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2:39:45ENThe obesity gene was never the obesity geneInvité : Manolis Kellis · Anime : Lex FridmanManolis Kellis tells Lex Fridman how one nucleotide a million bases from FTO rewrote obesity biology, and why human genetics is now driving the study of disease.
3:12:55ENThe IQ required to destroy the world drops by one point every yearInvité : George Hotz · Anime : Lex FridmanGeorge Hotz on Fermi's paradox, hacking the simulation, and teaching cars to drive with neural nets.
2:46:57ENProgramming Languages Are Bicycles for the MindInvité : Chris Lattner · Anime : Lex FridmanChris Lattner talks with Lex Fridman about Swift, LLVM, RISC-V, and why the next leap in computing is as much a language problem as a silicon one.
44:34ENChris Perl on Keeping Network Clocks in SyncYaron Minsky, Chris Perl · Jane StreetHow NTP, PTP and hardware timestamps work together to keep Jane Street’s clocks within a measurable error bound.
1:56:31ENA Blank Wall Is Not More Conscious Than a PersonInvité : Scott Aaronson · Anime : Lex FridmanScott Aaronson walks Lex Fridman through integrated information theory, Penrose’s uncomputable mind, GPT-3, P versus NP, and why silent support for open discourse has to get louder.
59:33ENLaurent Mazare on Python, OCaml and Machine LearningYaron Minsky, Laurent Mazare · Jane StreetA researcher compares exploratory notebooks with robust production systems, and explains how language interoperability and resource management connect the two.
2:23:38ENThe Brain That Never Touches the WorldInvité : Lisa Feldman Barrett · Anime : Lex FridmanNeuroscientist Lisa Feldman Barrett tells Lex Fridman why your skull is a dark box, why emotions are constructed like money, and why empathy is a metabolic bill.
3:23:56ENThose Who Need Leaders Are Not Qualified to Choose ThemInvité : Michael Malice · Anime : Lex FridmanAnarchist writer Michael Malice tells Lex Fridman how he defines love, why mockery is Batman’s job, and why anarchism is a relationship rather than a utopia.
1:10:27ENGreta Yorsh on Compiler Optimization and FeedbackYaron Minsky, Greta Yorsh · Jane StreetFrom formal verification and superoptimization to profile-guided code layout, a compiler engineer explains how performance work meets real users.
1:19:11ENJoe Rogan Spent Seven Hours on an EllipticalInvité : Joe Rogan · Anime : Lex FridmanIn a 2020 conversation with Lex Fridman, he talks through death, a country already at an eight, and the lock he built around a competitive demon that never left.
1:51:01ENJames Gosling Built Java to Make Pointer Bugs Impossible. Chrome Still Has Them.Invité : James Gosling · Anime : Lex FridmanIn a 2020 conversation with Lex Fridman, Java’s designer traces a line from a neglected PDP-8 to Emacs, the JVM, and a thirty-year war on memory errors.
1:02:18ENBrian Nigito on Multicast and the Architecture of MarketsYaron Minsky, Brian Nigito · Jane StreetWhy exchanges use ordered event streams, multicast and specialized networking to distribute market data quickly and fairly.
3:48:14ENIf You Cannot Cause Harm, You Are Forever Subject to Those Who CanInvité : Ryan Hall · Anime : Lex FridmanUFC fighter and jiu-jitsu black belt Ryan Hall talks with Lex Fridman about warriors, grace, coaching, and the thin social contract that keeps violence in check.
59:26ENAndy Ray on FPGAs, Hardware Design and HardcamlYaron Minsky, Andy Ray · Jane StreetJane Street’s hardware design lead explains why programmable circuits can improve performance and how software tooling makes them easier to build and test.
4:23:39ENThe Universe's Rule Might Fit on a PostcardInvité : Stephen Wolfram · Anime : Lex FridmanStephen Wolfram tells Lex Fridman how a short computational rule on a hypergraph could generate space, time, relativity, and quantum mechanics.
2:10:53ENAll Your DNA Would Reach Jupiter a Hundred Times OverInvité : Manolis Kellis · Anime : Lex FridmanManolis Kellis talks Lex Fridman through the epigenome, Neanderthals, Europa, midlife, and why "are you happy?" is the wrong question.
1:16:15ENAll-In E7: California, Gig Work and the SPAC BoomAnime : Jason Calacanis, Chamath Palihapitiya, David Sacks, David FriedbergFour investors debate California policy, police reform, markets and the 2020 election.
3:56:24ENThe Tic-Tac Knew We Were ThereInvité : David Fravor · Anime : Lex FridmanNavy commander David Fravor tells Lex Fridman what four Super Hornet aircrew saw off the USS Nimitz in 2004, why he does not buy a secret human aircraft, and how an unexplained object never made anyone's to-do list.
3:01:07ENLoneliness Has No Clinic. Eugenia Kuyda Built an AI Friend AnywayInvité : Eugenia Kuyda · Anime : Lex FridmanThe Replika co-founder talks with Lex Fridman about grief, conversation, and why memory—not a clever reply—is the real limit of AI companionship.
2:34:20ENIntelligence Is How Efficiently You Acquire Skills You Were Not Prepared ForInvité : François Chollet · Anime : Lex FridmanFrançois Chollet tells Lex Fridman why skill is not intelligence, why GPT-3 is still pattern matching, and why a grid puzzle called ARC still separates children from machines.
1:41:24ENA child can lose half a brain. The rest will rewire around the jobInvité : David Eagleman · Anime : Lex FridmanNeuroscientist David Eagleman tells Lex Fridman why the human brain is not hardware running software, but a livewired system that never stops physically reshaping itself.
2:08:26ENSatisfying Lectures Don't Stick: Grant Sanderson on Feynman, Fear, and Hitting PublishInvité : Grant Sanderson · Anime : Lex FridmanThe 3Blue1Brown creator talks with Lex Fridman about why the nicest explanations can fail, why he envies Bell Labs, and why the experts most qualified to teach are the ones least willing to post.
2:56:24ENIt Is Knowing We Will Die That Makes Us HumanInvité : Sheldon Solomon · Anime : Lex FridmanSheldon Solomon tells Lex Fridman how death anxiety, from an eight-year-old's stamp collection to 28-millisecond lab primes, quietly runs politics, religion, and everyday life.
1:41:35ENThe Smallest Lights: Sara Seager on Finding Life Beyond the SunInvité : Sara Seager · Anime : Lex FridmanThe MIT planetary scientist talks with Lex Fridman about exoplanets, biosignature gases, a flower-shaped starshade, and the grief that sent her looking for another Earth.
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