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58:21ENAttacks Take 23 Minutes. Response Still Takes Days.Anime : Sarah Guo, Elad GilPalo Alto Networks CEO Nikesh Arora on how AI is remaking search, enterprise software, and the timeline of a cyberattack.
15:54ENClaude Sonnet 4.5: Coding, Long Tasks and a Simulated DesktopMatthew Berman, Dario Amodei · Forward FutureMatthew Berman reviews Anthropic’s launch claims and tries a generated-interface demo.
4:34:10ENPavel Durov Built Telegram for a Billion People. He Still Won't Carry a Phone.Invité : Pavel Durov · Anime : Lex FridmanIn a four-and-a-half-hour conversation with Lex Fridman, the Telegram founder traces freedom from a childhood move out of the Soviet Union to a French jail cell, a poisoning, and a 40-person engineering team.
10:50ENSora 2: Generated Video, Sound and Cameos in an Early DemonstrationMatthew Berman · Forward FutureMatthew Berman reviews launch examples and tries the early web and mobile experience, noting both visual realism and artifacts.
1:31:19ENGroq Founder Jonathan Ross on AI Compute, Chip Competition and EnergyInvité : Jonathan Ross · Anime : Harry StebbingsRoss explains his view of inference demand, custom chips and infrastructure economics, and makes predictions about AI’s effects on markets and work.
1:01:49ENTwo Academic Hours a Day, and 96 Percent of Kids Say They Love SchoolAnime : Sarah Guo, Elad GilTrilogy founder Joe Liemandt, now principal of Alpha School, tells No Priors how an AI tutor, a two-hour bargain with fifth graders, and a sports-coach ethos are meant to scale to a billion children.
1:38:05ENHemant Taneja on Scaling General Catalyst, AI and the Future of VentureInvité : Hemant Taneja · Anime : Harry StebbingsThe General Catalyst CEO discusses early-stage returns, AI’s effect on work and the difficulty of investing through rapid technological change.
4:25:44ENThe Wehrmacht's Secret Ingredient Was MethamphetamineInvité : Norman Ohler · Anime : Lex FridmanHistorian Norman Ohler tells Lex Fridman how Pervitin, Hitler's doctor, and LSD change the story of World War II without turning drugs into a single cause.
31:22ENDecagon Prices AI Support by the Conversation. The Market Is Wages.Anime : Sarah Guo, Elad GilJesse Zhang on six-figure contracts at zero ARR, 60–70% contact-center cuts, and a world where your agent calls the airline’s agent.
1:00:35ENMercor CEO Brendan Foody on Expert Data, AI Evaluations and GrowthInvité : Brendan Foody · Anime : Harry StebbingsFoody explains Mercor’s marketplace, reported revenue run rate and views on model development, margins and company culture.
58:25ENA construction permit that took four months now takes three minutesAnime : Sarah Guo, Elad GilJared Kushner talks with Sarah Guo and Elad Gil about Affinity Partners, the AI firm BrainCo, and how capital, energy, and Middle East diplomacy now run through AI.
1:22:04ENElevenLabs CEO Mati Staniszewski on Voice AI, Growth and Building from EuropeInvité : Mati Staniszewski · Anime : Harry StebbingsStaniszewski discusses the company’s origins in dubbing, its financing and reported ARR, and the challenges of scaling voice products.
44:49ENHow OpenEvidence Became the Clinical OS for 40% of U.S. DoctorsAnime : Sarah Guo, Elad GilFounder Daniel Nadler tells No Priors how a free search tool for physicians, not an answer engine for patients, took high-stakes clinical knowledge in 18 months.
1:12:58ENChris Lattner on Mojo and the Search for Portable GPU PerformanceYaron Minsky, Chris Lattner · Jane StreetRon Minsky and Chris Lattner discuss the language and compiler design behind Modular’s effort to make accelerator programming both portable and fast.
3:36:25ENT. rex Was an Orca on Land. Almost Nothing Else Matches the Movies.Invité : Dave Hone · Anime : Lex FridmanPaleontologist Dave Hone walks Lex Fridman through T. rex size, bone-crushing anatomy, hunting, extinction, and what Jurassic Park still gets wrong.
1:14:39ENNick Frosst on Cohere’s Enterprise AI Strategy and the Limits of HypeInvité : Nick Frosst · Anime : Harry StebbingsThe Cohere co-founder discusses data, benchmarks, workplace automation and why he challenges popular claims about AGI.
1:50:28ENThe 87-Kilobyte Program Two Billion People Open Every MonthInvité : Dave Plummer · Anime : Lex FridmanDave Plummer talks Lex Fridman through Task Manager, old-school Microsoft, and how an autistic mind actually works.
40:54ENSeventeen Years of Flat Power, and a Plan to Bring the Factories HomeAnime : Sarah Guo, Elad GilJacob Helberg, the under secretary of state designate for economic growth, energy, and the environment, argues that nuclear power and AI productivity—not cheap labor—are how America reshore its supply chain.
1:01:23ENWill Crichton on Making Rust More UnderstandableWill Crichton · Brown UniversityOwnership visualizations, interactive trait diagnostics and program slicing illustrate an evidence-based approach to developer tools.
20:05ENAI News: Macrohard, Comet Plus and the Debate Over AI WelfareMatthew Berman, Dara Khosrowshahi · Forward FutureMatthew Berman reviews August 2025 AI news, from generative worlds and publisher payments to robotics, Intel and enterprise AI results.
1:23:11ENBessemer’s Byron Deeter on AI Growth, Venture Scale and LiquidityInvité : Byron Deeter · Anime : Harry StebbingsDeeter discusses AI software economics, follow-on investments and the trade-offs facing venture firms and their limited partners.
10:26:31ENThe War on Terror's Only Gift Was Better Luke Skywalker HandsInvité : Scott Horton · Anime : Lex FridmanScott Horton walks Lex Fridman through fifty years of U.S. wars, from Vietnam Syndrome to Ukraine, and argues the machinery never stops because it is not supposed to.
42:12ENHire the AI First: Andrew Ng on Agentic Workflows and the Scarcity of JudgmentAnime : Sarah Guo, Elad GilOn No Priors, Andrew Ng argues that agentic AI has made software cheap and fast, which moves the bottleneck to product judgment, error analysis, and the instinct to try an AI before adding headcount.
1:14:08ENLovable CEO Anton Osika on AI App Building, Economics and SecurityInvité : Anton Osika · Anime : Harry StebbingsOsika discusses Lovable’s reported growth, model costs and product strategy while Stebbings challenges its defensibility and security.
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