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1:08:22ENMark Doss on Production Engineering for High-Stakes TradingMark Doss · Jane StreetWhy every order matters, how event-based monitoring detects unexpected failures, and what a realistic incident reveals about trading operations.
58:46ENTwo Dates from OpenAI's Chief Scientist: Intern by September, Automated Researcher by 2028Anime : Jacob EffronJakub Pachocki tells Jacob Effron why those timelines still hold, why continual learning is not a detour, and why showing chain of thought in the product would train the monitor away.
2:03:23ENWe Have No King: How Viking Raiders Remade Medieval EuropeAnime : Lex FridmanHistorian Lars Brownworth walks Lex Fridman from Lindisfarne to Vinland, arguing that three centuries of raids were a lesson in speed, pragmatism, and creative destruction.
44:01ENA millionth of a penny: Jeremy Allaire on the payment rails of the agentic economyAnime : Sarah Guo, Elad GilCircle's CEO tells No Priors why stablecoins and a purpose-built chain, not the legacy banking stack, are the money layer for software that buys and sells on its own.
1:32:21ENAI Financing, Model Routing and Security Risks: A 20VC RoundtableInvité : Jason Lemkin, Rory O’Driscoll · Anime : Harry StebbingsJason Lemkin and Rory O’Driscoll debate reported OpenAI and Anthropic finances, model routing, database infrastructure and security, with attention to uncertainty and conflicts.
1:37:50ENGranola Added More Customers Than Almost Anyone by Being Surprisingly UnambitiousAnime : Nathan LabenzCo-founder Sam Stephenson tells Nathan Labenz how a calm notes app for frazzled meeting days, one Slack-sharing loop, and a refusal to promise the burning-fire work built a $1.5 billion company.
32:22ENDemis Hassabis on AGI, Scientific Discovery and the Challenges AheadInvité : Demis Hassabis · Anime : Harry StebbingsThe Google DeepMind CEO discusses compute, continual learning, safety standards and his hopes for AI in science, medicine and energy.
1:59ENHere.now and the Case for Agent-First Web PublishingMatthew Berman · Forward FutureMatthew Berman describes how a publishing service lets an AI agent put content online, and argues that the web is being rebuilt for agents.
1:57:29ENFrontier vision models score 12.5%: Joseph Nelson on the real waterline of computer visionAnime : Nathan LabenzThe Roboflow CEO tells Nathan Labenz why vision still lags language, how to distill SAM 3 into an edge model for Wimbledon, and why the United States has almost never led open-source vision.
1:03:40ENAndrew Dudum on Hims & Hers, Preventive Care and Building a Public CompanyInvité : Andrew Dudum · Anime : Harry StebbingsThe Hims & Hers CEO discusses management, healthcare distribution, marketing and expansion. His medical and commercial claims are presented as his views, not independently verified evidence.
29:26ENChatGPT Almost Became a Meeting Bot. Its Co-Creator Is Now Rearranging AtomsAnime : Sarah Guo, Elad GilLiam Fedus tells No Priors how Periodic Labs is connecting language models to experiments so materials science can run in a closed loop.
9:47ENGemma 4: Smaller Open-Weight Models for Local AIMatthew Berman · Forward FutureMatthew Berman reviews Google’s model sizes, multimodal features and reported benchmarks, with an eye toward local agents.
1:12:41ENAI Security, Revenue Claims and Wearable Economics: A 20VC Investor RoundtableInvité : Jason Lemkin, Rory O’Driscoll · Anime : Harry StebbingsHarry Stebbings, Jason Lemkin and Rory O’Driscoll debate AI product strategy, security spending, startup valuations and the durability of consumer subscriptions. Their discussion includes reported developments and unverified estimates, as well as O’Driscoll’s disclosure of an indirect Oura investment.
49:34ENBrad Lightcap on OpenAI’s Early Years, Agents and the Future of SoftwareInvité : Brad Lightcap · Anime : Jack AltmanThe OpenAI COO traces the shift from research to widely used products and discusses coding, startups, enterprise software and human oversight.
1:44:15ENNathan Labenz's p(doom) Is 10 to 90 Percent. He Is More Optimistic AnywayAnime : Nathan LabenzFive years ago, expecting AGI by 2035 made you an extremist. On The Intelligence Horizon, the Cognitive Revolution host explains why the same forecast now sounds bearish, and why he still thinks a defense-in-depth strategy might keep society on the rails.
27:15ENMeta-Harness: Searching for Better AI Agent InfrastructureMatthew Berman · Forward FutureMatthew Berman reviews a paper on using a coding agent to iteratively improve model harnesses and discusses its experimental limits.
1:16:32ENMarc Andreessen on Venture Investing, AI and the Work of BuildingInvité : Marc Andreessen · Anime : Harry StebbingsThe a16z co-founder discusses founder selection, venture economics, AI and why his firm has no current need to go public.
58:26ENGili Raanan on Venture Entry Prices, Growth and Private-Market LiquidityInvité : Gili Raanan · Anime : Harry StebbingsThe Cyberstarts founder explains his approach to cybersecurity investing, when he discusses margins and why secondary sales can help employees and limited partners.
1:19:18ENSeries A Fund Math, SpaceX Ambitions and the AI Valuation DebateInvité : Jason Lemkin, Rory O’Driscoll · Anime : Harry StebbingsHarry Stebbings, Jason Lemkin and Rory O’Driscoll examine AI competition, speculative space infrastructure and the rising cost of venture investing.
41:00ENRon Conway on Angel Investing, Founder Advocacy and the Power of RelationshipsInvité : Ron Conway · Anime : Jack AltmanThe SV Angel founder traces his path from semiconductors to seed investing and explains how he helps founders at critical moments.
46:35ENJon Gjengset on the Cost of Concurrency CoordinationJon GjengsetWhy shared cache lines can make even read-heavy locks slow, and how a different data structure trades writer work for scalable reads.
0:49ENMatthew Berman on OpenAI's Sora ShutdownMatthew Berman · Forward FutureA short reaction considers the end of the video app and asks what OpenAI's product focus means for other projects.
1:37:43ENCisco wants two extra network layers so agents can share intentAnime : Nathan LabenzVijoy Pandey of Outshift by Cisco argues that superintelligence has to scale out through networks of agents, not just up through bigger models.
58:27ENEven a dumber AI can win science if it never leaves the labGinkgo Bioworks CEO Jason Kelly tells Sequoia why autonomous labs, not smarter models, will change how experimental science gets done.
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