex and Claude Subscription Value After Limit ChangesTheoTheo looks at estimated allowances, per-task costs and his own review experiments, while arguing that model quality remains decisive.
48:08ENAndrew Huberman on Building a Sustainable Routine for Focus and HealthDaisy Wolf, Andrew Huberman · a16zThe neuroscientist describes his daily routine, his struggle with social media, and how he protects the hours when he does his best work.
1:53:06ENLindsay Owens on Price Experiments, Consumer Data and the Fight for Fair PricesGast: Lindsay Owens · Moderation: Theo VonThe consumer advocate explains her investigations into changing prices and data-driven commerce, and what shoppers and lawmakers can do.
16:29ENWhy Retrieval Quality Matters for AI Agents Working with Large Document CollectionsAamir Shakir · MixedbreadMixedbread’s Aamir Shakir critiques a multi-stage retrieval pipeline and presents a customer case and multimodal search demo.
42:30ENInside Figma’s PM OS: Ezra Mechaber on Skills, Bug Bashes and Automated ExperimentsGast: Ezra Mechaber · Moderation: Claire VoFigma growth PM Ezra Mechaber shows Claire Vo how a shared repository supports product work, browser testing and a human-reviewed experiment loop.
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