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1:44:35ENJoe Hudson: $500 Billion Went Into AI, and Nobody Defined 'Good for Humanity'Anime : Nathan LabenzSam Altman says the OpenAI coach's superpower is emotional clarity — and that it will be one of the most critical skills in a post-AGI world.
1:34:12ENOpenAI Secondaries, Ramp and the Price of AI GrowthInvité : Jason Lemkin, Rory O’Driscoll, Jeff Lawson · Anime : Harry StebbingsJason Lemkin, Rory O’Driscoll and Jeff Lawson join Harry Stebbings to debate AI funding, founder incentives and the risks of moving too fast.
59:06ENInference Costs Fell 100x. Tri Dao Says There's Another 10x — and NVIDIA's 90% Won't HoldAnime : Jacob EffronThe FlashAttention author and Together AI chief scientist on why hardware portability is a myth, how Claude Code made him 1.5x faster, and why workloads will split the chip market.
43:09ENA $100 Arm and a $300 Robot: Hugging Face Wants an App Store for Physical AIThomas Wolf tells Sequoia's Training Data why LeRobot, cheap hardware, and open datasets are Hugging Face's bet that software developers can become roboticists.
1:22:04ENElevenLabs CEO Mati Staniszewski on Voice AI, Growth and Building from EuropeInvité : Mati Staniszewski · Anime : Harry StebbingsStaniszewski discusses the company’s origins in dubbing, its financing and reported ARR, and the challenges of scaling voice products.
3:14:49ENNothing This Summer Jumped the Curve: Why Zvi Lengthened His AGI TimelinesAnime : Nathan LabenzOn his tenth visit to The Cognitive Revolution, Zvi Mowshowitz argues that GPT-5 and IMO gold stayed on trend, while chip policy, energy, and reinforcement learning nudged his p(doom) slightly up.
44:49ENHow OpenEvidence Became the Clinical OS for 40% of U.S. DoctorsAnime : Sarah Guo, Elad GilFounder Daniel Nadler tells No Priors how a free search tool for physicians, not an answer engine for patients, took high-stakes clinical knowledge in 18 months.
1:14:45ENAnthropic, Statsig and the Economics of AI Growth: Cliff Obrecht and 20VCInvité : Cliff Obrecht, Jason Lemkin, Rory O’Driscoll · Anime : Harry StebbingsCanva’s Cliff Obrecht joins Harry Stebbings and investors to discuss AI financing, employee liquidity and the real cost of putting models into software.
1:12:58ENChris Lattner on Mojo and the Search for Portable GPU PerformanceYaron Minsky, Chris Lattner · Jane StreetRon Minsky and Chris Lattner discuss the language and compiler design behind Modular’s effort to make accelerator programming both portable and fast.
3:36:25ENT. rex Was an Orca on Land. Almost Nothing Else Matches the Movies.Invité : Dave Hone · Anime : Lex FridmanPaleontologist Dave Hone walks Lex Fridman through T. rex size, bone-crushing anatomy, hunting, extinction, and what Jurassic Park still gets wrong.
1:51:39ENA native ad engine for AI—and the questions it cannot dodgeAnime : Nathan LabenzRyan Hudson, who sold Honey to PayPal for $4 billion, joins Nathan Labenz to explain ZeroClick’s bet on paid inference-time ads, and the societal incentives he has not yet had to confront.
50:00ENCrosby Bills by the Document, Not the Hour, and Turns Contracts Around in Under an HourThe founders of an AI-native law firm explain why they became lawyers with engineers at the next desk instead of shipping legal software, and how deal velocity became the product.
1:14:39ENNick Frosst on Cohere’s Enterprise AI Strategy and the Limits of HypeInvité : Nick Frosst · Anime : Harry StebbingsThe Cohere co-founder discusses data, benchmarks, workplace automation and why he challenges popular claims about AGI.
1:55:02ENA hundred experiments a day, and the valley of death in materialsAnime : Nathan LabenzRadical AI’s co-founders tell Nathan Labenz how a closed loop of frontier models and a self-driving lab is meant to collapse a forty-year materials cycle into less than a decade.
1:50:28ENThe 87-Kilobyte Program Two Billion People Open Every MonthInvité : Dave Plummer · Anime : Lex FridmanDave Plummer talks Lex Fridman through Task Manager, old-school Microsoft, and how an autistic mind actually works.
40:54ENSeventeen Years of Flat Power, and a Plan to Bring the Factories HomeAnime : Sarah Guo, Elad GilJacob Helberg, the under secretary of state designate for economic growth, energy, and the environment, argues that nuclear power and AI productivity—not cheap labor—are how America reshore its supply chain.
17:51ENAI News in August 2025: Claude for Chrome, New Models and AI InfrastructureMatthew Berman · Forward FutureMatthew Berman reviews a browser-agent preview, model releases, reported Apple discussions and research on inference and weather.
1:14:44ENMarc Benioff on Enterprise AI, Anthropic’s Funding and Klarna’s IPOInvité : Marc Benioff, Jason Lemkin, Rory O’Driscoll · Anime : Harry StebbingsThe Salesforce CEO joins Harry Stebbings, Jason Lemkin and Rory O’Driscoll to discuss AI agents, software growth and the economics of today’s venture market.
2:02:17ENSAEs Find the Nouns. Parameter Decomposition Looks for the VerbsAnime : Nathan LabenzGoodfire's Lee Sharkey argues that sparse autoencoders recover a network's variables, not the algorithms those variables run, and shows how stochastic parameter decomposition tries to recover the computations themselves.
1:01:23ENWill Crichton on Making Rust More UnderstandableWill Crichton · Brown UniversityOwnership visualizations, interactive trait diagnostics and program slicing illustrate an evidence-based approach to developer tools.
18:31ENTesting Nano Banana: Gemini 2.5 Flash Image EditingMatthew Berman · Forward FutureMatthew Berman tests character consistency, image edits, generation, visual sequences and common failure cases.
35:45ENSix Years of Revenue, Then Four Times That in Eight Monthsn8n CEO Jan Oberhauser tells Sequoia how two bets — becoming an AI-agent builder, then deleting the leads metric — turned a workflow tool into a default orchestration layer.
1:23:11ENBessemer’s Byron Deeter on AI Growth, Venture Scale and LiquidityInvité : Byron Deeter · Anime : Harry StebbingsDeeter discusses AI software economics, follow-on investments and the trade-offs facing venture firms and their limited partners.
10:26:31ENThe War on Terror's Only Gift Was Better Luke Skywalker HandsInvité : Scott Horton · Anime : Lex FridmanScott Horton walks Lex Fridman through fifty years of U.S. wars, from Vietnam Syndrome to Ukraine, and argues the machinery never stops because it is not supposed to.
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