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41:40ENEvery 10 Milliseconds Cost Copilot 1% of CompletionsPresenta: Sarah Guo, Elad GilGitHub Copilot's chief architect, Alex Graveley, walks through how a leftover code model with a sub-10% test pass rate became a product developers would not quit — and what he is building next at Minion AI.
2:23:56ENGPT-4 is a very early AI. ChatGPT is the line in the history booksInvitado: Sam Altman · Presenta: Lex FridmanSix days after GPT-4 shipped, Sam Altman tells Lex Fridman why usability beat raw scale, why alignment and capability are not opposite vectors, and why OpenAI is trying to deploy while the stakes are still low.
39:10ENNever Cite More Than Five Links: Perplexity's Bet on Answer EnginesPresenta: Sarah Guo, Elad GilFounded in August 2022, Perplexity was barely seven months old when its CEO and CTO sat down with No Priors to explain how an answer engine takes on Google.
35:36ENFeatured snippets stalled at 7%. A Google veteran used language models to hit 70%Presenta: Sarah Guo, Elad GilNeeva founder Sridhar Ramaswamy tells No Priors why answers always beat links, why privacy never sold the switch, and why most queries do not need the biggest model.
46:57EN95% of Drug Programs Fail. Daphne Koller Is Betting Machine Learning on the First DecisionPresenta: Sarah Guo, Elad GilA new medicine still takes more than a decade and well over a billion dollars — and Insitro's founder argues the expensive failures start with the wrong target, indication, or patient.
48:52ENUsers Wanted a Better Brush. Runway Built One-Click GreenscreenPresenta: Sarah Guo, Elad GilRunway CEO Cristobal Valenzuela on why a model is not a product, why filmmakers hacked a four-frame-per-second tool, and why 80 percent is enough when nobody dies.
2:17:46ENOne Great Video Beats a Hundred Mediocre OnesInvitado: MrBeast · Presenta: Lex FridmanMrBeast tells Lex Fridman why evergreen hits outlast volume, why YouTube comments are a disgrace, and why an AI clone of himself would drain every video of meaning.
2:29:24ENA Hundred Users Signed Up and Never Came BackInvitado: Brian Armstrong · Presenta: Lex FridmanCoinbase CEO Brian Armstrong on the buy button that found product-market fit, why he wants customers to leave his platform, and a company that refuses to be a political square.
2:46:26ENApple Was a $5 Billion Company in Debt When Tony Fadell Built the iPodInvitado: Tony Fadell · Presenta: Lex FridmanLex Fridman talks with Tony Fadell, co-creator of the iPod, iPhone, and Nest Thermostat, about the decisions, fights, and luck behind those products.
1:09:10ENThe Same Snapdragon That Flies on Mars Powers a Galaxy PhoneInvitado: Cristiano Amon · Presenta: Lex FridmanQualcomm CEO Cristiano Amon talks with Lex Fridman about 5G, Snapdragon, cars, the chip shortage, and how to map the border of your own competence.
2:00:13ENHalf of America Dislikes Him. Zuckerberg Still Wants Presence, Not ScreensInvitado: Mark Zuckerberg · Presenta: Lex FridmanLex Fridman sits with Meta CEO Mark Zuckerberg on virtual presence, Instagram's teen research, free speech, and why every content decision costs the company half the country.
2:44:38ENPosting a photo of this moment was not a product category yetInvitado: Kevin Systrom · Presenta: Lex FridmanKevin Systrom tells Lex Fridman how Instagram began as a failed check-in app, hid a slow upload behind a caption screen, and later sold a thirteen-person company to Facebook for a billion dollars.
3:14:14ENFour Joints, Eighty Thousand Pounds: Boris Sofman on Cozmo and WaymoInvitado: Boris Sofman · Presenta: Lex FridmanAnki's co-founder on saturating a few channels of expression, why a beloved robot company still died, and how the same constraint mindset now runs Waymo's trucks.
1:28:46ENThe Speech Company That Gets Paid to Label Its Own Training DataInvitado: Dan Kokotov · Presenta: Lex FridmanRev VP of engineering Dan Kokotov tells Lex Fridman why a $1.25-a-minute human transcript, a 14% machine word-error rate, and a two-sided freelancer market are the same flywheel.
2:23:10ENBuilding a Driver, Not a Copilot: Waymo CTO Dmitri Dolgov on Fully Driverless CarsInvitado: Dmitri Dolgov · Presenta: Lex FridmanFrom a 3 a.m. parking-lot planner at Stanford to a public robotaxi in Phoenix, Dolgov tells Lex Fridman why driver assist and a real driver are different products.
37:38ENThe Best-Selling Vacuum in America Is a RobotInvitado: Colin Angle · Presenta: Lex FridmaniRobot CEO Colin Angle on why most robotics companies die, why a Roomba is costed by weight, and why printing privacy promises on the box would hurt sales.
57:44ENKevin Scott: Treat AI Like a Hash Table, and Measure Platforms by What Others EarnInvitado: Kevin Scott · Presenta: Lex FridmanMicrosoft's CTO talks radical markets, data dignity, Dunbar's number, and why a platform fails if only a handful of companies decide what AI is for.
1:47:04ENGustav Söderström on Why Spotify Could Only Be Born in SwedenInvitado: Gustav Soderstrom · Presenta: Lex FridmanLex Fridman talks with Spotify’s chief R&D officer about three-minute songs, 250-millisecond playback, playlist luck, and herding record labels.
55:24ENKyle Vogt Built the Highway Kit, Then Scrapped It Before Selling a Single OneInvitado: Kyle Vogt · Presenta: Lex FridmanThe Cruise president and CTO tells Lex Fridman why a BattleBots kid from Kansas walked away from a working product, partnered with GM, and is spending 2019 grinding from prototype to production.
1:01:00ENControl Over Attention: How Substack Builds Product for Writers and ReadersInvitado: Sachin Monga · Presenta: Lenny RachitskySubstack's head of product, Sachin Monga, explains the principle behind the company's roadmap, the story of the Recommendations feature, and what he thinks the next era of writing on the internet looks like.
1:27:13ENFour Levels of Product-Market Fit: First Round's Playbook for B2B FoundersInvitado: Todd Jackson · Presenta: Lenny RachitskyTodd Jackson of First Round Capital walks through a staged framework for finding product-market fit, the benchmarks for each stage, and the four Ps you can change when you're stuck.
1:21:35ENLook Outside the Building: Shaun Clowes on Why Most PMs Fall Short and How AI Changes the JobInvitado: Shaun Clowes · Presenta: Lenny RachitskyConfluent's chief product officer explains how to become a far better product manager, why data matters more than models, and what AI will and won't do to SaaS.
1:35:11ENDon't Chase the Fake Rabbit: A Meta Product Leader's Guide to a 60-Year PM CareerInvitado: Nikhyl Singhal · Presenta: Lenny RachitskyNikhyl Singhal walks through early, mid and late career for product managers, from avoiding ex-growth companies to finding a North Star for "act three".
1:00:51ENInflict Pain, But Do It With a Smile: Julia Schottenstein on dbt's Rise and the Art of Getting AcquiredInvitado: Julia Schottenstein · Presenta: Lenny RachitskyA former NEA investor turned dbt Cloud product leader explains why dbt won, how to approach M&A and pricing, and how venture habits make her a better PM.
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