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39:23ENThe Defenders' Window: Greg Brockman on AI-Generated Knowledge, Drug Discovery, and the New Physics of CybersecurityPresenta: Sarah Guo, Elad GilOpenAI's president explains why solving open math problems is a proof point for science, how proactive agents change product form, and why security spending must exceed software spending.
1:01:27ENTwo Years and Four Months to a Live Reactor: Valar Atomics Wants Energy Ten Times CheaperPresenta: Sarah Guo, Elad GilIsaiah Taylor walks Sarah Guo through Ward 250 in Utah and argues that nuclear is a hardware-iteration problem, not a paper-design one.
36:19ENThe Benchmark Grid Is Broken: Why Test-Time Compute Has Outrun How We Score ModelsPresenta: Sarah Guo, Elad GilOpenAI researcher Noam Brown argues that static leaderboards hide how long a model is allowed to think — and that safety evals, research taste, and the release cycle have not caught up.
41:09ENAfter Agents Leak Tokens and Wipe Databases, Onyx Trains Small Models to Watch the Big OnesPresenta: Sarah Guo, Elad GilTwo years ago enterprise security buyers told Maxim Bar Kogan he was too early. Now Fortune 10 companies are calling a sub-100-person Israeli startup because they cannot stop agent adoption — only reduce the chance the next action is illegitimate.
2:36:55ENOne Second of Fuel: David Kirtley on Fusion Power by 2028Invitado: David Kirtley · Presenta: Lex FridmanThe Helion Energy CEO walks Lex Fridman from 1958 theta pinches to a Microsoft contract that wants first electrons on the grid in 2028.
18:59EN86 Out of 100: The Clips No Priors Could Not Leave on the Cutting-Room FloorPresenta: Sarah Guo, Elad GilSarah Guo and Elad Gil stitch nine 2025 conversations into one short tour of legal AI, spatial intelligence, jobs, deterrence, and a doctor who made it home for dinner.
58:21ENAttacks Take 23 Minutes. Response Still Takes Days.Presenta: Sarah Guo, Elad GilPalo Alto Networks CEO Nikesh Arora on how AI is remaking search, enterprise software, and the timeline of a cyberattack.
1:32:16ZH王忻谈奔驰中国研发:在转型中重划豪华与安全Invitado: 王忻 · Presenta: 张小珺奔驰中国研发负责人王忻回顾中国汽车产业二十年的技术周期,也讲述中国团队如何从测试支持走向产品研发。面对智能化竞争,他认为速度、数据和本地化必须建立在安全与用户体验之上。
41:25ENBen Mann thinks superintelligence by 2028 is quite possiblePresenta: Sarah Guo, Elad GilAnthropic's co-founder tells No Priors how Claude 4 unlocked hours of unattended agent work, why the lab built Claude Code, and what an economic Turing test would actually measure.
30:46ENDeep Research Turned Web Browsing into a Trainable ProblemPresenta: Sarah Guo, Elad GilOpenAI researcher Isa Fulford explains why a side project on read-only synthesis became an agent, when reinforcement fine-tuning is worth it, and why models will hack the search engine you gave them.
36:24ENThe Man Behind Humanity's Last Exam Says Superintelligence Strategy Should Copy NukesPresenta: Sarah Guo, Elad GilDan Hendrycks tells No Priors that labs can only do basic anti-terror refusals, while the real risk-management problem is a geopolitical deterrent he calls mutually assured AI malfunction.
1:02:41ENMike Krieger on AI Products, Model Competition and the Future of CodingInvitado: Mike Krieger · Presenta: Harry StebbingsAnthropic’s chief product officer explains how he thinks about product design, model differentiation and the limits of current AI tools.
1:23:45ENShervin Pishevar on Uber, Venture Capital and a Disputed Leadership CrisisInvitado: Shervin Pishevar · Presenta: Harry StebbingsThe investor recounts his Uber investment and offers his perspective on the company’s 2017 leadership conflict, alongside views on venture capital and emerging technology.
1:01:48ENReid Hoffman on Trade, AI, Energy and the Incoming Trump AdministrationInvitado: Reid Hoffman · Presenta: Harry StebbingsThe investor discusses political risks and opportunities, competition in AI, nuclear energy and the role of venture capital in a wide-ranging December 2024 interview.
5:15:00ENDario Amodei Has Seen This Scaling Movie Enough TimesInvitado: Dario Amodei · Presenta: Lex FridmanAnthropic’s CEO puts numbers on frontier training costs and AGI, then hands the mic to the people who shape Claude’s character and look inside its weights.
44:30EN100,000 Rides a Week, Six Times Fewer Airbag Crashes: Waymo’s Co-CEO on Eighteen Years of Full AutonomyPresenta: Sarah Guo, Elad GilDmitri Dolgov tells No Priors how a dozen Googlers, ten 100-mile routes, and a 2013 refusal to settle for driver assist became a rider-only service with an insurer-audited safety record.
37:47ENWorking Backwards from AGI: Magic's Five-Million-Token BetPresenta: Sarah Guo, Elad GilEric Steinberger wants a coding colleague you trust like a teammate — and a world that is still a good place thirty years after AGI.
2:15:39ENRoman Yampolskiy Puts Superintelligent Ruin at 99.99 PercentInvitado: Roman Yampolskiy · Presenta: Lex FridmanThe AI safety researcher tells Lex Fridman that controlling AGI is as impossible as a perpetual motion machine, and that tests, open source, and regulation cannot close the gap.
31:24ENSora's Leads: A Minute of HD Video Is Just the GPT-1 of Video ModelsPresenta: Sarah Guo, Elad GilAditya Ramesh, Tim Brooks, and Bill Peebles tell No Priors why text-to-video sits on the path to AGI, why they started from scratch instead of extending an image generator, and why they still have no product date.
3:07:27ENFive Billion Dead, and One Person Has Six MinutesInvitado: Annie Jacobsen · Presenta: Lex FridmanAnnie Jacobsen walks Lex Fridman from a second-by-second nuclear exchange to CIA secrecy, Area 51, and why she still wants the word “could” kept in the sentence.
1:55:10ENSam Altman Expects the Road to AGI to Be a Power StruggleInvitado: Sam Altman · Presenta: Lex FridmanOn a Friday afternoon in November 2023, OpenAI's board fired its CEO. Four and a half days later he was back, still refusing super-voting control.
19:10ENThe World's Only Capped-Profit CompanyPresenta: Sarah Guo, Elad GilNo Priors looks back at 2023 through eight conversations on money, intelligence, jobs, and who should put the guardrails on a model.
2:53:09ENFear is the civilization killer: Guillaume Verdon on e/acc, thermodynamics, and being unmaskedInvitado: Guillaume Verdon · Presenta: Lex FridmanThe physicist behind BasedBeffJezos tells Lex Fridman why out-of-equilibrium thermodynamics, anonymity, and a meme movement are his answer to AI deceleration.
32:57ENA 7-billion-parameter model on a MacBook: Mistral's CEO reruns the cost of AIPresenta: Sarah Guo, Elad GilArthur Mensch tells No Priors why Chinchilla made small models valuable, why open-sourcing Mistral 7B is not a bioweapon risk, and why guardrails belong on the application.
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