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1:04:51EN125 million cells took a decade. The next billion takes months진행자 Nathan LabenzMark Zuckerberg and Priscilla Chan on pairing a frontier biology lab with a frontier AI lab so models train on data that was designed for them.
1:18:05ENThe Real Bottleneck in AI Research Is Compute, Not Ideas진행자 Jacob EffronAfter NeurIPS, Ari Morcos and Rob Toews sit down with Jacob Effron to argue about plateauing models, SSI’s secrecy, OpenAI’s cash burn, and a set of spicy 2026 bets.
48:00ENA Two-Second Vote Is Training Models to Be Clickbait진행자 Jacob EffronSurge AI CEO Edwin Chen tells Redpoint why LMArena rewards length and emojis, how one lab's models got worse for a year, and why frontier labs are no longer on the same path.
1:32:38ENPolish Is 1% of Frontier Training Data, So Poland Built Its Own Model진행자 Nathan LabenzMarek Kozlowski of Poland's National Information Processing Institute explains how PLLuM uses language adaptation, organic instructions, and on-prem small models to keep a mid-size country in control of its AI.
1:16:53ENKarpathy Called Today's Models Slop. His Decade Timeline Still Sounds Bullish진행자 Jacob EffronDatology AI's Ari Morcos and Radical Ventures' Rob Toews walk through Karpathy's cold water, OpenAI's dealmaking, and who actually pays for the data-center boom.
1:01:49ENChatGPT's Co-Creator Left to Put Nature in the Reward Loop진행자 Nathan LabenzLiam Fedus and Ekin Dogus Cubuk on why language models still fail at physics, why literature data is too noisy to train on, and why Periodic Labs is aiming at a 200K superconductor.
1:22:07ENEvery payment is a frame in a movie. Stripe’s foundation model took card-testing detection from 59% to 97%진행자 Nathan LabenzEmily Sands, Stripe’s head of data and AI, explains how a domain-specific payments model, shared embeddings, and mixed rules turn a $1.4 trillion network into compounding advantage.
1:55:02ENA hundred experiments a day, and the valley of death in materials진행자 Nathan LabenzRadical AI’s co-founders tell Nathan Labenz how a closed loop of frontier models and a self-driving lab is meant to collapse a forty-year materials cycle into less than a decade.
57:52ENThey Aimed for 1%. The Lab Hit 20%. Chai Discovery Moved Antibody Design Onto the Computer.진행자 Jacob EffronJoshua Meier on three waves of AI drug discovery, why Chai-2 behaves like Photoshop for molecules, and why a 1% hit rate was supposed to be enough to change the industry.
23:39ZH李沐:给文本大模型加入一千万小时语音,开源 Higgs Audio李沐 · Boson AI李沐介绍团队如何在文本大语言模型的训练里加入大量语音数据,做成能听能说的 AudioLLM,并把 Higgs Audio 开源。他讲了架构取舍、token 压缩、数据从哪来,以及怎么在 3090 上跑起来。
1:42:06ENEvery Frontier Lab Is Spending a Billion a Year on Data. Here Is Where It Goes진행자 Nathan LabenzLabelbox CEO Manu Sharma on the $15 billion Scale deal, RL “gyms,” $250,000 trainers, and why post-training now eats the budget that used to belong to pre-training.
44:21ENMercor's CEO: Knowledge Work's Next Job Is Writing Evals진행자 Jacob EffronBrendan Foody tells Redpoint how Mercor turned AI hiring and expert data into a $100 million round — and why he thinks a huge slice of white-collar work will become creating tests for models.
1:43:54ENA Year to Grow a Brain Organoid, an Hour to Simulate It진행자 Nathan LabenzStanford postdoc Siyu He tells Nathan Labenz how Squidiff and CORAL move single-cell and spatial experiments into the computer — and where the models still cannot go.
1:40:22ENTwenty-atom crystals taught an AI the physics of a heartbeat진행자 Nathan LabenzOrbital Materials' Jonathan Godwin and Tim Duignan tell Nathan Labenz how a neural network trained on tiny crystals simulated a potassium ion channel on a single 2017 GPU.
1:27:33ENA 70B Model Booked Dinner 20% of the Time. MultiOn Took It to 95% in a Day진행자 Nathan LabenzMultiOn CEO Div Garg returns to The Cognitive Revolution to recap 18 months of agent hype, the AgentQ stack, and why 2025 might still be the year of vertical agents.
1:49:41ENA Team of Fifteen Matched Meta’s Post-Training on Meta’s Own Base진행자 Nathan LabenzNathan Lambert walks through Tulu 3: the three-stage recipe, the 1 percent versus 14 percent lesson, and why open post-training now lives or dies on data and evals.
56:10ENDeepL Beat Google at Translation by Refusing to Be a General Model진행자 Jacob EffronOnly 18 percent of the world speaks English—and a Cologne startup turned that fact into a $2 billion language-AI company.
1:13:23ENAn AI Found a GABA-Cancer Link. The Next Step Is Talking to the Cells.진행자 Nathan LabenzMichael Levin and Leo Pio Lopez on a multilayer embedding that predicted melanoma, a cancer with no mutations, and why biology's real interface is cognitive.
1:16:11ENScooping Food Into Boxes Is 70 Percent of Plant Labor진행자 Nathan LabenzChef Robotics CEO Rajat Bhageria on 20 million plated meals, a foundation model for food, and why the kitchen may leave the house.
1:01:39ENGPT-5 Wants 100 Trillion Tokens. Does Earth Have Enough?진행자 Nathan LabenzTraining GPT-3 took about a trillion tokens; GPT-4 took about ten trillion. The next jump is a data question as much as a compute one.
1:21:50ENA 16K Context Window Holds About 350 Rows. That's Why Tables Need an Agent.진행자 Nathan LabenzGretel AI founder Alex Watson tells Nathan Labenz why most company data is still a spreadsheet, why GPT-4 is the wrong tool for generating it, and how differential privacy lets a model learn a disease without learning a patient.
1:32:40ENThe Historian Who Taught GPT-3.5 to Beat GPT-4진행자 Nathan LabenzMark Humphries on a kilometer of unread paper, fur-trade jargon that embeddings cannot see, and why cheap processing will force history to be rewritten.
2:15:11ENTwenty Gibberish Tokens Jailbroke ChatGPT and Bard진행자 Nathan LabenzCarnegie Mellon’s Zico Kolter, Andy Zou, and Asher Trockman walk through a universal jailbreak that transfers from open models to commercial APIs, and a training-free way to steal some of pretraining’s benefit.
59:28ENFrom $500,000 to $50,000: MosaicML Made Training Your Own Model a Priced Product진행자 Nathan LabenzJonathan Frankle and Abhi Venigalla explain who is training custom LLMs, why extraction beats chat, and how ALiBi stretches a 65k context window.
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