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3Blue1Brown· 16 oct. 2026Grant Sanderson: There's never been a better time to go into mathGrant Sanderson, Constantin Kogler · 3Blue1BrownStudents fear AI has solved mathematics. Grant Sanderson argues the opposite: even if machines prove theorems better than we do, the institution of math stays valuable—and this is a rare moment when newcomers can reshape it.
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No Priors: AI, Machine Learning, Tech, & Startups· 15 oct. 2026Podcast · 2 voixThe Defenders' Window: Greg Brockman on AI-Generated Knowledge, Drug Discovery, and the New Physics of CybersecurityAnime : Sarah Guo, Elad GilOpenAI's president explains why solving open math problems is a proof point for science, how proactive agents change product form, and why security spending must exceed software spending.
29:26ENNo Priors: AI, Machine Learning, Tech, & Startups· 3 avr. 2026Podcast · 2 voixChatGPT Almost Became a Meeting Bot. Its Co-Creator Is Now Rearranging AtomsAnime : Sarah Guo, Elad GilLiam Fedus tells No Priors how Periodic Labs is connecting language models to experiments so materials science can run in a closed loop.
48:14ENNo Priors: AI, Machine Learning, Tech, & Startups· 13 nov. 2025Podcast · 2 voixA New Drug Burns $2 Billion and 10 Years. Benchling's CEO Wants AI to Cut That to ThreeAnime : Sarah Guo, Elad GilMost medicines fail in years seven to ten, after hundreds of millions have already gone into the clinic—and Sajith Wickramasekara thinks sending things to space may already be easier.
13:30EN3Blue1Brown· 17 août 2025How AlphaGeometry Combines Logical Proof with Creative ConstructionAleph0Aleph0 explains how a symbolic geometry solver gets surprisingly far without AI, and how a language model supplies the auxiliary constructions that take it to Olympiad level.
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Lex Fridman· 23 juil. 2025Podcast · 2 voixNature Has Structure: Demis Hassabis on Learnable Reality and AGIInvité : Demis Hassabis · Anime : Lex FridmanThe Google DeepMind CEO argues that evolution-shaped systems can be modeled by classical learning, and that interactive world models sit on the path to AGI.
49:27ENNo Priors: AI, Machine Learning, Tech, & Startups· 3 juil. 2025Podcast · 2 voixFrom 0.1% to 20%: Chai-2 Turns Antibody Design Into Prompt EngineeringAnime : Sarah Guo, Elad GilChai Discovery co-founders Joshua Meier and Jack Dent tell Sarah Guo how a generative model now designs antibodies that bind on the first 24-well plate.
42:09ENNo Priors: AI, Machine Learning, Tech, & Startups· 26 juin 2025Podcast · 2 voixAlphaEvolve found algorithms humans missed for 50 years — then sped up Gemini 23%Anime : Sarah Guo, Elad GilGoogle DeepMind’s Pushmeet Kohli and Matej Balog tell No Priors how an evolutionary coding agent searches algorithm space the way AlphaGo searched Go.
3:14:34ENLex Fridman· 14 juin 2025Podcast · 2 voixIf ten things make a problem hard, Terence Tao turns nine of them offInvité : Terence Tao · Anime : Lex FridmanThe Fields Medalist walks Lex Fridman from the Kakeya needle and Navier-Stokes through Lean, Perelman, and why today's AI still cannot smell a dead-end proof.
40:54ENNo Priors: AI, Machine Learning, Tech, & Startups· 17 avr. 2025Podcast · 2 voixDiscovery rates collapsed tenfold. KoBold still found a 5% copper depositAnime : Sarah Guo, Elad GilJosh Goldman explains why KoBold Metals treats mineral exploration as an information problem, pairing AI with century-old maps to hunt lithium and copper.
40:33ENNo Priors: AI, Machine Learning, Tech, & Startups· 27 févr. 2025Podcast · 2 voixModerna was only company 18. The real product is the company factoryAnime : Sarah Guo, Elad GilNoubar Afeyan tells No Priors how Flagship Pioneering turned starting companies into a profession, underwrites scientific uncertainty, and wants AI to run discovery the way Waymo drives.
57:41ENNo Priors: AI, Machine Learning, Tech, & Startups· 25 févr. 2025Podcast · 2 voixA Hundred Million Cells, Four People, Three Days: Biology's ImageNet MomentAnime : Sarah Guo, Elad GilVevo Therapeutics and the Arc Institute open-sourced Tahoe-100M and a 230-million-cell atlas in the same week — and argued that virtual cells, not just protein folders, are the next language model of biology.
39:22ENNo Priors: AI, Machine Learning, Tech, & Startups· 14 nov. 2024Podcast · 2 voixA Fields Medalist Stuck for Two Hours. AlphaProof Climbed for Three Days.Anime : Sarah Guo, Elad GilThe DeepMind team behind AlphaProof tells Sarah Guo and Elad Gil how an AlphaZero-style agent, a Lean verifier, and test-time reinforcement learning reached IMO silver — and why the missing skill is still theory building.
3:19:21ENLex Fridman· 9 déc. 2023Podcast · 2 voixComplexity without copies is just randomness: Lee Cronin on assembly theoryInvité : Lee Cronin · Anime : Lex FridmanThe Glasgow chemist walks Lex Fridman through his controversial Nature paper, a proposed life meter for other worlds, and the claim that the universe is too big to contain its own future.
37:01ENNo Priors: AI, Machine Learning, Tech, & Startups· 28 sept. 2023Podcast · 2 voixDNA Is Code, but You Compile It with a PipetteAnime : Sarah Guo, Elad GilGinkgo Bioworks CEO Jason Kelly tells No Priors why cells are worth the magic, why biology has no AWS, and why a pandemic should look like cybersecurity.
2:18:25ENLex Fridman· 1 sept. 2023Podcast · 2 voixGrow Everything: Neri Oxman on Giving Nature a VoteInvité : Neri Oxman · Anime : Lex FridmanThe designer-scientist who left MIT to build OXMAN talks silkworm pavilions, bees in space, and why the end of human agency might be the start of nature's.
35:24ENNo Priors: AI, Machine Learning, Tech, & Startups· 24 août 2023Podcast · 2 voixThe Author of Attention Is All You Need Now Compiles mRNA Like BytecodeAnime : Sarah Guo, Elad GilJakob Uszkoreit on why Transformers won, why models spend compute on the wrong things, and why drug discovery has to become generation rather than screening.
2:07:04ENLex Fridman· 28 mai 2023Podcast · 2 voixThe Ribosome Already Solved Digital ManufacturingInvité : Neil Gershenfeld · Anime : Lex FridmanNeil Gershenfeld tells Lex Fridman why Turing separated the head from the tape, how fab labs are the personal-computer moment for making things, and what it would take to grow a civilization from about twenty parts.
46:57ENNo Priors: AI, Machine Learning, Tech, & Startups· 2 mars 2023Podcast · 2 voix95% of Drug Programs Fail. Daphne Koller Is Betting Machine Learning on the First DecisionAnime : Sarah Guo, Elad GilA new medicine still takes more than a decade and well over a billion dollars — and Insitro's founder argues the expensive failures start with the wrong target, indication, or patient.
2:06:25ENLex Fridman· 19 déc. 2022Podcast · 2 voixNathalie Cabrol Wants the Nature of Life, Not Just a Signal from MarsInvité : Nathalie Cabrol · Anime : Lex FridmanThe SETI Institute astrobiologist tells Lex Fridman why crater lakes, panspermia, and a Mandelbrot view of language all point to the same question: what life actually is.
3:43:01ENLex Fridman· 7 sept. 2022Podcast · 2 voixPut Hydrogen and CO2 in a Tube. Thermodynamics Wants Cells. Nothing Happens.Invité : Nick Lane · Anime : Lex FridmanBiochemist Nick Lane talks Lex Fridman through hydrothermal vents, mitochondria, sex, consciousness, and why bacteria should be common while civilizations are not.
2:13:16ENLex Fridman· 23 juil. 2022Podcast · 2 voixEvery Atom in Your Body Was Forged in a Dead StarInvité : Martin Rees · Anime : Lex FridmanMartin Rees talks Lex Fridman through dark matter, alien life, one-way Mars trips, and why this century is the first in which one species holds the planet.
2:10:39ENLex Fridman· 1 juil. 2022Podcast · 2 voixDemis Hassabis: Solve Intelligence, Then Solve Everything ElseInvité : Demis Hassabis · Anime : Lex FridmanThe DeepMind CEO tells Lex Fridman why the Turing Test is the wrong exam, how AlphaFold rewrote biology, and why the quiet radio sky suggests we are probably alone.
2:55:05ENLex Fridman· 8 mai 2022Podcast · 2 voixExtinction awareness is the human trait Mason wants to carry to the starsInvité : Chris Mason · Anime : Lex FridmanCornell geneticist Chris Mason on why seeing our own end creates a duty to engineer life for other worlds — and what a 500-year plan would actually require.Charger plus24 sur 36 affichés