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1:22:49ENBryan Cantrill: Why Software and Hardware Must Be Designed TogetherBryan Cantrill · Oxide Computer CompanyFrom a stubborn CPU reset to disappearing drives, Oxide’s cofounder makes the case for designing and debugging computing systems across the hardware–software boundary.
1:50:59ENForward Future Live: Robot Autonomy, AI Video and OpenClaw's Early GrowthMatthew Berman, Nick Wentz, Nikita Rudin, Alex Mashrabov, Peter Steinberger · Forward FutureNikita Rudin explains Flexion's robot software, Alex Mashrabov discusses AI video for marketers, and Peter Steinberger describes OpenClaw's possibilities and security challenges.
4:25:13ENThe Architecture Barely Changed. Data, Cost, and Open Weights Did.Presenta: Lex FridmanNathan Lambert and Sebastian Raschka walk Lex Fridman through a year in which training methods and datasets moved more than model design, and 2026 looks like a fight over inference cost, agents, and who owns truly open models.
30:47ENEmbryos Survive 30 Years Frozen. Until Wants Organs to Stop Racing Private JetsPresenta: Sarah Guo, Elad GilLaura Deming on reversible cryopreservation: pause an organ—and someday a patient—so a few months no longer decide who lives long enough for the next therapy.
1:03:00ENA Model That Solves New Math Problems Every Week Still Isn't AGIPresenta: Jacob EffronFormer OpenAI research VP Jerry Tworek on why scaling still works, why models go hopeless when they fail, and why he left to chase continual learning.
1:18:04ENBrex, AI Inference Costs and the IPO Market: A 20VC RoundtableInvitado: Jason Lemkin, Rory O’Driscoll · Presenta: Harry StebbingsHarry Stebbings, Jason Lemkin and Rory O’Driscoll debate reported deals, AI economics and public-market exits. Their valuations, financial figures and predictions are estimates or reported claims, not independently verified results.
1:39:17ENAI Already Beats the Median Lawyer. Top Firms Bought the Tools and Left Them UnusedPresenta: Nathan LabenzKevin Frazier and Alan Rozenshtein walk through how frontier models are changing legal practice, why billable hours stall adoption, and which new rights and government limits they want next.
48:03ENCoding Will Be Solved. The Bottleneck Is Saying What You WantWarp founder Zach Lloyd tells Sequoia's Sonya Huang why a rebuilt terminal became the lucky form factor for coding agents, and why he stopped subsidizing tokens.
1:06:37ENLegora CEO Max Junestrand on Legal AI, Growth and CompetitionInvitado: Max Junestrand · Presenta: Harry StebbingsThe founder discusses enterprise adoption, model choices and pricing, as well as his predictions for legal work and the structure of the market.
2:12:31ENMost Caffeine users have no idea they are on a blockchainPresenta: Nathan LabenzDFINITY's Dominic Williams tells Nathan Labenz why a tamper-proof, unstoppable cloud is the right backend for AI that writes software from a chat box.
2:25:10ENFine-Tuning Isn't Dead — But It Turned a Helpful Model EvilPresenta: Nathan LabenzNathan Labenz on why prompting replaced fine-tuning for most work, what emergent misalignment actually showed, and how he is thinking about jobs, UBI, and AGI.
1:23:12ENVenture Returns, OpenAI Litigation and the Economics of AI GrowthInvitado: Jason Lemkin, Rory O’Driscoll · Presenta: Harry StebbingsHarry Stebbings, Jason Lemkin and Rory O’Driscoll debate public software prices, research talent, AI advertising and late-stage venture valuations.
39:47ENThe Context at Step 14 Isn't in the CodeLangChain cofounder Harrison Chase on why long-horizon agents finally work—and why traces, harnesses, and first-draft workflows matter more than scaffolding.
1:13:24ENWinston Weinberg on Building Harvey, Enterprise AI and the Art of DealsInvitado: Winston Weinberg · Presenta: Harry StebbingsHarvey’s co-founder explains how he thinks about founder focus, enterprise adoption, hiring and negotiating while legal AI changes.
2:29:42ENTwelve hooks and thirty files: Daniel Miessler’s personal OS on Claude CodePresenta: Nathan LabenzThe PAI framework treats scaffolding, not the model, as the product — a goal-centered agent stack that Miessler thinks will decide both knowledge-work automation and the next cybersecurity race.
1:52:02ENForward Future Live: AI Engineering, Enterprise Agents, Mathematics and AdoptionMatthew Berman, Nick Wentz, Austen Allred, Aaron Levie, Tudor Achim, Ara Kharazian · Forward FutureAusten Allred, Aaron Levie, Tudor Achim and Ara Kharazian join Matthew Berman and Nick Wentz to discuss how AI is changing work and how to measure its use.
1:30:52ENAI Financing, Venture Scale and the Risks Behind Growth ValuationsInvitado: Jason Lemkin, Rory O’Driscoll · Presenta: Harry StebbingsHarry Stebbings, Jason Lemkin and Rory O’Driscoll debate model-provider competition, large venture funds and a proposed wealth tax.
1:40:51ENReasoning Models Just Made the Other 80–90% of Enterprise Data UsablePresenta: Nathan LabenzSnowflake VP of AI Baris Gultekin on text-to-SQL, RAG, agent design, and why inference has to run next to governed data.
37:00ENThe AlphaChip Team That Laid Out Four TPUs Now Wants Every Company to Be DesignlessAnna Goldie and Azalia Mirhoseini tell Sequoia how an RL floorplanner survived TPU-team anger, learned to draw donut-shaped macros, and became a bet that AI will design chips that then feed AI.
3:06:19ENThey Call Themselves Brothers: First Contact in the AmazonInvitado: Paul Rosolie · Presenta: Lex FridmanPaul Rosolie tells Lex Fridman about a historic encounter with an uncontacted Amazon clan, a narco war on his river, and the race to buy the last wild corridor.
1:15:19ENAlex Rampell on Venture Scale, Founder Judgment and Durable AI BusinessesInvitado: Alex Rampell · Presenta: Harry StebbingsThe Andreessen Horowitz investor explains how he weighs ownership, founder motivation and customer retention as venture funds and AI markets grow.
2:05:47ENAI Agents, Open Models and Inference: Forward Future Live with Reflection AI, Microsoft and CerebrasMatthew Berman, Nick Wentz, Ioannis Antonoglou, Sam Schillace, Andrew Feldman · Forward FutureIoannis Antonoglou, Sam Schillace and Andrew Feldman discuss reinforcement learning, software workflows and AI infrastructure with Matthew Berman and Nick Wentz.
1:54:30ENFrom One in Ten Cancer Cells to One in a MillionPresenta: Nathan LabenzNathan Labenz's solo AMA updates his son's lymphoma treatment, calls Claude Opus 4.5 software AGI, and ranks the live players of early 2026.
38:28ENOscar Hoglund on Value Chains, AI Tools, and Building Epidemic Sound Without Losing Your LifeInvitado: Oscar Hoglund · Presenta: Marina MogilkoEpidemic Sound’s cofounder joins Marina Mogilko to explain creative contrast, the move from feature to platform, and the discipline behind sustainable company building.
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