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14:41ENTalking for 20 Minutes: How the Alexa Prize Turns Real Customers into a Testbed for Conversational AIInvité : Rohit Prasad · Anime : Lex FridmanRohit Prasad, head scientist of Amazon Alexa, explains the Alexa Prize grand challenge, how it is judged and why true conversation still needs reasoning.
50:03ENCopilot Is a Copilot, Not a Pilot: Inbal Shani on the Future of AI in Software DevelopmentAnime : Lenny RachitskyGitHub's chief product officer explains what AI changes for developers, what it does not replace, and how teams should adopt it.
1:22:31ENPower Is a Tool: Stanford's Jeffrey Pfeffer on the Seven Rules of Getting AheadInvité : Jeffrey Pfeffer · Anime : Lenny RachitskyStanford organizational behavior professor Jeffrey Pfeffer walks Lenny Rachitsky through the seven rules of power, the homework that makes them stick, and the price power exacts.
1:45:55ENFrom Static Structures to Moving Molecules: Where AI for Protein Design Stands After AlphaFold 3Anime : Nathan LabenzComputational biochemist Amelie Schreiber walks Nathan Labenz through six months of progress in structure prediction, molecular dynamics, peptide and antibody models, and early agent-driven design workflows.
46:21ENForty-Eight Miles, Twelve Thank-Yous: Lex Fridman Takes On the Goggins ChallengeAnime : Lex FridmanLex Fridman runs four miles every four hours for 48 hours and records a gratitude reflection after each session.
1:17:25ENDon't Trust the Process: How Design Work Is Being Rebuilt Around Engineers and AgentsAnime : Lenny RachitskyClaude Cowork design lead Jenny Wen explains why the classic discovery-to-mock workflow is fading, what designers do instead, and who she wants to hire.
1:47:31ENFrom Fever Dream to Wilderness: Drew Houston on Dropbox's Three ErasInvité : Drew Houston · Anime : Lenny RachitskyDropbox's co-founder and CEO gives a candid account of explosive growth, the Google Photos shock, a painful pivot to productivity, and the personal and organizational reset that followed.
40:42ENDon't Mistake a Month of Hype for the End of SoftwareAnime : Sarah Guo, Elad GilSarah Guo and Elad Gil separate the SaaS-apocalypse noise from the real signals: record revenue ramps, collapsing token prices, and the question of when a founder should sell.
34:57ENIt's Six Months In: Misconceptions About AI, Regulation, Context Windows and IncumbentsAnime : Sarah Guo, Elad GilSarah Guo and Elad Gil answer listener questions on what the market gets wrong about generative AI, from the nuclear-regulation analogy to where startups can still beat incumbents.
2:01:57ENBuild the Sales Team Like a Founder: Jason Lemkin on Hiring, Comp and Keeping Product CloseInvité : Jason Lemkin · Anime : Lenny RachitskySaaStr founder Jason Lemkin walks through when to hire your first reps, who to hire, how to pay them, how product and sales should work together, and why customer-hostile tactics don't compound.
1:37:47ENYou Can Patch a Bug, but You Can't Patch a Brain: Why AI Guardrails FailInvité : Sander Schulhoff · Anime : Lenny RachitskyAdversarial-robustness researcher Sander Schulhoff explains why prompt injection and jailbreaks remain unsolved, why guardrail products don't deliver, and what teams can do instead.
2:53:45ENJoscha Bach on Seven Stages of Lucidity, Brutalist LLMs, and Why Life on Earth Isn't Only About HumansInvité : Joscha Bach · Anime : Lex FridmanA wide-ranging conversation on how minds are built, what language models are missing, and how an AI-saturated world might change consciousness, identity and risk.
17:40ENFrom AlphaGo Zero to MuZero: How Self-Play Strips Knowledge Out of AIAnime : Lex FridmanDeepMind's David Silver explains why removing human knowledge made AlphaZero stronger and more general, and how MuZero extended the idea to worlds with unknown rules.
53:39ENA Libertarian's Case for Regulating AI: Kill Switches, Chip Choke Points and a New Form of LifeAnime : Nathan LabenzLindy founder Flo Crivello explains why a self-described accelerationist makes an exception for superintelligence, and what he thinks of Biden's executive order.
1:18:22ENShipyards, Sharp Problems and Humility: Two Veteran Product Leaders on the PM Role in the AI EraAnime : Lenny RachitskyOji and Ezinne Udezue explain how product management is changing, which skills matter now, and what the companies winning with AI do differently.
1:41:44ENZig When Others Zag: HubSpot Co-founder Dharmesh Shah on Simplicity, Culture as a Product and Building a Company Around Your StrengthsInvité : Dharmesh Shah · Anime : Lenny RachitskyThe HubSpot co-founder and CTO explains why he has never had a direct report, how he measures laughs per minute, and the first-principles habits behind HubSpot's contrarian choices.
23:57ENChips, Agents and a Reckoning: Sarah Guo and Elad Gil on the 2023 AI BoomAnime : Sarah Guo, Elad GilThe hosts answer listener questions on the GPU crunch, how soon enterprises will ship AI products, how to build agents, and what 2024 holds for tech valuations.
1:02:49ENStop Being the Arrogant Doctor: Andy Raskin on Pitching a Movement, Not a ProductInvité : Andy Raskin · Anime : Lenny RachitskyStrategic narrative consultant Andy Raskin explains the five-part story structure behind pitches at Salesforce, Zuora and Gong, and how to make it your company's north star.
44:30ENOpen the Front Door: Emil Michael on Rebuilding U.S. Defense Around Startups, AI and Supply ChainsAnime : Sarah Guo, Elad GilThe Pentagon's research and engineering chief explains his six technology priorities, the rapid launch of GenAI.mil, and why new entrants and domestic manufacturing are now urgent.
1:10:32ENA Billion Dollars, No VC, Under 100 People: Surge AI's Edwin Chen on Data Quality and Where AI Is HeadingInvité : Edwin Chen · Anime : Lenny RachitskySurge AI's founder explains how a bootstrapped team built the leading human-data company, why he distrusts benchmarks, and how reinforcement learning environments are the next frontier.
1:07:22ENCars That Drive Empty: Emilio Frazzoli on Why Self-Driving Needs Rules, Not Just DataAnime : Lex FridmanThe nuTonomy CTO explains why full autonomy and shared fleets are where the value lies, and why the hardest open problem is deciding how vehicles should behave.
1:16:17ENFaster, But for What? Nicole Forsgren on Measuring Developer Productivity in the AI EraInvité : Nicole Forsgren · Anime : Lenny RachitskyThe creator of DORA and SPACE explains why most productivity metrics mislead, how AI changes flow and trust, and how to build a developer experience program that proves its value.
1:04:21ENOnboarding Is Growth's Biggest Lever: Lessons from Airtable's Former Head of GrowthInvité : Lauryn Isford · Anime : Lenny RachitskyLauryn Isford on rethinking experimentation, choosing a hard-to-reach activation metric, reverse trials, and the PLG funnel.
1:49:39ENNo Investors, 24 Profitable Years: Jason Fried on Staying Small, Trusting Your Gut and Making Money FirstInvité : Jason Fried · Anime : Lenny RachitskyThe 37signals co-founder explains how a 75-person, investor-free company has out-earned far larger rivals, and why he builds products in two-person, six-week cycles.
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