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1:11:06ENReplit's Amjad Masad on Building Your Own Model, Latency, and the Next Billion Software CreatorsAnime : Jacob EffronThe Replit founder explains why AI should be native to the product, why he trained a small in-house model, and why he thinks software engineering is about to split in two.
1:22:43ENA Colleague With Its Own Computer: How a Small Team Built Grok Bot in a MonthAnime : Lenny RachitskyRoman Ugarte of SpaceXAI explains the decisions, hand-held onboarding and product philosophy behind Grok Bot, and what Cursor's culture taught him about staying ahead.
1:49:13ENThe Unfair Fight: How Breakthrough Startups Escape the PresentAnime : Lenny RachitskyMike Maples Jr. explains how breakthrough startups combine inflections, non-consensus insights, and founder-future fit, then act through movements, storytelling, and disagreeableness.
1:07:22ENCars That Drive Empty: Emilio Frazzoli on Why Self-Driving Needs Rules, Not Just DataAnime : Lex FridmanThe nuTonomy CTO explains why full autonomy and shared fleets are where the value lies, and why the hardest open problem is deciding how vehicles should behave.
1:10:19ENThe Robot That Folded the Laundry: Physical Intelligence’s Three FrontiersAnime : Jacob EffronKarol Hausman and Danny Driess explain how robot foundation models moved from coded primitives to web-scale pretraining, and why performance is now the hard gate.
1:50:25ENFrom Email Client to AI Agent: How Shortwave Rebuilt Itself for the Tidal WaveAnime : Nathan LabenzShortwave CEO Andrew Lee explains the agent architecture, caching economics and tiny-team culture behind the company's hockey-stick growth.
40:00ENThe Winds of Change: How Mistral Plans to Win the Open-Model EraAnime : Jacob EffronArthur Mensch explains Mistral's open-source strategy, enterprise distribution, model research, and views on AI regulation and sovereignty.
1:00:10ENThe Long Leash and the Narrow Fences: Eric Ries and Jeremy Howard on Building AI’s Edison LabAnime : Jacob EffronEric Ries and Jeremy Howard discuss Lean Startup discipline in AI, Answer.AI’s for-profit R&D lab model, efficient fine-tuning, language-heavy applications, and AI safety regulation.
1:09:00ENThe Meeting Is the Moat: Fireflies.ai’s Path to 16 Million UsersAnime : Jacob EffronKrish Ramani explains how Fireflies.ai turned AI note-taking into a meeting chief of staff, why he avoids fine-tuning, and how a startup competes with Microsoft, Zoom, and Google.
58:19ENRunway's Chris Valenzuela on Why Taste Beats Tools in Generative MediaAnime : Jacob EffronChris Valenzuela, CEO of Runway, explains why generative media is still early, how taste and iteration shape the work, and what has to change before AI media becomes a new art form.
54:05ENServal's Jake Stout on Outbuilding ServiceNow: Mirror the System of Record, Bet on Code, and Ship Before the Incumbent Can Book a MeetingAnime : Jacob EffronHow an AI-native employee-support startup attacks a legacy ITSM incumbent with velocity, code-generated workflows and a permissions-first architecture.
1:39:22ENRust-Proofing a Company: Eric Ries on Why Success Corrupts and Governance ProtectsAnime : Lenny RachitskyThe author of The Lean Startup explains why good companies go bad, and the charters, trusts and habits that keep a mission intact.
1:25:49ENShip Weekly, Cut Scope, and Keep a Secret Roadmap: How Captions Builds in the AI EraAnime : Lenny RachitskyGaurav Misra explains how a modern AI startup turns constant model progress into weekly shipped products, technical debt as leverage, and talking-video tools for non-professionals.
17:35ENHands Off the Wheel in San Diego: A Comma Two Demo Drive and a Tour of comma.ai's Hardware ShopAnime : Lex FridmanAfter their podcast conversation, George Hotz takes Lex Fridman on an openpilot drive and then through the comma.ai offices, dashboards, assembly line and compute cluster.
1:19:24ENLoops, Local Maxima and Ambition: Anish Acharya on How AI Rewires Companies and Consumer ProductsAnime : Lenny Rachitskya16z's Anish Acharya argues that companies will become stacks of AI loops guided by human intuition, and that the biggest consumer prize is a loop that makes people happier.
1:31:50ENZero to $80M in Six Months: How a Solo Founder Bootstrapped Base44 to a Wix ExitAnime : Lenny RachitskyMaor Shlomo explains how he built and grew the AI app builder Base44 without outside funding, the stack and habits that let one person compete with well-funded rivals, and how the Wix acquisition came together.
1:42:11ENTwenty Agents, 1.2 Humans: Inside SaaStr's AI-Run Sales TeamAnime : Lenny RachitskyJason Lemkin explains how SaaStr replaced a ten-person go-to-market team with AI agents, what it took to train them, and who survives the shift.
37:18ENFrom Intelligent Copilots to Aurora: Sterling Anderson on Shared Control and Building a Self-Driving CompanyAnime : Lex FridmanA guest lecture in MIT's 6.S094 course tracing Anderson's path from shared human-machine control research, through Tesla Autopilot, to co-founding Aurora.
51:45ENCameras Optional: HeyGen's Joshua Xu on Avatars, Orchestration and Building Ahead of the ModelsAnime : Jacob EffronHeyGen co-founder and CEO Joshua Xu explains how AI avatars are replacing the camera for business video, and how the company handles quality, trust and safety, and capital.
1:11:13ENAfter Code: Cursor's CEO on Logic Design, Custom Models and Why One Winner Will Take the MarketAnime : Lenny RachitskyMichael Truell explains how Cursor went from a mechanical-engineering pivot to a $300M ARR product, and where he thinks programming is heading.
18:32ENBuild a Lab Inside Your Product Team: Dan Shipper on Keeping Up With a Moving AI FrontierAnime : Lenny RachitskyEvery CEO Dan Shipper explains how a tiny, disposable-experiment lab can coexist with a focused product team, and how to move winners from one into the other.
45:00ENAgents Everywhere: OpenAI's Blueprint for Tool Use, Evals, and Computer-Use InfrastructureAnime : Jacob EffronOpenAI's API platform team explains how agents are moving from deterministic workflows to reasoning-driven tool use, and what developers still lack.
54:52ENCoding Agents Are Breaking Containment: The 2026 AI Stack, the Coding Wars, and the Next FrontierAnime : Jacob EffronJacob Effron and Swyx map the state of AI engineering, from agent harnesses and infrastructure churn to coding-market economics, open models, dark factories, and world models.
1:06:22ENPerplexity's Bet: Search Becomes Answers, and Answers Become a BusinessAnime : Jacob EffronThe Perplexity CEO explains how a consumer AI search product is built, sequenced, and defended against Google.
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