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39:23EN
No Priors: AI, Machine Learning, Tech, & Startups· 15 oct 2026Pódcast · 2 vocesThe Defenders' Window: Greg Brockman on AI-Generated Knowledge, Drug Discovery, and the New Physics of CybersecurityPresenta: Sarah Guo, Elad GilOpenAI's president explains why solving open math problems is a proof point for science, how proactive agents change product form, and why security spending must exceed software spending.
29:26ENNo Priors: AI, Machine Learning, Tech, & Startups· 3 abr 2026Pódcast · 2 vocesChatGPT Almost Became a Meeting Bot. Its Co-Creator Is Now Rearranging AtomsPresenta: Sarah Guo, Elad GilLiam Fedus tells No Priors how Periodic Labs is connecting language models to experiments so materials science can run in a closed loop.
48:14ENNo Priors: AI, Machine Learning, Tech, & Startups· 13 nov 2025Pódcast · 2 vocesA New Drug Burns $2 Billion and 10 Years. Benchling's CEO Wants AI to Cut That to ThreePresenta: Sarah Guo, Elad GilMost medicines fail in years seven to ten, after hundreds of millions have already gone into the clinic—and Sajith Wickramasekara thinks sending things to space may already be easier.
49:27ENNo Priors: AI, Machine Learning, Tech, & Startups· 3 jul 2025Pódcast · 2 vocesFrom 0.1% to 20%: Chai-2 Turns Antibody Design Into Prompt EngineeringPresenta: Sarah Guo, Elad GilChai Discovery co-founders Joshua Meier and Jack Dent tell Sarah Guo how a generative model now designs antibodies that bind on the first 24-well plate.
42:09ENNo Priors: AI, Machine Learning, Tech, & Startups· 26 jun 2025Pódcast · 2 vocesAlphaEvolve found algorithms humans missed for 50 years — then sped up Gemini 23%Presenta: Sarah Guo, Elad GilGoogle DeepMind’s Pushmeet Kohli and Matej Balog tell No Priors how an evolutionary coding agent searches algorithm space the way AlphaGo searched Go.
40:54ENNo Priors: AI, Machine Learning, Tech, & Startups· 17 abr 2025Pódcast · 2 vocesDiscovery rates collapsed tenfold. KoBold still found a 5% copper depositPresenta: Sarah Guo, Elad GilJosh Goldman explains why KoBold Metals treats mineral exploration as an information problem, pairing AI with century-old maps to hunt lithium and copper.
40:33ENNo Priors: AI, Machine Learning, Tech, & Startups· 27 feb 2025Pódcast · 2 vocesModerna was only company 18. The real product is the company factoryPresenta: Sarah Guo, Elad GilNoubar Afeyan tells No Priors how Flagship Pioneering turned starting companies into a profession, underwrites scientific uncertainty, and wants AI to run discovery the way Waymo drives.
57:41ENNo Priors: AI, Machine Learning, Tech, & Startups· 25 feb 2025Pódcast · 2 vocesA Hundred Million Cells, Four People, Three Days: Biology's ImageNet MomentPresenta: Sarah Guo, Elad GilVevo Therapeutics and the Arc Institute open-sourced Tahoe-100M and a 230-million-cell atlas in the same week — and argued that virtual cells, not just protein folders, are the next language model of biology.
39:22ENNo Priors: AI, Machine Learning, Tech, & Startups· 14 nov 2024Pódcast · 2 vocesA Fields Medalist Stuck for Two Hours. AlphaProof Climbed for Three Days.Presenta: Sarah Guo, Elad GilThe DeepMind team behind AlphaProof tells Sarah Guo and Elad Gil how an AlphaZero-style agent, a Lean verifier, and test-time reinforcement learning reached IMO silver — and why the missing skill is still theory building.
37:01ENNo Priors: AI, Machine Learning, Tech, & Startups· 28 sept 2023Pódcast · 2 vocesDNA Is Code, but You Compile It with a PipettePresenta: Sarah Guo, Elad GilGinkgo Bioworks CEO Jason Kelly tells No Priors why cells are worth the magic, why biology has no AWS, and why a pandemic should look like cybersecurity.
35:24ENNo Priors: AI, Machine Learning, Tech, & Startups· 24 ago 2023Pódcast · 2 vocesThe Author of Attention Is All You Need Now Compiles mRNA Like BytecodePresenta: Sarah Guo, Elad GilJakob Uszkoreit on why Transformers won, why models spend compute on the wrong things, and why drug discovery has to become generation rather than screening.
46:57ENNo Priors: AI, Machine Learning, Tech, & Startups· 2 mar 2023Pódcast · 2 voces95% of Drug Programs Fail. Daphne Koller Is Betting Machine Learning on the First DecisionPresenta: Sarah Guo, Elad GilA new medicine still takes more than a decade and well over a billion dollars — and Insitro's founder argues the expensive failures start with the wrong target, indication, or patient.
56:20ENNo Priors: AI, Machine Learning, Tech, & StartupsPódcast · 2 vocesBiohub's Bet: Building Open AI World Models of Biology From Proteins Up to CellsPresenta: Sarah Guo, Elad GilMark Zuckerberg, Priscilla Chan and Alex Rives explain why Biohub pairs a frontier AI lab with frontier wet-lab biology, and why it releases tools like ESMFold2 as open source.