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14:41ENTalking for 20 Minutes: How the Alexa Prize Turns Real Customers into a Testbed for Conversational AIゲスト Rohit Prasad · ホスト Lex FridmanRohit Prasad, head scientist of Amazon Alexa, explains the Alexa Prize grand challenge, how it is judged and why true conversation still needs reasoning.
50:03ENCopilot Is a Copilot, Not a Pilot: Inbal Shani on the Future of AI in Software Developmentホスト Lenny RachitskyGitHub's chief product officer explains what AI changes for developers, what it does not replace, and how teams should adopt it.
1:22:31ENPower Is a Tool: Stanford's Jeffrey Pfeffer on the Seven Rules of Getting Aheadゲスト Jeffrey Pfeffer · ホスト Lenny RachitskyStanford organizational behavior professor Jeffrey Pfeffer walks Lenny Rachitsky through the seven rules of power, the homework that makes them stick, and the price power exacts.
1:45:55ENFrom Static Structures to Moving Molecules: Where AI for Protein Design Stands After AlphaFold 3ホスト Nathan LabenzComputational biochemist Amelie Schreiber walks Nathan Labenz through six months of progress in structure prediction, molecular dynamics, peptide and antibody models, and early agent-driven design workflows.
46:21ENForty-Eight Miles, Twelve Thank-Yous: Lex Fridman Takes On the Goggins Challengeホスト Lex FridmanLex Fridman runs four miles every four hours for 48 hours and records a gratitude reflection after each session.
1:17:25ENDon't Trust the Process: How Design Work Is Being Rebuilt Around Engineers and Agentsホスト Lenny RachitskyClaude Cowork design lead Jenny Wen explains why the classic discovery-to-mock workflow is fading, what designers do instead, and who she wants to hire.
1:47:31ENFrom Fever Dream to Wilderness: Drew Houston on Dropbox's Three Erasゲスト Drew Houston · ホスト Lenny RachitskyDropbox's co-founder and CEO gives a candid account of explosive growth, the Google Photos shock, a painful pivot to productivity, and the personal and organizational reset that followed.
40:42ENDon't Mistake a Month of Hype for the End of Softwareホスト Sarah Guo, Elad GilSarah Guo and Elad Gil separate the SaaS-apocalypse noise from the real signals: record revenue ramps, collapsing token prices, and the question of when a founder should sell.
34:57ENIt's Six Months In: Misconceptions About AI, Regulation, Context Windows and Incumbentsホスト Sarah Guo, Elad GilSarah Guo and Elad Gil answer listener questions on what the market gets wrong about generative AI, from the nuclear-regulation analogy to where startups can still beat incumbents.
2:01:57ENBuild the Sales Team Like a Founder: Jason Lemkin on Hiring, Comp and Keeping Product Closeゲスト Jason Lemkin · ホスト Lenny RachitskySaaStr founder Jason Lemkin walks through when to hire your first reps, who to hire, how to pay them, how product and sales should work together, and why customer-hostile tactics don't compound.
1:37:47ENYou Can Patch a Bug, but You Can't Patch a Brain: Why AI Guardrails Failゲスト Sander Schulhoff · ホスト Lenny RachitskyAdversarial-robustness researcher Sander Schulhoff explains why prompt injection and jailbreaks remain unsolved, why guardrail products don't deliver, and what teams can do instead.
2:53:45ENJoscha Bach on Seven Stages of Lucidity, Brutalist LLMs, and Why Life on Earth Isn't Only About Humansゲスト Joscha Bach · ホスト Lex FridmanA wide-ranging conversation on how minds are built, what language models are missing, and how an AI-saturated world might change consciousness, identity and risk.
17:40ENFrom AlphaGo Zero to MuZero: How Self-Play Strips Knowledge Out of AIホスト Lex FridmanDeepMind's David Silver explains why removing human knowledge made AlphaZero stronger and more general, and how MuZero extended the idea to worlds with unknown rules.
53:39ENA Libertarian's Case for Regulating AI: Kill Switches, Chip Choke Points and a New Form of Lifeホスト Nathan LabenzLindy founder Flo Crivello explains why a self-described accelerationist makes an exception for superintelligence, and what he thinks of Biden's executive order.
1:18:22ENShipyards, Sharp Problems and Humility: Two Veteran Product Leaders on the PM Role in the AI Eraホスト Lenny RachitskyOji and Ezinne Udezue explain how product management is changing, which skills matter now, and what the companies winning with AI do differently.
1:41:44ENZig When Others Zag: HubSpot Co-founder Dharmesh Shah on Simplicity, Culture as a Product and Building a Company Around Your Strengthsゲスト Dharmesh Shah · ホスト Lenny RachitskyThe HubSpot co-founder and CTO explains why he has never had a direct report, how he measures laughs per minute, and the first-principles habits behind HubSpot's contrarian choices.
23:57ENChips, Agents and a Reckoning: Sarah Guo and Elad Gil on the 2023 AI Boomホスト Sarah Guo, Elad GilThe hosts answer listener questions on the GPU crunch, how soon enterprises will ship AI products, how to build agents, and what 2024 holds for tech valuations.
1:02:49ENStop Being the Arrogant Doctor: Andy Raskin on Pitching a Movement, Not a Productゲスト Andy Raskin · ホスト Lenny RachitskyStrategic narrative consultant Andy Raskin explains the five-part story structure behind pitches at Salesforce, Zuora and Gong, and how to make it your company's north star.
44:30ENOpen the Front Door: Emil Michael on Rebuilding U.S. Defense Around Startups, AI and Supply Chainsホスト Sarah Guo, Elad GilThe Pentagon's research and engineering chief explains his six technology priorities, the rapid launch of GenAI.mil, and why new entrants and domestic manufacturing are now urgent.
1:10:32ENA Billion Dollars, No VC, Under 100 People: Surge AI's Edwin Chen on Data Quality and Where AI Is Headingゲスト Edwin Chen · ホスト Lenny RachitskySurge AI's founder explains how a bootstrapped team built the leading human-data company, why he distrusts benchmarks, and how reinforcement learning environments are the next frontier.
1:07:22ENCars That Drive Empty: Emilio Frazzoli on Why Self-Driving Needs Rules, Not Just Dataホスト Lex FridmanThe nuTonomy CTO explains why full autonomy and shared fleets are where the value lies, and why the hardest open problem is deciding how vehicles should behave.
1:16:17ENFaster, But for What? Nicole Forsgren on Measuring Developer Productivity in the AI Eraゲスト Nicole Forsgren · ホスト Lenny RachitskyThe creator of DORA and SPACE explains why most productivity metrics mislead, how AI changes flow and trust, and how to build a developer experience program that proves its value.
1:04:21ENOnboarding Is Growth's Biggest Lever: Lessons from Airtable's Former Head of Growthゲスト Lauryn Isford · ホスト Lenny RachitskyLauryn Isford on rethinking experimentation, choosing a hard-to-reach activation metric, reverse trials, and the PLG funnel.
1:49:39ENNo Investors, 24 Profitable Years: Jason Fried on Staying Small, Trusting Your Gut and Making Money Firstゲスト Jason Fried · ホスト Lenny RachitskyThe 37signals co-founder explains how a 75-person, investor-free company has out-earned far larger rivals, and why he builds products in two-person, six-week cycles.
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