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3:18:09EN
Lex Fridman· Nov 30, 2025Podcast · 2 speakersA Thing Is Alive When Its Goals Outrun Its PartsGuest Michael Levin · Host Lex FridmanTufts biologist Michael Levin tells Lex Fridman that intelligence is a spectrum of persuadability, that even a bubble sort hosts unexpected goals, and that the brain is a thin client to a space physics does not own.
49:27EN
No Priors: AI, Machine Learning, Tech, & Startups· Jul 3, 2025Podcast · 2 speakersFrom 0.1% to 20%: Chai-2 Turns Antibody Design Into Prompt EngineeringHost Sarah Guo, Elad GilChai Discovery co-founders Joshua Meier and Jack Dent tell Sarah Guo how a generative model now designs antibodies that bind on the first 24-well plate.
37:01ENNo Priors: AI, Machine Learning, Tech, & Startups· Sep 28, 2023Podcast · 2 speakersDNA Is Code, but You Compile It with a PipetteHost Sarah Guo, Elad GilGinkgo Bioworks CEO Jason Kelly tells No Priors why cells are worth the magic, why biology has no AWS, and why a pandemic should look like cybersecurity.
2:18:25ENLex Fridman· Sep 1, 2023Podcast · 2 speakersGrow Everything: Neri Oxman on Giving Nature a VoteGuest Neri Oxman · Host Lex FridmanThe designer-scientist who left MIT to build OXMAN talks silkworm pavilions, bees in space, and why the end of human agency might be the start of nature's.
35:24ENNo Priors: AI, Machine Learning, Tech, & Startups· Aug 24, 2023Podcast · 2 speakersThe Author of Attention Is All You Need Now Compiles mRNA Like BytecodeHost Sarah Guo, Elad GilJakob Uszkoreit on why Transformers won, why models spend compute on the wrong things, and why drug discovery has to become generation rather than screening.
2:40:18ENLex Fridman· Dec 29, 2022Podcast · 2 speakersEvery Living Cell Runs the Same Translation MachineGuest Betül Kaçar · Host Lex FridmanAstrobiologist Betül Kaçar tells Lex Fridman how the tree of life is drawn backward, why nitrogen was fixed only once, and why the genetic code is an alphabet with room for typos.
3:00:21ENLex Fridman· Oct 1, 2022Podcast · 2 speakersCut Off a Planarian's Head. The New Brain Still RemembersGuest Michael Levin · Host Lex FridmanMichael Levin argues that DNA only builds hardware, bioelectric networks store body plans, and frog skin cells can become robots that evolution never designed.
3:43:01ENLex Fridman· Sep 7, 2022Podcast · 2 speakersPut Hydrogen and CO2 in a Tube. Thermodynamics Wants Cells. Nothing Happens.Guest Nick Lane · Host Lex FridmanBiochemist Nick Lane talks Lex Fridman through hydrothermal vents, mitochondria, sex, consciousness, and why bacteria should be common while civilizations are not.
2:10:39ENLex Fridman· Jul 1, 2022Podcast · 2 speakersDemis Hassabis: Solve Intelligence, Then Solve Everything ElseGuest Demis Hassabis · Host Lex FridmanThe DeepMind CEO tells Lex Fridman why the Turing Test is the wrong exam, how AlphaFold rewrote biology, and why the quiet radio sky suggests we are probably alone.
2:55:05ENLex Fridman· May 8, 2022Podcast · 2 speakersExtinction awareness is the human trait Mason wants to carry to the starsGuest Chris Mason · Host Lex FridmanCornell geneticist Chris Mason on why seeing our own end creates a duty to engineer life for other worlds — and what a 500-year plan would actually require.
1:26:53ENLex Fridman· Nov 5, 2021Podcast · 2 speakersFrancis Collins Cannot Exclude a Lab LeakGuest Francis Collins · Host Lex FridmanThe outgoing NIH director talks with Lex Fridman about COVID origins, gain-of-function research, Anthony Fauci, vaccines, and why scientific certainty is the wrong pose.
2:59:12ENLex Fridman· Jun 20, 2021Podcast · 2 speakersNature Never Dealt This CardGuest Rob Reid · Host Lex FridmanIn 2011 two labs independently engineered H5N1 so it could travel through the air between mammals — work Rob Reid tells Lex Fridman should never have been done, and still has not been stopped.
1:41:34ENLex Fridman· Jun 6, 2021Podcast · 2 speakersAging Is a Scratched Disc. David Sinclair Thinks the Body Kept a BackupGuest David Sinclair · Host Lex FridmanThe Harvard geneticist tells Lex Fridman why aging is information loss, how three genes gave a blind mouse its sight back, and why skipping meals may beat the perfect diet.
2:17:42ENLex Fridman· Jan 11, 2021Podcast · 2 speakersThe building block of life is a bead on a string, not the whole proteinGuest Dmitry Korkin · Host Lex FridmanDmitry Korkin tells Lex Fridman why protein domains, a triangular spike, and a conservative viral shell matter more than the AlphaFold headline, and why a Nobel laureate once answered a midnight forum post.
2:14:55ENLex Fridman· Nov 30, 2020Podcast · 2 speakersHis Wife Calls Him the RadioGuest Manolis Kellis · Host Lex FridmanMIT computational biologist Manolis Kellis spends the first forty minutes of his fourth Lex Fridman conversation on the songs that formed him, then turns to 42, dinosaurs, and why hunting for meaning matters more than finding it.
2:39:45ENLex Fridman· Oct 25, 2020Podcast · 2 speakersThe obesity gene was never the obesity geneGuest Manolis Kellis · Host Lex FridmanManolis Kellis tells Lex Fridman how one nucleotide a million bases from FTO rewrote obesity biology, and why human genetics is now driving the study of disease.
2:10:53ENLex Fridman· Sep 12, 2020Podcast · 2 speakersAll Your DNA Would Reach Jupiter a Hundred Times OverGuest Manolis Kellis · Host Lex FridmanManolis Kellis talks Lex Fridman through the epigenome, Neanderthals, Europa, midlife, and why "are you happy?" is the wrong question.
2:29:24ENLex Fridman· Jul 31, 2020Podcast · 2 speakersWe Are the Descendants of the First Digital ComputerGuest Manolis Kellis · Host Lex FridmanMIT computational biologist Manolis Kellis tells Lex Fridman why life is digital, why any two humans are 99.9 percent identical, and what evolutionary signatures reveal inside SARS-CoV-2.
1:02:14ENLex Fridman· Jun 30, 2020Podcast · 2 speakersThe 28-year wait: Robert Langer on rejection, polymers, and a thousand studentsGuest Robert Langer · Host Lex FridmanThe MIT bioengineer talks with Lex Fridman about drug delivery, tissue engineering, patents, and the long path from a Folkman hypothesis to Avastin.
1:12:03ENLex Fridman· May 5, 2020Podcast · 2 speakersMice Don't Get Alzheimer's: Daphne Koller on Disease in a DishGuest Daphne Koller · Host Lex FridmanThe Coursera co-founder and insitro CEO on why most diseases are not one disease, how to turn cells into data, and why overconfident neural nets can kill.
2:09:02ENLex Fridman· Apr 22, 2020Podcast · 2 speakersA Hundred-Nanometer Machine That Is Not Quite AliveGuest Dmitry Korkin · Host Lex FridmanDmitry Korkin walks through the structural genomics of SARS-CoV-2, from spike-ACE2 docking to drug-binding sites, vaccines, and cruise-ship simulations, recorded in the first spring of the pandemic.
57:42ENLex Fridman· Aug 12, 2019Podcast · 2 speakersA Brain Organoid Is Not a BrainGuest Paola Arlotta · Host Lex FridmanHarvard developmental biologist Paola Arlotta on how the cerebral cortex is built, why timing and mechanical force are part of the code, and why a dish of stem cells is only a window onto that process.
56:20ENNo Priors: AI, Machine Learning, Tech, & StartupsPodcast · 2 speakersBiohub's Bet: Building Open AI World Models of Biology From Proteins Up to CellsHost Sarah Guo, Elad GilMark Zuckerberg, Priscilla Chan and Alex Rives explain why Biohub pairs a frontier AI lab with frontier wet-lab biology, and why it releases tools like ESMFold2 as open source.