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3:18:09EN
Lex Fridman· 30 nov 2025Pódcast · 2 vocesA Thing Is Alive When Its Goals Outrun Its PartsInvitado: Michael Levin · Presenta: Lex FridmanTufts biologist Michael Levin tells Lex Fridman that intelligence is a spectrum of persuadability, that even a bubble sort hosts unexpected goals, and that the brain is a thin client to a space physics does not own.
49:27EN
No Priors: AI, Machine Learning, Tech, & Startups· 3 jul 2025Pódcast · 2 vocesFrom 0.1% to 20%: Chai-2 Turns Antibody Design Into Prompt EngineeringPresenta: Sarah Guo, Elad GilChai Discovery co-founders Joshua Meier and Jack Dent tell Sarah Guo how a generative model now designs antibodies that bind on the first 24-well plate.
37:01ENNo Priors: AI, Machine Learning, Tech, & Startups· 28 sept 2023Pódcast · 2 vocesDNA Is Code, but You Compile It with a PipettePresenta: Sarah Guo, Elad GilGinkgo Bioworks CEO Jason Kelly tells No Priors why cells are worth the magic, why biology has no AWS, and why a pandemic should look like cybersecurity.
2:18:25ENLex Fridman· 1 sept 2023Pódcast · 2 vocesGrow Everything: Neri Oxman on Giving Nature a VoteInvitado: Neri Oxman · Presenta: Lex FridmanThe designer-scientist who left MIT to build OXMAN talks silkworm pavilions, bees in space, and why the end of human agency might be the start of nature's.
35:24ENNo Priors: AI, Machine Learning, Tech, & Startups· 24 ago 2023Pódcast · 2 vocesThe Author of Attention Is All You Need Now Compiles mRNA Like BytecodePresenta: Sarah Guo, Elad GilJakob Uszkoreit on why Transformers won, why models spend compute on the wrong things, and why drug discovery has to become generation rather than screening.
2:40:18ENLex Fridman· 29 dic 2022Pódcast · 2 vocesEvery Living Cell Runs the Same Translation MachineInvitado: Betül Kaçar · Presenta: Lex FridmanAstrobiologist Betül Kaçar tells Lex Fridman how the tree of life is drawn backward, why nitrogen was fixed only once, and why the genetic code is an alphabet with room for typos.
3:00:21ENLex Fridman· 1 oct 2022Pódcast · 2 vocesCut Off a Planarian's Head. The New Brain Still RemembersInvitado: Michael Levin · Presenta: Lex FridmanMichael Levin argues that DNA only builds hardware, bioelectric networks store body plans, and frog skin cells can become robots that evolution never designed.
3:43:01ENLex Fridman· 7 sept 2022Pódcast · 2 vocesPut Hydrogen and CO2 in a Tube. Thermodynamics Wants Cells. Nothing Happens.Invitado: Nick Lane · Presenta: Lex FridmanBiochemist Nick Lane talks Lex Fridman through hydrothermal vents, mitochondria, sex, consciousness, and why bacteria should be common while civilizations are not.
2:10:39ENLex Fridman· 1 jul 2022Pódcast · 2 vocesDemis Hassabis: Solve Intelligence, Then Solve Everything ElseInvitado: Demis Hassabis · Presenta: Lex FridmanThe DeepMind CEO tells Lex Fridman why the Turing Test is the wrong exam, how AlphaFold rewrote biology, and why the quiet radio sky suggests we are probably alone.
2:55:05ENLex Fridman· 8 may 2022Pódcast · 2 vocesExtinction awareness is the human trait Mason wants to carry to the starsInvitado: Chris Mason · Presenta: Lex FridmanCornell geneticist Chris Mason on why seeing our own end creates a duty to engineer life for other worlds — and what a 500-year plan would actually require.
1:26:53ENLex Fridman· 5 nov 2021Pódcast · 2 vocesFrancis Collins Cannot Exclude a Lab LeakInvitado: Francis Collins · Presenta: Lex FridmanThe outgoing NIH director talks with Lex Fridman about COVID origins, gain-of-function research, Anthony Fauci, vaccines, and why scientific certainty is the wrong pose.
2:59:12ENLex Fridman· 20 jun 2021Pódcast · 2 vocesNature Never Dealt This CardInvitado: Rob Reid · Presenta: Lex FridmanIn 2011 two labs independently engineered H5N1 so it could travel through the air between mammals — work Rob Reid tells Lex Fridman should never have been done, and still has not been stopped.
1:41:34ENLex Fridman· 6 jun 2021Pódcast · 2 vocesAging Is a Scratched Disc. David Sinclair Thinks the Body Kept a BackupInvitado: David Sinclair · Presenta: Lex FridmanThe Harvard geneticist tells Lex Fridman why aging is information loss, how three genes gave a blind mouse its sight back, and why skipping meals may beat the perfect diet.
2:17:42ENLex Fridman· 11 ene 2021Pódcast · 2 vocesThe building block of life is a bead on a string, not the whole proteinInvitado: Dmitry Korkin · Presenta: Lex FridmanDmitry Korkin tells Lex Fridman why protein domains, a triangular spike, and a conservative viral shell matter more than the AlphaFold headline, and why a Nobel laureate once answered a midnight forum post.
2:14:55ENLex Fridman· 30 nov 2020Pódcast · 2 vocesHis Wife Calls Him the RadioInvitado: Manolis Kellis · Presenta: Lex FridmanMIT computational biologist Manolis Kellis spends the first forty minutes of his fourth Lex Fridman conversation on the songs that formed him, then turns to 42, dinosaurs, and why hunting for meaning matters more than finding it.
2:39:45ENLex Fridman· 25 oct 2020Pódcast · 2 vocesThe obesity gene was never the obesity geneInvitado: Manolis Kellis · Presenta: Lex FridmanManolis Kellis tells Lex Fridman how one nucleotide a million bases from FTO rewrote obesity biology, and why human genetics is now driving the study of disease.
2:10:53ENLex Fridman· 12 sept 2020Pódcast · 2 vocesAll Your DNA Would Reach Jupiter a Hundred Times OverInvitado: Manolis Kellis · Presenta: Lex FridmanManolis Kellis talks Lex Fridman through the epigenome, Neanderthals, Europa, midlife, and why "are you happy?" is the wrong question.
2:29:24ENLex Fridman· 31 jul 2020Pódcast · 2 vocesWe Are the Descendants of the First Digital ComputerInvitado: Manolis Kellis · Presenta: Lex FridmanMIT computational biologist Manolis Kellis tells Lex Fridman why life is digital, why any two humans are 99.9 percent identical, and what evolutionary signatures reveal inside SARS-CoV-2.
1:02:14ENLex Fridman· 30 jun 2020Pódcast · 2 vocesThe 28-year wait: Robert Langer on rejection, polymers, and a thousand studentsInvitado: Robert Langer · Presenta: Lex FridmanThe MIT bioengineer talks with Lex Fridman about drug delivery, tissue engineering, patents, and the long path from a Folkman hypothesis to Avastin.
1:12:03ENLex Fridman· 5 may 2020Pódcast · 2 vocesMice Don't Get Alzheimer's: Daphne Koller on Disease in a DishInvitado: Daphne Koller · Presenta: Lex FridmanThe Coursera co-founder and insitro CEO on why most diseases are not one disease, how to turn cells into data, and why overconfident neural nets can kill.
2:09:02ENLex Fridman· 22 abr 2020Pódcast · 2 vocesA Hundred-Nanometer Machine That Is Not Quite AliveInvitado: Dmitry Korkin · Presenta: Lex FridmanDmitry Korkin walks through the structural genomics of SARS-CoV-2, from spike-ACE2 docking to drug-binding sites, vaccines, and cruise-ship simulations, recorded in the first spring of the pandemic.
57:42ENLex Fridman· 12 ago 2019Pódcast · 2 vocesA Brain Organoid Is Not a BrainInvitado: Paola Arlotta · Presenta: Lex FridmanHarvard developmental biologist Paola Arlotta on how the cerebral cortex is built, why timing and mechanical force are part of the code, and why a dish of stem cells is only a window onto that process.
56:20ENNo Priors: AI, Machine Learning, Tech, & StartupsPódcast · 2 vocesBiohub's Bet: Building Open AI World Models of Biology From Proteins Up to CellsPresenta: Sarah Guo, Elad GilMark Zuckerberg, Priscilla Chan and Alex Rives explain why Biohub pairs a frontier AI lab with frontier wet-lab biology, and why it releases tools like ESMFold2 as open source.