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31:39EN
No Priors: AI, Machine Learning, Tech, & Startups· Aug 20, 2026Podcast · 2 speakersThe Skull Is Already the Vat: Max Hodak on Restoring SightHost Sarah Guo, Elad GilPatients blinded by macular degeneration put on laser-projector glasses, read books, and fill in Sudoku — because a chip under the retina is sending vision back into the brain.
48:14ENNo Priors: AI, Machine Learning, Tech, & Startups· Nov 13, 2025Podcast · 2 speakersA New Drug Burns $2 Billion and 10 Years. Benchling's CEO Wants AI to Cut That to ThreeHost Sarah Guo, Elad GilMost medicines fail in years seven to ten, after hundreds of millions have already gone into the clinic—and Sajith Wickramasekara thinks sending things to space may already be easier.
44:49ENNo Priors: AI, Machine Learning, Tech, & Startups· Sep 5, 2025Podcast · 2 speakersHow OpenEvidence Became the Clinical OS for 40% of U.S. DoctorsHost Sarah Guo, Elad GilFounder Daniel Nadler tells No Priors how a free search tool for physicians, not an answer engine for patients, took high-stakes clinical knowledge in 18 months.
49:27ENNo Priors: AI, Machine Learning, Tech, & Startups· Jul 3, 2025Podcast · 2 speakersFrom 0.1% to 20%: Chai-2 Turns Antibody Design Into Prompt EngineeringHost Sarah Guo, Elad GilChai Discovery co-founders Joshua Meier and Jack Dent tell Sarah Guo how a generative model now designs antibodies that bind on the first 24-well plate.
38:43ENNo Priors: AI, Machine Learning, Tech, & Startups· Mar 27, 2025Podcast · 2 speakersTwo in Five Doctors Want Out. An On-Call Cardiologist Built the Note That Lets Them StayHost Sarah Guo, Elad GilAbridge CEO Shiv Rao on treating the doctor-patient conversation as healthcare's source of truth, and why the company ran straight at the hardest health systems.
42:18ENNo Priors: AI, Machine Learning, Tech, & Startups· May 18, 2023Podcast · 2 speakersTen Percent of Search Is Health — and the Doctor Is Googling TooHost Sarah Guo, Elad GilGoogle researcher Karan Singhal on Med-PaLM 2, the real bar for medical language models, and why medicine is a harder alignment lab than chatbots.
46:57ENNo Priors: AI, Machine Learning, Tech, & Startups· Mar 2, 2023Podcast · 2 speakers95% of Drug Programs Fail. Daphne Koller Is Betting Machine Learning on the First DecisionHost Sarah Guo, Elad GilA new medicine still takes more than a decade and well over a billion dollars — and Insitro's founder argues the expensive failures start with the wrong target, indication, or patient.
50:12ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 20, 2023Podcast · 2 speakersThe Drone Is Only 15 Percent of the ProblemHost Sarah Guo, Elad GilZipline CEO Keller Rinaudo Cliffton on why blood delivery in Rwanda, not a cooler airplane, built the world's largest commercial autonomous system.
2:43:51EN
Lex Fridman· Jun 25, 2022Podcast · 2 speakersTwo Tubes, Millimeters Apart: Jonathan Reisman on the Honest Design of the Human BodyGuest Jonathan Reisman · Host Lex FridmanThe emergency physician and author of The Unseen Body walks Lex Fridman from the throat to the Arctic, arguing that anatomy is mostly brilliant, sometimes a near-miss, and always a story written in scars.
3:21:29ENLex Fridman· Apr 7, 2022Podcast · 2 speakersWhen something in the mind breaks, you see what it was forGuest Karl Deisseroth · Host Lex FridmanStanford psychiatrist Karl Deisseroth talks with Lex Fridman about depression, schizophrenia, optogenetics, and why you can treat one symptom without a theory of everything.
1:41:34ENLex Fridman· Jun 6, 2021Podcast · 2 speakersAging Is a Scratched Disc. David Sinclair Thinks the Body Kept a BackupGuest David Sinclair · Host Lex FridmanThe Harvard geneticist tells Lex Fridman why aging is information loss, how three genes gave a blind mouse its sight back, and why skipping meals may beat the perfect diet.
2:31:30ENLex Fridman· May 24, 2021Podcast · 2 speakersThe Brain Is the Last Unengineered System in SocietyGuest Bryan Johnson · Host Lex FridmanBryan Johnson demos Kernel Flow on Lex Fridman, then argues that cognition is society's largest unmeasured input and that numbers, not vibes, should run mental health, diet, and the next wave of brain interfaces.
2:39:45ENLex Fridman· Oct 25, 2020Podcast · 2 speakersThe obesity gene was never the obesity geneGuest Manolis Kellis · Host Lex FridmanManolis Kellis tells Lex Fridman how one nucleotide a million bases from FTO rewrote obesity biology, and why human genetics is now driving the study of disease.
1:02:14ENLex Fridman· Jun 30, 2020Podcast · 2 speakersThe 28-year wait: Robert Langer on rejection, polymers, and a thousand studentsGuest Robert Langer · Host Lex FridmanThe MIT bioengineer talks with Lex Fridman about drug delivery, tissue engineering, patents, and the long path from a Folkman hypothesis to Avastin.
1:12:03ENLex Fridman· May 5, 2020Podcast · 2 speakersMice Don't Get Alzheimer's: Daphne Koller on Disease in a DishGuest Daphne Koller · Host Lex FridmanThe Coursera co-founder and insitro CEO on why most diseases are not one disease, how to turn cells into data, and why overconfident neural nets can kill.
36:10ENLex Fridman· Nov 12, 2019Podcast · 2 speakersSo You're Saying There's a Chance: Musk on Neuralink, AI, and a Pale Blue DotGuest Elon Musk · Host Lex FridmanLex Fridman and Elon Musk move from consciousness and an AI referee to the engineering of a brain implant, Tesla Autopilot, and Carl Sagan's lonely speck.
1:17:29ENLex Fridman· Sep 23, 2019Podcast · 2 speakersThe Algorithm Is Already Better. The Clinic Still Uses 1967.Guest Regina Barzilay · Host Lex FridmanMIT's Regina Barzilay on why deep learning already beats the breast-cancer 'density' score — and why data, liability, and incentives still will not move.
1:00:11ENLex Fridman· Jun 17, 2019Podcast · 2 speakersRosalind Picard: Clippy Never Saw You Frown, and That's the Whole ProblemGuest Rosalind Picard · Host Lex FridmanThe MIT professor who named affective computing on emotion recognition, privacy, seizure-detecting wearables, and why a device you can take off is safer than a camera you cannot see.
33:07ENLex Fridman· Dec 4, 2018Podcast · 2 speakersThey Ran an Extension Cord Next Door and Invented GoogleGuest Eric Schmidt · Host Lex FridmanEric Schmidt tells Lex Fridman that Larry and Sergey never held the entrepreneurship meeting: they had a better algorithm, too little power in the dorm, and a $100,000 check.