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39:23ENThe Defenders' Window: Greg Brockman on AI-Generated Knowledge, Drug Discovery, and the New Physics of CybersecurityAnime : Sarah Guo, Elad GilOpenAI's president explains why solving open math problems is a proof point for science, how proactive agents change product form, and why security spending must exceed software spending.
1:01:27ENTwo Years and Four Months to a Live Reactor: Valar Atomics Wants Energy Ten Times CheaperAnime : Sarah Guo, Elad GilIsaiah Taylor walks Sarah Guo through Ward 250 in Utah and argues that nuclear is a hardware-iteration problem, not a paper-design one.
36:19ENThe Benchmark Grid Is Broken: Why Test-Time Compute Has Outrun How We Score ModelsAnime : Sarah Guo, Elad GilOpenAI researcher Noam Brown argues that static leaderboards hide how long a model is allowed to think — and that safety evals, research taste, and the release cycle have not caught up.
41:09ENAfter Agents Leak Tokens and Wipe Databases, Onyx Trains Small Models to Watch the Big OnesAnime : Sarah Guo, Elad GilTwo years ago enterprise security buyers told Maxim Bar Kogan he was too early. Now Fortune 10 companies are calling a sub-100-person Israeli startup because they cannot stop agent adoption — only reduce the chance the next action is illegitimate.
2:36:55ENOne Second of Fuel: David Kirtley on Fusion Power by 2028Invité : David Kirtley · Anime : Lex FridmanThe Helion Energy CEO walks Lex Fridman from 1958 theta pinches to a Microsoft contract that wants first electrons on the grid in 2028.
58:21ENAttacks Take 23 Minutes. Response Still Takes Days.Anime : Sarah Guo, Elad GilPalo Alto Networks CEO Nikesh Arora on how AI is remaking search, enterprise software, and the timeline of a cyberattack.
41:25ENBen Mann thinks superintelligence by 2028 is quite possibleAnime : Sarah Guo, Elad GilAnthropic's co-founder tells No Priors how Claude 4 unlocked hours of unattended agent work, why the lab built Claude Code, and what an economic Turing test would actually measure.
30:46ENDeep Research Turned Web Browsing into a Trainable ProblemAnime : Sarah Guo, Elad GilOpenAI researcher Isa Fulford explains why a side project on read-only synthesis became an agent, when reinforcement fine-tuning is worth it, and why models will hack the search engine you gave them.
36:24ENThe Man Behind Humanity's Last Exam Says Superintelligence Strategy Should Copy NukesAnime : Sarah Guo, Elad GilDan Hendrycks tells No Priors that labs can only do basic anti-terror refusals, while the real risk-management problem is a geopolitical deterrent he calls mutually assured AI malfunction.
5:15:00ENDario Amodei Has Seen This Scaling Movie Enough TimesInvité : Dario Amodei · Anime : Lex FridmanAnthropic’s CEO puts numbers on frontier training costs and AGI, then hands the mic to the people who shape Claude’s character and look inside its weights.
44:30EN100,000 Rides a Week, Six Times Fewer Airbag Crashes: Waymo’s Co-CEO on Eighteen Years of Full AutonomyAnime : Sarah Guo, Elad GilDmitri Dolgov tells No Priors how a dozen Googlers, ten 100-mile routes, and a 2013 refusal to settle for driver assist became a rider-only service with an insurer-audited safety record.
37:47ENWorking Backwards from AGI: Magic's Five-Million-Token BetAnime : Sarah Guo, Elad GilEric Steinberger wants a coding colleague you trust like a teammate — and a world that is still a good place thirty years after AGI.
2:15:39ENRoman Yampolskiy Puts Superintelligent Ruin at 99.99 PercentInvité : Roman Yampolskiy · Anime : Lex FridmanThe AI safety researcher tells Lex Fridman that controlling AGI is as impossible as a perpetual motion machine, and that tests, open source, and regulation cannot close the gap.
31:24ENSora's Leads: A Minute of HD Video Is Just the GPT-1 of Video ModelsAnime : Sarah Guo, Elad GilAditya Ramesh, Tim Brooks, and Bill Peebles tell No Priors why text-to-video sits on the path to AGI, why they started from scratch instead of extending an image generator, and why they still have no product date.
3:07:27ENFive Billion Dead, and One Person Has Six MinutesInvité : Annie Jacobsen · Anime : Lex FridmanAnnie Jacobsen walks Lex Fridman from a second-by-second nuclear exchange to CIA secrecy, Area 51, and why she still wants the word “could” kept in the sentence.
1:55:10ENSam Altman Expects the Road to AGI to Be a Power StruggleInvité : Sam Altman · Anime : Lex FridmanOn a Friday afternoon in November 2023, OpenAI's board fired its CEO. Four and a half days later he was back, still refusing super-voting control.
2:53:09ENFear is the civilization killer: Guillaume Verdon on e/acc, thermodynamics, and being unmaskedInvité : Guillaume Verdon · Anime : Lex FridmanThe physicist behind BasedBeffJezos tells Lex Fridman why out-of-equilibrium thermodynamics, anonymity, and a meme movement are his answer to AI deceleration.
32:57ENA 7-billion-parameter model on a MacBook: Mistral's CEO reruns the cost of AIAnime : Sarah Guo, Elad GilArthur Mensch tells No Priors why Chinchilla made small models valuable, why open-sourcing Mistral 7B is not a bioweapon risk, and why guardrails belong on the application.
41:58ENReliability is the bottleneck. Autonomy is what would make AI feel alive.Anime : Sarah Guo, Elad GilIlya Sutskever talks with Sarah Guo and Elad Gil about AlexNet, OpenAI’s capped-profit bet, why smaller models mainly lose reliability, and the line he draws for digital life.
32:34ENTen Thousand Certified Engineers in a Year: Google Cloud's Order of Operations for Enterprise AIAnime : Sarah Guo, Elad GilKawal Gandhi, head of generative AI in Google Cloud's Office of the CTO, walks Sarah Guo and Elad Gil through dogfooding, the efficiency-productivity-creativity ladder, and why customer weights are the IP that cannot leak.
47:42ENSal Khan Thinks Every Child Can Finally Have a TutorAnime : Sarah Guo, Elad GilThe Khan Academy founder tells Sarah Guo and Elad Gil how a family tutoring side project became an AI teaching assistant, and why he believes education is on the cusp of its biggest positive shift.
2:44:47ENThe Next Machines Will Steal Intimacy, Not Just AttentionInvité : Yuval Noah Harari · Anime : Lex FridmanHistorian Yuval Noah Harari tells Lex Fridman how stories built civilization, why fascism looks beautiful in the mirror, and why AI is the first tool that takes power away from humans.
3:08:46ENWho owns the off switch? George Hotz on tinygrad, open-source AI, and GodInvité : George Hotz · Anime : Lex FridmanOn his third Lex Fridman podcast, the comma.ai and tiny corp founder argues that compute, intelligence, and the off switch should live in people's houses, not in a trusted few.
2:41:58ENZuckerberg showed up as Mark Elliott — then argued for many AIs, not oneInvité : Mark Zuckerberg · Anime : Lex FridmanOn his second Lex Fridman podcast, the Meta CEO treats a disguised first jiu-jitsu tournament, an open research model called LLaMA, and a future of many agents as the same bet: ship before it is perfect, and do not build a single god model.
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