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16:41ENAlphaFold 2 and the Protein-Folding Breakthrough: Why Lex Fridman Calls It a Landmark for AI and BiologyPresenta: Lex FridmanA quick explainer on DeepMind's CASP14 result, how protein folding works, how AlphaFold 1 and 2 likely differ, and what the advance could unlock.
23:54ENBeyond GPT-7: The Customization Toolkit, Meta's Open Source Bet and the Return of Consumer AIPresenta: Sarah Guo, Elad GilIn a host-only episode, the No Priors hosts map the six levers for 10x to 100x better AI, explain fine-tuning, RAG and AI feedback, and ask why consumer social is suddenly interesting again.
1:19:52ENFrom Pixels to Steering Wheels: Convolutional Networks and End-to-End DrivingPresenta: Lex FridmanLex Fridman's MIT 6.S094 lecture explains how convolutional neural networks work, where deep learning helps a self-driving car, and how to train a network to steer from video.
57:21ENGemini 2.0 Flash Goes to Production: Pricing, Model Lineup and What Developers Should Build NextPresenta: Nathan LabenzGoogle DeepMind's Logan Kilpatrick walks through launch-day Gemini 2.0 releases, rate limits, model naming, and where he sees startup opportunities.
1:27:30ENFrom NAND Gates to Self-Driving Traffic: Deep Reinforcement Learning in One LecturePresenta: Lex FridmanLex Fridman's second MIT 6.S094 lecture walks from the humble perceptron to deep Q-learning and the browser-based DeepTraffic competition.
1:05:15ENTaming the Long Tail: How Waymo Builds a Self-Driving FactoryPresenta: Lex FridmanWaymo principal scientist Drago Anguelov explains how machine learning infrastructure, hybrid design and smart simulated agents tackle the rare events of autonomous driving.
1:27:15ENPolicy Gradients vs. Q-Learning: John Schulman's Field Guide to Deep Reinforcement LearningPresenta: Lex FridmanOpenAI's John Schulman walks through the core methods of deep RL, from the score function estimator to TRPO and DQN, and says when each one is worth using.
1:19:21ENVapnik's Case for Learning by Predicates, Not Just by More DataPresenta: Lex FridmanIn an MIT lecture, Vladimir Vapnik argues that complete statistical learning needs two mechanisms, data and invariants, and that choosing smart predicates is where intelligence lives.
1:03:25ENTheano in an Hour: Symbolic Graphs, Automatic Gradients and a Compiler That Rewrites Your MathPresenta: Lex FridmanPascal Lamblin of MILA walks through how Theano builds, differentiates, optimizes and runs computation graphs, then trains logistic regression, a convnet and an LSTM.
1:08:06ENDeep Learning in One Lecture: From Perceptrons to AutoML and the Limits of LearningInvitado: Deep Learning Basics · Presenta: Lex FridmanLex Fridman's opening lecture for MIT's 6.S094 course surveys why deep learning took off, how neural networks learn, and where the technique still falls short.
57:25ENFrom RAG to Reasoning: Why the Future of AI Is a System, Not a ModelPresenta: Jacob EffronDouwe Kiela explains what OpenAI's o1 reveals about test-time compute, why enterprise AI must be specialized, and where post-training and evaluations are heading.
13:58ENDeep Reinforcement Learning, Explained by the Researcher Behind AlphaGoPresenta: Lex FridmanDavid Silver of DeepMind walks through what reinforcement learning is, how its building blocks fit together, and why deep neural networks keep surprising even the experts.
57:55ENFrom Q-Tables to AlphaGo Zero: A Self-Driving Car Lecture on Deep Reinforcement LearningPresenta: Lex FridmanLex Fridman's MIT 6.S094 lecture walks from the AI pipeline and Q-learning to deep Q-networks, AlphaGo Zero and the DeepTraffic competition.
1:13:22ENThe Second 90%: What It Really Takes to Put Deep Learning on a Driverless CarPresenta: Lex FridmanWaymo's Sacha Arnoud walks MIT students through Waymo's history, its perception stack, and the industrial-scale labeling, compute and testing behind it.
57:15ENInside Torch and Autograd: How Deep Learning Libraries Compute GradientsPresenta: Lex FridmanAlex Wiltschko of Twitter walks through Lua Torch, then explains automatic differentiation and what separates modern deep learning frameworks.
1:12:12ENModels Are Grown, Not Built: What Anthropic's Interpretability Research Sees Inside ClaudePresenta: Lenny RachitskyAnthropic researcher Emmanuel Ameisen explains how studying a language model's intermediate computations reveals concepts, plans and surprising quirks, and why that matters for alignment.
1:20:58ENFrom Bag of Words to Attention: Quoc Le Teaches Sequence-to-Sequence Learning Through Email RepliesPresenta: Lex FridmanA Deep Learning School talk that builds sequence-to-sequence models step by step around one running example, automatic email reply, and then surveys memory and operation-augmented networks.
1:19:48ENBigger Models, Cleaner Splits and Human Baselines: Andrew Ng's Practical Recipe for Applied Deep LearningPresenta: Lex FridmanIn a 2016 Deep Learning School talk, Andrew Ng distills lessons from leading Baidu's AI team into a workflow for diagnosing models, handling data and building a career.
1:02:06ENLearning TensorFlow Hands-On: From a Mystery Line to Handwritten DigitsPresenta: Lex FridmanGoogle Brain's Sherry Moore walks a Deep Learning School audience through how TensorFlow works and two core labs, linear regression and MNIST digit recognition.
20:36ENWhy Simple Theories Win: Marcus Hutter on Occam's Razor, Compression and Kolmogorov ComplexityPresenta: Lex FridmanDeepMind researcher Marcus Hutter explains Solomonoff induction, why compression equals understanding, and how a simple universe can still look rich.
10:34ENWhy Deep Learning Needs Rules: Chollet on Interpolation, Abstraction and Hybrid AIInvitado: François Chollet · Presenta: Lex FridmanFrançois Chollet explains why neural networks only interpolate between points they have seen, and why the best AI systems pair them with symbolic rules.
1:19:34ENFei-Fei Li on ImageNet, World Models and Why Everyone Has a Role in AIPresenta: Lenny RachitskyThe scientist often called the godmother of AI traces how big data sparked deep learning, explains why spatial intelligence is the next frontier, and shows what World Labs' first product, Marble, can do.
53:13ENHow Machines Learn to See: From Pixel Differences to Convolutions, ResNets and Scene SegmentationPresenta: Lex FridmanLex Fridman's MIT 6.S094 lecture walks from the basics of image classification through landmark network architectures to pixel-level segmentation, optical flow and the SegFuse competition.
34:33ENTeaching Cars to Watch the Driver: Deep Learning for Semi-Autonomous VehiclesPresenta: Lex FridmanLex Fridman's MIT 6.S094 lecture on using driver-facing cameras and neural networks to understand body pose, gaze, emotion and cognitive load.
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