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32:22ENQwen Image Edit Plus Compared With Nano Banana, Seedream and GPT Image 1Matthew Berman · Forward FutureMatthew Berman compares four image-editing models across compositing, precise edits, style transfer, object removal and weather effects.
1:29:30EN2,500 Compounds and a 51 Percent Hit Rate: How a Small Graph Net Found New AntibioticsAnime : Nathan LabenzMIT's Jim Collins tells Nathan Labenz how a bootlegged 2018 project, a binary growth-inhibition label, and Chemprop graph networks pulled novel antibiotics out of chemical space that labs could never screen by hand.
36:58ENSTaR's Author Wants Models With EQ, Not Just More IQAnime : Sarah Guo, Elad GilEric Zelikman, the Stanford and xAI researcher behind STaR and Quiet-STaR, launches humans& on the bet that three years of IQ scaling left models emotionally unintelligent.
1:01:49ENChatGPT's Co-Creator Left to Put Nature in the Reward LoopAnime : Nathan LabenzLiam Fedus and Ekin Dogus Cubuk on why language models still fail at physics, why literature data is too noisy to train on, and why Periodic Labs is aiming at a 200K superconductor.
1:22:07ENEvery payment is a frame in a movie. Stripe’s foundation model took card-testing detection from 59% to 97%Anime : Nathan LabenzEmily Sands, Stripe’s head of data and AI, explains how a domain-specific payments model, shared embeddings, and mixed rules turn a $1.4 trillion network into compounding advantage.
2:02:17ENSAEs Find the Nouns. Parameter Decomposition Looks for the VerbsAnime : Nathan LabenzGoodfire's Lee Sharkey argues that sparse autoencoders recover a network's variables, not the algorithms those variables run, and shows how stochastic parameter decomposition tries to recover the computations themselves.
57:52ENThey Aimed for 1%. The Lab Hit 20%. Chai Discovery Moved Antibody Design Onto the Computer.Anime : Jacob EffronJoshua Meier on three waves of AI drug discovery, why Chai-2 behaves like Photoshop for molecules, and why a 1% hit rate was supposed to be enough to change the industry.
40:32ENMark Chen on GPT-5, Synthetic Data and the Future of AI ResearchMatthew Berman, Mark Chen · Forward FutureOpenAI’s head of research discusses training, agents, open-weight releases and evaluation with Matthew Berman in August 2025.
30:11ENFrom 12 Percent on AIME to IMO Gold in Two MonthsAlex Wei, Sheryl Hsu, and Noam Brown tell Sequoia's Sonya Huang how a three-person OpenAI sprint used general-purpose reinforcement learning, not Lean, to reach gold-level on the 2025 International Mathematical Olympiad.
1:07:41ENEdwin Chen on Building Surge and the Data Behind AI ModelsInvité : Edwin Chen · Anime : Harry StebbingsThe Surge founder discusses a bootstrapped business, training-data quality and the limits he sees in AI benchmarks and synthetic data.
47:05ENLogan Kilpatrick on AI Developers, Interfaces, and the Future of ModelsMatthew Berman, Logan Kilpatrick · Forward FutureIn a July 2025 conversation, Google’s Logan Kilpatrick discusses Windsurf, agent interfaces, coding skills, Veo, and the shifting boundary between models and application scaffolding.
49:55ENAravind Srinivas on Comet, AI Browsers and the Future of WorkMatthew Berman, Aravind Srinivas · Forward FuturePerplexity’s CEO explains why the company built a browser, how it evaluates models and why he expects AI to disrupt jobs.
38:10ENPlus Five for Format, Plus Ten if It CompilesAnime : Nathan LabenzPredibase CEO Dev Rishi explains how reinforcement fine-tuning, production feedback, and narrow specialist models turn one-off training into systems that keep learning.
1:42:06ENEvery Frontier Lab Is Spending a Billion a Year on Data. Here Is Where It GoesAnime : Nathan LabenzLabelbox CEO Manu Sharma on the $15 billion Scale deal, RL “gyms,” $250,000 trainers, and why post-training now eats the budget that used to belong to pre-training.
1:37:05ENAn Algebraic Geometer Quit Tenure Because the Bowl-Shaped Loss Plot Is a LieAnime : Nathan LabenzJesse Hoogland and Daniel Murfet of Timaeus argue that singularities in the loss landscape — not the smooth valleys in every slide deck — are what actually govern how neural networks learn, generalize, and go wrong.
48:51ENThe Breakthroughs for AGI Are Already Done, Says OpenAI’s Former Research HeadBob McGrew tells Sequoia’s Training Data that 2025 is the year of reasoning, agents will be priced at the cost of compute, and nothing fundamental will be added to the stack by 2035.
1:54:08ENWhy Anthropic's first check went to a company building microscopes for neural netsAnime : Nathan LabenzGoodfire's Dan Balsam and Tom McGrath argue that mechanistic interpretability now has a proto-paradigm, two stubborn gaps, and three products worth shipping today.
2:12:00ENGradient Descent at Test Time: Titans Pushes LLM Context to 10 Million TokensAnime : Nathan LabenzA Cornell PhD student's neural memory module holds about 70% accuracy where GPT-4's scores fall off a cliff.
47:00ENAn Eval Lasts Three Months — and a Frozen Frontier Would Still Feed Startups for a DecadeAnime : Jacob EffronOpenAI’s GPT-4.1 post-training lead Michelle Pokrass tells Unsupervised Learning how the team spent three months on evals before training, why agents fail on wiring more than intelligence, and when to reach for RFT.
38:10ENo3 should wait exactly as long as the answer takesAnime : Sarah Guo, Elad GilOpenAI researchers Eric Mitchell and Brandon McKinzie tell No Priors why o3's leap is a chain of tools during reasoning — and why you should send the same prompt a hundred times.
58:11ENPatrick Hsu Wants an App Store for Biology, Not Just Better DrugsThe Arc Institute co-founder argues that Evo 2, trained on genomes rather than proteins, should underpin tools for every step of the scientific method.
2:29:41ZH陈建宇:机器人基座模型如何走向通用 VLAInvité : 陈建宇 · Anime : 张小珺从 SayCan、RT-2 到 Diffusion Policy,清华助理教授、星动纪元创始人陈建宇梳理机器人模型从借用语言模型到端到端 VLA 的路线。关键难题仍是多样化数据、跨本体泛化和高频动作控制。
1:14:11ENThe Reasoning Curve Was Smooth All Along: Gemini 2.5's Jack Rae on Thinking, Memory, and AGIAnime : Nathan LabenzDeepMind's thinking-and-inference lead explains why RL-for-reasoning felt sudden, why Gemini shows raw chain of thought, and why a million-token window still is not memory.
1:43:54ENA Year to Grow a Brain Organoid, an Hour to Simulate ItAnime : Nathan LabenzStanford postdoc Siyu He tells Nathan Labenz how Squidiff and CORAL move single-cell and spatial experiments into the computer — and where the models still cannot go.
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