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48:14ENA New Drug Burns $2 Billion and 10 Years. Benchling's CEO Wants AI to Cut That to ThreeAnime : Sarah Guo, Elad GilMost medicines fail in years seven to ten, after hundreds of millions have already gone into the clinic—and Sajith Wickramasekara thinks sending things to space may already be easier.
1:26:42ENEverett Randle on Venture Fund Size, AI Margins and Founder PartnershipsInvité : Everett Randle · Anime : Harry StebbingsThe new Benchmark partner discusses lessons from former colleagues, investment trade-offs and the challenge of measuring AI businesses.
42:11ENSnowflake's CEO Tells Customers to Spend AI a Thousand Dollars at a TimeAnime : Sarah Guo, Elad GilSridhar Ramaswamy talks with Sarah Guo about Snowflake Intelligence, shutting down a homegrown model, and why defensibility is built every day, not planned.
59:03ENJoelle Pineau on Scaling, Reinforcement Learning and Enterprise AIInvité : Joelle Pineau · Anime : Harry StebbingsCohere’s chief AI officer discusses research uncertainty, agent security, synthetic data and the difference between benchmarks and useful work.
2:45:26ENDan Houser on Fake Worlds You Want to Live InInvité : Dan Houser · Anime : Lex FridmanThe Rockstar co-founder talks with Lex Fridman about GTA, Red Dead Redemption, character craft, leaving the company, and why language models will not write the last five percent.
18:59EN86 Out of 100: The Clips No Priors Could Not Leave on the Cutting-Room FloorAnime : Sarah Guo, Elad GilSarah Guo and Elad Gil stitch nine 2025 conversations into one short tour of legal AI, spatial intelligence, jobs, deterrence, and a doctor who made it home for dinner.
1:13:29ENDavid Cahn on AI Infrastructure, Startup Growth and Defense InvestingInvité : David Cahn · Anime : Harry StebbingsThe Sequoia partner explains why he sees an AI bubble, how he evaluates startup growth and where he sees opportunities in defense.
27:19ENThe Turing Test Passed. Warp's CEO Says Nobody Seemed to CareAnime : Sarah Guo, Elad GilZach Lloyd on distilling intelligence without consciousness, why a 40-year-old terminal is the front door for coding agents, and why senior engineers just got more expensive.
1:17:01ENDeel CEO Alex Bouaziz on Fundraising, Acquisitions and Global PayrollInvité : Alex Bouaziz · Anime : Harry StebbingsBouaziz discusses Deel’s financing, hands-on leadership, acquisition playbook and the company’s ambitions amid a dispute with Rippling.
31:57ENPeak 700 GW, average 300 GW: Base Power is wiring home batteries into a power plantAnime : Sarah Guo, Elad GilZach Dell tells Elad Gil how a $1.3 billion raise, a Texas-only retail business, and a Tesla-and-SpaceX hiring bench are meant to cut the cost of moving an electron.
2:42:06ENThe word 'evil' ends the conversationInvité : Julia Shaw · Anime : Lex FridmanCriminal psychologist Julia Shaw talks with Lex Fridman about the dark tetrad, serial killers, jealousy, bisexuality, and why generative AI is the ultimate false-memory machine.
1:03:45ENMike Cannon-Brookes on AI Valuations, Software Design and Building Atlassian to LastInvité : Mike Cannon-Brookes · Anime : Harry StebbingsThe Atlassian CEO explains why he expects more software engineers, how he evaluates AI bets, and why creativity matters across technology cycles.
36:58ENSTaR's Author Wants Models With EQ, Not Just More IQAnime : Sarah Guo, Elad GilEric Zelikman, the Stanford and xAI researcher behind STaR and Quiet-STaR, launches humans& on the bet that three years of IQ scaling left models emotionally unintelligent.
44:09ENGreg Brockman on Compute, Sora 2 and the Path to AGIMatthew Berman, Greg Brockman · Forward FutureMatthew Berman interviews OpenAI’s Greg Brockman about infrastructure constraints, proactive AI, developer risk and the future of work.
1:20:12ENCerebras CEO Andrew Feldman on AI Chips, Demand and Infrastructure RiskInvité : Andrew Feldman · Anime : Harry StebbingsFeldman discusses Cerebras financing, chip design and data centers, while weighing talent, energy and market concentration.
58:21ENAttacks Take 23 Minutes. Response Still Takes Days.Anime : Sarah Guo, Elad GilPalo Alto Networks CEO Nikesh Arora on how AI is remaking search, enterprise software, and the timeline of a cyberattack.
4:34:10ENPavel Durov Built Telegram for a Billion People. He Still Won't Carry a Phone.Invité : Pavel Durov · Anime : Lex FridmanIn a four-and-a-half-hour conversation with Lex Fridman, the Telegram founder traces freedom from a childhood move out of the Soviet Union to a French jail cell, a poisoning, and a 40-person engineering team.
1:31:19ENGroq Founder Jonathan Ross on AI Compute, Chip Competition and EnergyInvité : Jonathan Ross · Anime : Harry StebbingsRoss explains his view of inference demand, custom chips and infrastructure economics, and makes predictions about AI’s effects on markets and work.
1:01:49ENTwo Academic Hours a Day, and 96 Percent of Kids Say They Love SchoolAnime : Sarah Guo, Elad GilTrilogy founder Joe Liemandt, now principal of Alpha School, tells No Priors how an AI tutor, a two-hour bargain with fifth graders, and a sports-coach ethos are meant to scale to a billion children.
1:38:05ENHemant Taneja on Scaling General Catalyst, AI and the Future of VentureInvité : Hemant Taneja · Anime : Harry StebbingsThe General Catalyst CEO discusses early-stage returns, AI’s effect on work and the difficulty of investing through rapid technological change.
4:25:44ENThe Wehrmacht's Secret Ingredient Was MethamphetamineInvité : Norman Ohler · Anime : Lex FridmanHistorian Norman Ohler tells Lex Fridman how Pervitin, Hitler's doctor, and LSD change the story of World War II without turning drugs into a single cause.
31:22ENDecagon Prices AI Support by the Conversation. The Market Is Wages.Anime : Sarah Guo, Elad GilJesse Zhang on six-figure contracts at zero ARR, 60–70% contact-center cuts, and a world where your agent calls the airline’s agent.
1:00:35ENMercor CEO Brendan Foody on Expert Data, AI Evaluations and GrowthInvité : Brendan Foody · Anime : Harry StebbingsFoody explains Mercor’s marketplace, reported revenue run rate and views on model development, margins and company culture.
58:25ENA construction permit that took four months now takes three minutesAnime : Sarah Guo, Elad GilJared Kushner talks with Sarah Guo and Elad Gil about Affinity Partners, the AI firm BrainCo, and how capital, energy, and Middle East diplomacy now run through AI.
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