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2:39:45ENThe obesity gene was never the obesity geneGast: Manolis Kellis · Moderation: Lex FridmanManolis Kellis tells Lex Fridman how one nucleotide a million bases from FTO rewrote obesity biology, and why human genetics is now driving the study of disease.
2:23:38ENThe Brain That Never Touches the WorldGast: Lisa Feldman Barrett · Moderation: Lex FridmanNeuroscientist Lisa Feldman Barrett tells Lex Fridman why your skull is a dark box, why emotions are constructed like money, and why empathy is a metabolic bill.
2:10:53ENAll Your DNA Would Reach Jupiter a Hundred Times OverGast: Manolis Kellis · Moderation: Lex FridmanManolis Kellis talks Lex Fridman through the epigenome, Neanderthals, Europa, midlife, and why "are you happy?" is the wrong question.
1:41:24ENA child can lose half a brain. The rest will rewire around the jobGast: David Eagleman · Moderation: Lex FridmanNeuroscientist David Eagleman tells Lex Fridman why the human brain is not hardware running software, but a livewired system that never stops physically reshaping itself.
2:10:06ENYou Might Have to Understand the World to Understand the Letter AGast: Dileep George · Moderation: Lex FridmanDileep George on recursive cortical networks, why a five-year-old can read any new CAPTCHA, and what the Wright brothers actually learned from birds.
2:00:32ENSlow Synapses Grow Fast Learners — Warmth Is the Harder ProblemGast: Matt Botvinick · Moderation: Lex FridmanDeepMind neuroscience director Matt Botvinick tells Lex Fridman how prefrontal cortex, meta-reinforcement learning, and dopamine research meet the human question of what a better life with AI would actually look like.
45:31ENYou Are Your Own Existence Proof: Karl Friston on Free Energy, Life, and Self-AwarenessModeration: Lex FridmanKarl Friston explains how the free energy principle reframes existence, life, planning, and self-awareness as inference problems.
1:29:02ENYou Are Your Own Existence ProofGast: Karl Friston · Moderation: Lex FridmanKarl Friston walks Lex Fridman from brain imaging to the free energy principle, arguing that anything which keeps a boundary looks as if it is doing Bayesian inference.
1:27:57ENThe Brain's Best Computer Has No Inner LifeGast: Roger Penrose · Moderation: Lex FridmanRoger Penrose tells Lex Fridman why HAL raises a moral problem the field will not name, why the cerebellum wrecks the computational theory of mind, and why gravity, Gödel, and an infinite cosmos all hang on the same kind of understanding.
1:12:48ENJohn Hopfield's Physics of Mind: Glitches Become FeaturesGast: John Hopfield · Moderation: Lex FridmanThe Princeton physicist walks Lex Fridman from a wobbly London bridge to Hopfield networks, consciousness-as-story, and why his famous model still does not explain learning.
36:10ENSo You're Saying There's a Chance: Musk on Neuralink, AI, and a Pale Blue DotGast: Elon Musk · Moderation: Lex FridmanLex Fridman and Elon Musk move from consciousness and an AI referee to the engineering of a brain implant, Tesla Autopilot, and Carl Sagan's lonely speck.
1:01:00ENA Hundred Billion Galaxies, and We're Still a Type 0.7 CivilizationGast: Michio Kaku · Moderation: Lex FridmanTheoretical physicist Michio Kaku talks with Lex Fridman about aliens, string theory, digital immortality, and why fusion and Mars are the next civilizational steps.
1:15:58ENHuman Intelligence Is a Ridiculously Narrow SliverGast: Yann Lecun · Moderation: Lex FridmanYann LeCun tells Lex Fridman why giant nets plus gradient descent broke the textbooks, why "AGI" is the wrong word, and why the next leap is a world model learned like a baby.
57:42ENA Brain Organoid Is Not a BrainGast: Paola Arlotta · Moderation: Lex FridmanHarvard developmental biologist Paola Arlotta on how the cerebral cortex is built, why timing and mechanical force are part of the code, and why a dish of stem cells is only a window onto that process.
2:09:42ENThe Brain Does Not Classify Images. It Navigates Maps.Gast: Jeff Hawkins · Moderation: Lex FridmanJeff Hawkins tells Lex Fridman why the neocortex stores the world as thousands of voting reference frames, and why scaling today's networks will not get us there.
1:20:21ENEinstein Was the Worst of Five Ph.D. StudentsGast: Tomaso Poggio · Moderation: Lex FridmanMIT neuroscientist Tomaso Poggio on why intelligence is science's deepest problem, and what brains still have to teach machines.
42:18ENAn Adult Can Change Last Year's Mind. A Network Still Cannot.Gast: Yoshua Bengio · Moderation: Lex FridmanYoshua Bengio tells Lex Fridman that the missing pieces of deep learning sit in credit assignment, training objectives, and a kind of compositionality borrowed from classical AI — not in ten thousand layers.
57:54ENA 2040 Siri That Passes Every Turing Test Still Wouldn't Be ConsciousGast: Christof Koch · Moderation: Lex FridmanNeuroscientist Christof Koch tells Lex Fridman why intelligence is function, consciousness is being, and a perfect brain simulation has no more inner life than a laptop simulating a black hole.
25:06ENLiving Inside the Brain's Story: Joscha Bach on Simulation, Self and ConsciousnessModeration: Lex FridmanIn a clip from his conversation with Lex Fridman, Joscha Bach argues that consciousness, identity and even God are software-like patterns, and that we exist inside a narrative our brain generates.
11:51ENBuilding a Brain: Paola Arlotta on the Choreography of Human Brain DevelopmentModeration: Lex FridmanA Harvard stem cell biologist walks through how the embryo builds the cerebral cortex, why order and environment matter, and why development continues into our twenties.
1:17:38ENBrains Are Body Regulators: Lisa Feldman Barrett on Why Emotions Are Constructed, Not DetectedGast: Lisa Feldman Barrett · Moderation: Lex FridmanIn a guest talk for MIT's AGI course, neuroscientist Lisa Feldman Barrett explains why faces don't display emotions, why brains exist to run bodies, and what that means for building human-like AI.
15:41ENAbolishing Involuntary Death: Ben Goertzel on Immortality, Pain and the Meaning of LifeModeration: Lex FridmanIn a clip from Lex Fridman's podcast, AI researcher Ben Goertzel argues that death and pain should be optional, and sketches what it would take to fund a serious attack on aging.
1:30:52ENBuilding Minds from Unified Theories: Nate Derbinsky on Cognitive Architectures, Soar, and the Case for ForgettingGast: MIT AGI · Moderation: Lex FridmanA guest lecture in MIT's AGI course on how cognitive architectures try to assemble human-level intelligence, and how studying human memory made the Soar architecture faster and better.
11:26ENThe Cookie Your Brain Bakes: Joscha Bach on Happiness, Cells and the Meaning of GodModeration: Lex FridmanIn a short clip, Joscha Bach moves from why happiness is not the point to the cell as a cosmic probe and a naturalistic reading of God as civilization.









