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4:05:51ENLife is the universe developing a memoryInvitado: Lee Cronin · Presenta: Lex FridmanChemist Lee Cronin tells Lex Fridman why life looks inevitable, how assembly theory could detect it on any world, and why silicon may never hold enough states for consciousness.
59:29ENHarley Finkelstein on Shopify, Leadership and Learning to Be Present at HomeInvitado: Harley Finkelstein · Presenta: Harry StebbingsThe Shopify president discusses communication, anxiety and the lessons he and his wife have learned about partnership and parenting.
2:49:41ENNazi Science Was Not Anti-Science. It Was Science with a Purity QuestInvitado: Robert Proctor · Presenta: Lex FridmanStanford historian Robert Proctor on how ideology, tobacco, and the taxonomic impulse turn scientists into widget-builders.
51:15ENAgility at Scale: Alignment, Autonomy and Two MindsetsDaniel Terhorst-North, Anna UrbaniakDaniel Terhorst-North and Anna Urbaniak discuss coordination and learning in large organizations.
45:59ENSahil Bloom on Building an Audience and Starting a Venture FundInvitado: Sahil Bloom · Presenta: Harry StebbingsThe writer and investor discusses consistent content, media-led investing, luck and a changing definition of hard work.
2:00:13ENHalf of America Dislikes Him. Zuckerberg Still Wants Presence, Not ScreensInvitado: Mark Zuckerberg · Presenta: Lex FridmanLex Fridman sits with Meta CEO Mark Zuckerberg on virtual presence, Instagram's teen research, free speech, and why every content decision costs the company half the country.
30:43ENJohn Doerr on Climate Investing, Google and a Plan for Net ZeroInvitado: John Doerr · Presenta: Harry StebbingsThe Kleiner Perkins investor discusses timing, portfolio risk and the measurable climate goals in Speed & Scale.
2:01:35ENA no-click iPhone exploit sold for $2.5 million. Silence was the only condition.Invitado: Nicole Perlroth · Presenta: Lex FridmanNicole Perlroth tells Lex Fridman how zero-days, ransomware, and a privately owned power grid turned curiosity into everyday cyberwar.
2:10:29ENDevon Larratt’s Only Priority Is Winning. Everything Else Is a ToolInvitado: Devon Larratt · Presenta: Lex FridmanLex Fridman sits with one of the greatest arm wrestlers of all time to talk John Brzenk, Levan Saginashvili, Russian volume, a weaponized voice, and why everybody is beatable.
2:37:03ENNo One Knows How to Make a PencilInvitado: Tim Urban · Presenta: Lex FridmanWait But Why's Tim Urban spent five years on a book about why society is tearing itself apart, then sat down with Lex Fridman to talk aliens, Musk, Neuralink, and the war inside a procrastinator's head.
2:17:29ENThe knowledge doctors trust is built to sell drugsInvitado: John Abramson · Presenta: Lex FridmanHarvard physician John Abramson tells Lex Fridman how pharmaceutical companies captured medical knowledge, and why American healthcare spends more while delivering less.
30:53ENMark Cuban on Cost Plus Drugs, Hiring and Healthcare PricingInvitado: Mark Cuban · Presenta: Harry StebbingsIn a 2022 interview, Cuban describes the pharmacy’s early pricing model, his self-funded venture and his views on the US healthcare system.
1:42:58ENDon't Talk Conclusions. Talk Data.Invitado: Garry Nolan · Presenta: Lex FridmanA Stanford immunologist sat through the brain scans of people who said they had met UFOs—and treats the rest of the subject the same way.
42:35ENMac Conwell on Building RareBreed and Supporting Overlooked FoundersInvitado: McKeever Conwell II · Presenta: Harry StebbingsThe investor describes his path into venture, fundraising through relationships on Twitter and his proposed changes to the industry.
2:46:31ENThe Official Scientific Worldview Is Incompatible With ConsciousnessInvitado: Philip Goff · Presenta: Lex FridmanDurham philosopher Philip Goff tells Lex Fridman why panpsychism — the view that consciousness is fundamental and ubiquitous — is the least-bad theory of mind.
2:59:02ENWhen the Answers Are Already Known, Look Where Everyone Stopped LookingPresenta: Lex FridmanGeorges St-Pierre, John Danaher, and Gordon Ryan sit with Lex Fridman to unpack success, confidence, training, and why the greatest of all time may not even be born yet.
2:16:40ENEach Blockbuster Is a Startup. The Chocolate River Kills It.Invitado: Thomas Tull · Presenta: Lex FridmanThomas Tull tells Lex Fridman how a novice raised institutional capital for Hollywood, then applied the same judgment to AI, mammoths, the Steelers, and a Rolling Stones tour.
45:16ENFrank Slootman on Focus, Performance and Leading a BoardInvitado: Frank Slootman · Presenta: Harry StebbingsSnowflake’s then-CEO discusses diagnosing problems, creating urgency, evaluating performance and giving capable teams room to act.
2:45:10ENA Teenager Learns to Drive in Twenty Hours. A Car Still Cannot.Invitado: Yann Lecun · Presenta: Lex FridmanYann LeCun tells Lex Fridman why self-supervised world models are the missing dark matter of intelligence, and why machines are not even at the level of a house cat.
1:24:16ENChris Sacca on Venture Investing, Climate and the Responsibilities of WealthInvitado: Chris Sacca · Presenta: Harry StebbingsThe investor reflects on early losses, founder relationships and Lowercarbon’s climate thesis, and explains his criticism of Facebook and SoftBank.
3:59:41ENDust Covered the Origin of the UniverseInvitado: Brian Keating · Presenta: Lex FridmanExperimental cosmologist Brian Keating on telescopes as time machines, the BICEP2 false alarm, and what it actually means to lose a Nobel Prize.
2:58:05ENThe Declaration of 1776 and the Constitution of 1787 Pull in Opposite DirectionsPresenta: Lex FridmanYaron Brook and Yoram Hazony spend three hours arguing whether a free society is built on the individual or on the sticky, hierarchical groups that individuals cannot live without.
1:50:07ENBombing Is Data: Mark Normand on Love, Comedy, and Eating Shit EarlyInvitado: Mark Normand · Presenta: Lex FridmanStand-up comedian Mark Normand talks with Lex Fridman about keeping love in shape, growing up the odd kid in New Orleans, why open-mic hell is comedy’s first level, and when a joke is finally done.
1:22:34ENStephen Dolan on Memory Management, Garbage Collection, and OCamlYaron Minsky, Stephen Dolan · Jane StreetFrom tracing and reference counting to prefetching, local allocation and unboxed types, Dolan explains the tradeoffs behind safe, efficient memory management.
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