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1:26:53EN
Lex Fridman· 5 nov 2021Pódcast · 2 vocesFrancis Collins Cannot Exclude a Lab LeakInvitado: Francis Collins · Presenta: Lex FridmanThe outgoing NIH director talks with Lex Fridman about COVID origins, gain-of-function research, Anthony Fauci, vaccines, and why scientific certainty is the wrong pose.
2:59:12ENLex Fridman· 20 jun 2021Pódcast · 2 vocesNature Never Dealt This CardInvitado: Rob Reid · Presenta: Lex FridmanIn 2011 two labs independently engineered H5N1 so it could travel through the air between mammals — work Rob Reid tells Lex Fridman should never have been done, and still has not been stopped.
1:41:34ENLex Fridman· 6 jun 2021Pódcast · 2 vocesAging Is a Scratched Disc. David Sinclair Thinks the Body Kept a BackupInvitado: David Sinclair · Presenta: Lex FridmanThe Harvard geneticist tells Lex Fridman why aging is information loss, how three genes gave a blind mouse its sight back, and why skipping meals may beat the perfect diet.
2:17:42ENLex Fridman· 11 ene 2021Pódcast · 2 vocesThe building block of life is a bead on a string, not the whole proteinInvitado: Dmitry Korkin · Presenta: Lex FridmanDmitry Korkin tells Lex Fridman why protein domains, a triangular spike, and a conservative viral shell matter more than the AlphaFold headline, and why a Nobel laureate once answered a midnight forum post.
2:14:55ENLex Fridman· 30 nov 2020Pódcast · 2 vocesHis Wife Calls Him the RadioInvitado: Manolis Kellis · Presenta: Lex FridmanMIT computational biologist Manolis Kellis spends the first forty minutes of his fourth Lex Fridman conversation on the songs that formed him, then turns to 42, dinosaurs, and why hunting for meaning matters more than finding it.
2:39:45ENLex Fridman· 25 oct 2020Pódcast · 2 vocesThe obesity gene was never the obesity geneInvitado: Manolis Kellis · Presenta: Lex FridmanManolis Kellis tells Lex Fridman how one nucleotide a million bases from FTO rewrote obesity biology, and why human genetics is now driving the study of disease.
2:10:53ENLex Fridman· 12 sept 2020Pódcast · 2 vocesAll Your DNA Would Reach Jupiter a Hundred Times OverInvitado: Manolis Kellis · Presenta: Lex FridmanManolis Kellis talks Lex Fridman through the epigenome, Neanderthals, Europa, midlife, and why "are you happy?" is the wrong question.
2:29:24ENLex Fridman· 31 jul 2020Pódcast · 2 vocesWe Are the Descendants of the First Digital ComputerInvitado: Manolis Kellis · Presenta: Lex FridmanMIT computational biologist Manolis Kellis tells Lex Fridman why life is digital, why any two humans are 99.9 percent identical, and what evolutionary signatures reveal inside SARS-CoV-2.
1:02:14ENLex Fridman· 30 jun 2020Pódcast · 2 vocesThe 28-year wait: Robert Langer on rejection, polymers, and a thousand studentsInvitado: Robert Langer · Presenta: Lex FridmanThe MIT bioengineer talks with Lex Fridman about drug delivery, tissue engineering, patents, and the long path from a Folkman hypothesis to Avastin.
1:12:03ENLex Fridman· 5 may 2020Pódcast · 2 vocesMice Don't Get Alzheimer's: Daphne Koller on Disease in a DishInvitado: Daphne Koller · Presenta: Lex FridmanThe Coursera co-founder and insitro CEO on why most diseases are not one disease, how to turn cells into data, and why overconfident neural nets can kill.
2:09:02ENLex Fridman· 22 abr 2020Pódcast · 2 vocesA Hundred-Nanometer Machine That Is Not Quite AliveInvitado: Dmitry Korkin · Presenta: Lex FridmanDmitry Korkin walks through the structural genomics of SARS-CoV-2, from spike-ACE2 docking to drug-binding sites, vaccines, and cruise-ship simulations, recorded in the first spring of the pandemic.
58:03EN
Jane Street· 18 feb 2020Matt Might on an Algorithm for Precision MedicineMatt Might · University of Alabama at BirminghamA computer scientist describes how genetic data, experimental models and logic programming can help clinicians investigate difficult cases.
57:42ENLex Fridman· 12 ago 2019Pódcast · 2 vocesA Brain Organoid Is Not a BrainInvitado: Paola Arlotta · Presenta: Lex FridmanHarvard developmental biologist Paola Arlotta on how the cerebral cortex is built, why timing and mechanical force are part of the code, and why a dish of stem cells is only a window onto that process.
56:20EN
No Priors: AI, Machine Learning, Tech, & StartupsPódcast · 2 vocesBiohub's Bet: Building Open AI World Models of Biology From Proteins Up to CellsPresenta: Sarah Guo, Elad GilMark Zuckerberg, Priscilla Chan and Alex Rives explain why Biohub pairs a frontier AI lab with frontier wet-lab biology, and why it releases tools like ESMFold2 as open source.
11:51ENLex FridmanPódcastBuilding a Brain: Paola Arlotta on the Choreography of Human Brain DevelopmentPresenta: Lex FridmanA Harvard stem cell biologist walks through how the embryo builds the cerebral cortex, why order and environment matter, and why development continues into our twenties.
1:03:59EN
Cognitive Revolution "How AI Changes Everything"PódcastBuilding a World Model of Life: Biohub's Alex Rives on Why Better Measurement Must Come Before Virtual CellsPresenta: Nathan LabenzBiohub's head of science explains why today's virtual cell models fall short, how a $1.8 billion data push aims to fix it, and what a five-year information-level model of the cell could unlock.
1:45:55ENCognitive Revolution "How AI Changes Everything"PódcastFrom Static Structures to Moving Molecules: Where AI for Protein Design Stands After AlphaFold 3Presenta: Nathan LabenzComputational biochemist Amelie Schreiber walks Nathan Labenz through six months of progress in structure prediction, molecular dynamics, peptide and antibody models, and early agent-driven design workflows.