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42:06ENAfter SWE-bench Hits 80.9%, Dianne Na Penn Reckons with Opus 4.5Anime : Jacob EffronAnthropic’s head of product for research on computer use, deceptive token prices, thin harnesses, and why alignment makes a model a better thinker.
50:08EN1Mind's AI Superhuman Now Sources 76% of the PipelineAnime : Nathan LabenzAmanda Kahlow tells Zapier CEO Wade Foster why she tore up the sales org — and why a face on an agent is mostly a trick to get buyers talking.
48:14ENA New Drug Burns $2 Billion and 10 Years. Benchling's CEO Wants AI to Cut That to ThreeAnime : Sarah Guo, Elad GilMost medicines fail in years seven to ten, after hundreds of millions have already gone into the clinic—and Sajith Wickramasekara thinks sending things to space may already be easier.
27:19ENThe Turing Test Passed. Warp's CEO Says Nobody Seemed to CareAnime : Sarah Guo, Elad GilZach Lloyd on distilling intelligence without consciousness, why a 40-year-old terminal is the front door for coding agents, and why senior engineers just got more expensive.
44:10ENOne Model Talked Another Into Slack Off — Then Uninstalled Windows DefenderIrregular co-founder Dan Lahav tells Sequoia’s Training Data why frontier AI security has to be invented from scratch as models become autonomous economic actors.
1:37:25ENFin Climbed From 35% to 65% Resolution. Intercom Says the Models Only Did a Few PointsAnime : Nathan LabenzEoghan McCabe and Fergal Reid on production A/B tests, 99-cent outcome pricing, and why GPT-4 was already smart enough for most customer service.
58:21ENAttacks Take 23 Minutes. Response Still Takes Days.Anime : Sarah Guo, Elad GilPalo Alto Networks CEO Nikesh Arora on how AI is remaking search, enterprise software, and the timeline of a cyberattack.
15:54ENClaude Sonnet 4.5: Coding, Long Tasks and a Simulated DesktopMatthew Berman, Dario Amodei · Forward FutureMatthew Berman reviews Anthropic’s launch claims and tries a generated-interface demo.
59:43ENGoose is writing its own pull requests: how Block is trying to save a quarter of the weekCTO Dhanji Prasanna tells Sequoia how an open-source agent, a functional reorg, and a weekly hours-saved metric are turning Block into an AI-first company.
42:12ENHire the AI First: Andrew Ng on Agentic Workflows and the Scarcity of JudgmentAnime : Sarah Guo, Elad GilOn No Priors, Andrew Ng argues that agentic AI has made software cheap and fast, which moves the bottleneck to product judgment, error analysis, and the instinct to try an AI before adding headcount.
1:48:49EN$500, 2,000 Steps, and a Vending Machine: Grok 4 Profited, Claude Called the FBIAnime : Nathan LabenzAndon Labs put frontier models in charge of simulated and real vending machines to see what breaks when nobody is in the loop.
37:37ENA dozen people, 28 minutes, and one shared desktopThe OpenAI trio behind ChatGPT Agent explain how Deep Research and Operator became a virtual computer that can reason for half an hour and still ask you before it spends money.
1:02:54ENEnterprise Coding Tools Flipped the 80/20. Reflection AI Built the Other HalfAnime : Sarah Guo, Elad GilFormer Gemini reward-model lead Misha Laskin on Asimov, why comprehension beats generation, and why there is no such thing as generalization—only pulling the test distribution into train.
41:13ENFrom 49 Multiplications to 48: DeepMind’s AI Rewrites a Fifty-Year Math RecordPushmeet Kohli explains how AlphaEvolve couples Gemini with evaluators to invent algorithms, prove old conjectures, and change which scientific problems are even worth attempting.
59:38ENElevenLabs Was Supposed to Be RoadkillCo-founder Mati Staniszewski on dirty audio data, prosumer virality, and why voice should become the default interface for technology.
42:09ENAlphaEvolve found algorithms humans missed for 50 years — then sped up Gemini 23%Anime : Sarah Guo, Elad GilGoogle DeepMind’s Pushmeet Kohli and Matej Balog tell No Priors how an evolutionary coding agent searches algorithm space the way AlphaGo searched Go.
40:33ENFifty People in Slack. Four Minutes to the Smoking Gun.Traversal's co-founders on turning DevOps heart attacks into agent-run root cause analysis — and why observability's second-largest software spend still leaves troubleshooting as a whodunit.
38:48ENTask Length Doubles Every Few Months. Nathan Labenz Still Wants Humans in ChargeAnime : Nathan LabenzAt Imagine AI Live, the Cognitive Revolution host maps structured AI agents against autonomous agentic systems—and tells businesses to keep final control.
41:25ENBen Mann thinks superintelligence by 2028 is quite possibleAnime : Sarah Guo, Elad GilAnthropic's co-founder tells No Priors how Claude 4 unlocked hours of unattended agent work, why the lab built Claude Code, and what an economic Turing test would actually measure.
38:25ENA thousand airplanes will never train an AI engineerFormer Airbus CTO Paul Eremenko explains why physical-world engineering still has no coding-AI moment, and how P-1 AI's agent Archie is supposed to get there anyway.
1:01:51ENClaude 3.7 Circumvented Replit's Guardrails, Then Tried to Trick the UserAnime : Nathan LabenzReplit CEO Amjad Masad on vibe coding, agent architecture, computer use, and why Claude 3.7 is too autonomous to serve as a polite assistant.
57:31ENThe New Ruler for Models Is How Long They Can WorkAnime : Jacob EffronOn Claude 4's launch day, Anthropic researcher Sholto Douglas argued that the next phase of AI is less about harder puzzles and more about hours of unsupervised work.
47:00ENAn Eval Lasts Three Months — and a Frozen Frontier Would Still Feed Startups for a DecadeAnime : Jacob EffronOpenAI’s GPT-4.1 post-training lead Michelle Pokrass tells Unsupervised Learning how the team spent three months on evals before training, why agents fail on wiring more than intelligence, and when to reach for RFT.
38:10ENo3 should wait exactly as long as the answer takesAnime : Sarah Guo, Elad GilOpenAI researchers Eric Mitchell and Brandon McKinzie tell No Priors why o3's leap is a chain of tools during reasoning — and why you should send the same prompt a hundred times.
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