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1:04:26ENAt 100,000 Accelerators, Something Fails Every HourGoogle AI infrastructure chief Amin Vahdat tells Sequoia's Sonya Huang why FLOPS is a vanity metric, why the TPU line split in two, and why he would rather wait on a utility than build his own gigawatt.
2:40:38ENAI’s Memory Wall and the Work of AI EngineeringInvitado: Thomas Sohmers, Shawn Wang · Presenta: Nathan LabenzThomas Sohmers discusses inference hardware; Shawn Wang examines agent workflows and evaluation.
1:19:35ENAndrew Huberman on Sleep, Neurotechnology and the Future of Brain InterfacesInvitado: Andrew Huberman · Presenta: Patrick O'ShaughnessyA conversation with Patrick O’Shaughnessy about evidence and possibilities.
29:39ENThe State of Software Engineering in 2026: What Changed and What Did NotGergely Orosz reports from AI labs, startups and large technology companies.
56:31ENPost-Training Wins Inference: Why Owning the Weights Beats Betting on One LabPresenta: Jacob EffronApplied Compute CEO Yash Patil argues that control, private evals, and post-training on the biggest workloads matter more than fearing that frontier labs will turn malicious.
35:41ENChatGPT Sites for Work, Music and GamesInvitado: Kath Korevec · Presenta: Claire VoOpenAI’s Kath Korevec demonstrates connected sites and personal projects.
49:48ENWho Pays for Consumer AI, and What Could Bring It to Everyone Else?Invitado: Olivia Moore, Josh Elman · Presenta: Elena Burgera16z’s consumer AI report finds concentrated spending among power users and asks what products and business models could broaden adoption.
1:10:29ENHow Anthropic Used Claude to Improve App PerformanceTheo Browne · Ping LabsTheo Browne examines a two-week performance sprint, its measurement tools, human review and the tradeoffs behind faster interfaces.
1:11:14ENVenky Ganesan on AI Venture Investing, Ownership and the Cost of Missing OutInvitado: Venky Ganesan · Presenta: Harry StebbingsMenlo Ventures' partner discusses seed bets, concentrated follow-ons, market cycles, investor liquidity and the discipline needed when AI valuations accelerate.
0:26ENA DeepSeek V4.1 Flash Portrait Painted Through a Browser ToolMatthew Berman · Forward FutureMatthew Berman compares a reference headshot with a stylized result made using a Paint-like website.
48:20ENWhy Specialized AI Could Challenge the All-Purpose ModelInvitado: Alex Atallah, Amjad Masad · Presenta: Erik TorenbergOpenRouter and Replit leaders discuss model choice, agent coordination and safety.
1:05:01ENChase Lochmiller on AI Data Centers, Energy and GPU EconomicsInvitado: Chase Lochmiller · Presenta: Harry StebbingsCrusoe’s CEO discusses the constraints on AI infrastructure, the economics of GPU capacity and his company’s approach to energy and managed inference.
1:30:54ENHumanoids Outran Usain Bolt. DeepMind Still Scores Robotics as GPT-2Presenta: Nathan LabenzGoogle DeepMind's Gemini Robotics lead on why sprinting is easy, frying an egg is hard, and one brain should drive any body.
1:11ENChamath Palihapitiya on Three AI Governance PracticesA short proposal for tracing AI activity, mapping policies to risk and keeping audit evidence.
1:20:35ENBeyond GPUs: Optical, Neuromorphic and Biological ComputingFrançois Chaubard, Ilker Oguz, Alok Vasudev, Sean Cole · Y CombinatorYC Paper Club explores alternative hardware and the algorithms that might use it.
1:22:29ENAll-In: A White House AI Accord, Economic Data and Midterm PredictionsPresenta: Jason Calacanis, Chamath Palihapitiya, David Sacks, David FriedbergThe hosts discuss voluntary AI governance, cyber defense, economic pressures and differing election forecasts.
51:08ENPersonal AI Agents: Convenience, Oversight and New FrictionInvitado: Mike Isaac, Erin Griffith, Eli Tan · Presenta: Max ReadHard Fork discusses hands-on use, security and the limits of self-regulation.
13:23ENA Week Coding with Local AI: Memory, Context and SpeedAdrian TwarogAdrian Twarog tests local models on a sponsored mini PC.
35:39ENCompute Scaled a Millionfold. Bandwidth Only 40x. Fractile Wants to Fix That RatioPresenta: Sarah Guo, Elad GilIn the summer of 2022, Walter Goodwin founded Fractile in London to build very fast inference chips for the world's largest models.
59:13ENAI Agents and the Work Behind Enterprise ProcurementInvitado: Vladimir Keil · Presenta: Seema Amble, Elena BurgerLio’s Vladimir Keil discusses context, negotiation and multi-agent workflows with a16z.
1:06:36ENTheo’s Guide to Running Coding Agents in ParallelTheo Browne · T3Theo explains his approach to subscription usage, agent delegation, review and remote machines, while acknowledging that parts of his setup may violate provider rules.
45:06ENBarrett Lyon on Rebuilding Internet Privacy and InfrastructureInvitado: Barrett Lyon · Presenta: Joel de la GarzaThe DoxxNet founder discusses mesh networking, tracking, infrastructure operations and his path from DDoS defense to internet art.
38:28ENAI Agent Security and the Challenge of Recursive Self-ImprovementAI Explained examines reported containment failures, model evaluation and the pressure to accelerate AI research.
1:10:10ENHow Voice Agents Learn the Rhythm of ConversationInvitado: Tsung-Hsien (Shawn) Wen · Presenta: Tim ScarfePolyAI’s Shawn Wen discusses turn-taking, noisy audio and the work of checking AI output.
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