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1:09:44EN
No Priors: AI, Machine Learning, Tech, & Startups· Oct 9, 2026Podcast · 2 speakers10,000 GB300s for Four Weeks: Reflection’s Open-Model LedgerHost Sarah Guo, Elad GilMisha Laskin tells No Priors how Reflection trained Beam, why reinforcement learning outspent pre-training, and why the West needs its own open weights.
40:54ENNo Priors: AI, Machine Learning, Tech, & Startups· Aug 28, 2025Podcast · 2 speakersSeventeen Years of Flat Power, and a Plan to Bring the Factories HomeHost Sarah Guo, Elad GilJacob Helberg, the under secretary of state designate for economic growth, energy, and the environment, argues that nuclear power and AI productivity—not cheap labor—are how America reshore its supply chain.
47:18ENNo Priors: AI, Machine Learning, Tech, & Startups· Aug 14, 2025Podcast · 2 speakersThe Analyst Tracking 200 GPU Clouds Breaks Nvidia Into a Three-Headed DragonHost Sarah Guo, Elad GilSemiAnalysis founder Dylan Patel on OpenAI’s open-weight model, a coming neocloud wipeout, and why a chip startup has to beat Nvidia on hardware, networking, and software at once.
36:48ENNo Priors: AI, Machine Learning, Tech, & Startups· Jul 31, 2025Podcast · 2 speakersThe Weekend DeepSeek Dropped, the White House CalledHost Sarah Guo, Elad GilSriram Krishnan walks No Priors through America’s 28-page AI Action Plan, a token-share definition of winning, and why the lead over China is too small to take for granted.
35:14ENNo Priors: AI, Machine Learning, Tech, & Startups· Mar 20, 2025Podcast · 2 speakersRobots Have No Wikipedia. Chelsea Finn Is Starting With Three Buildings.Host Sarah Guo, Elad GilPhysical Intelligence’s cofounder tells No Priors why a generalist robot model has to be trained across embodiments, why open-sourcing hardware is a bet against the problem going unsolved, and why humanoids are a little overrated.
57:41ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 25, 2025Podcast · 2 speakersA Hundred Million Cells, Four People, Three Days: Biology's ImageNet MomentHost Sarah Guo, Elad GilVevo Therapeutics and the Arc Institute open-sourced Tahoe-100M and a 230-million-cell atlas in the same week — and argued that virtual cells, not just protein folders, are the next language model of biology.
38:05ENNo Priors: AI, Machine Learning, Tech, & Startups· Dec 5, 2024Podcast · 2 speakersFrom Zero to $20M ARR in Two Months: Bolt's Moat Lives in the BrowserHost Sarah Guo, Elad GilStackBlitz CEO Eric Simons tells No Priors how a five-year WebContainers bet, an open-sourced prompt, and a community of non-coders turned Bolt.new into an overnight full-stack generator.
42:59ENNo Priors: AI, Machine Learning, Tech, & Startups· Aug 29, 2024Podcast · 2 speakersAWS Is a $100 Billion Cloud. Matt Garman Still Sees a 10x Migration AheadHost Sarah Guo, Elad GilAmazon Web Services’ new CEO tells No Priors why 85 percent of workloads are still on-prem, how Bedrock was built from three bets, and why startups remain the company’s growth engine.
26:00ENNo Priors: AI, Machine Learning, Tech, & Startups· Jun 11, 2024Podcast · 2 speakersWhy a Zapier founder thinks AGI research has been stalled for four yearsHost Sarah Guo, Elad GilMike Knoop and François Chollet put more than a million dollars on beating ARC-AGI, the eval they say actually measures general intelligence.
39:03ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 29, 2024Podcast · 2 speakersMI300 Leads Inference by 2x: AMD's CTO on Winning Chip Competition Without a Walled GardenHost Sarah Guo, Elad GilWhen Mark Papermaster became AMD's CTO in fall 2011, nearly all of the company's revenue sat on PCs and gaming, Moore's Law was slowing, and everyone knew it needed a turnaround.
39:36ENNo Priors: AI, Machine Learning, Tech, & Startups· Dec 14, 2023Podcast · 2 speakersThe Most Underestimated AI Buyer Is the Shop on the CornerHost Sarah Guo, Elad GilFormer Square CEO Alyssa Henry tells No Priors that generative AI is unlocking work small merchants always needed and never paid anyone to do.
32:57ENNo Priors: AI, Machine Learning, Tech, & Startups· Nov 9, 2023Podcast · 2 speakersA 7-billion-parameter model on a MacBook: Mistral's CEO reruns the cost of AIHost Sarah Guo, Elad GilArthur Mensch tells No Priors why Chinchilla made small models valuable, why open-sourcing Mistral 7B is not a bioweapon risk, and why guardrails belong on the application.
29:38ENNo Priors: AI, Machine Learning, Tech, & Startups· Sep 21, 2023Podcast · 2 speakersA Beginner Just Shipped a $250K Business. Professionals Got 30 Percent.Host Sarah Guo, Elad GilReplit CEO Amjad Masad on Ghostwriter, why a 3-billion-parameter model was enough, and the agents he wants earning bounties while you sleep.
37:26ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 23, 2023Podcast · 2 speakersWithout Open Source, Machine Learning Would Be Decades BehindHost Sarah Guo, Elad GilHugging Face CEO Clem Delangue on the Tamagotchi pivot, why the company never hired a community manager, and why he does not believe one model will rule them all.
45:03ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 16, 2023Podcast · 2 speakersEmad Mostaque’s bet: open small models, not one giant brainHost Sarah Guo, Elad GilStability AI’s founder tells No Priors why foundation models should be public infrastructure, why small models can beat giant ones, and what that means for media, medicine, and AGI.
56:20ENNo Priors: AI, Machine Learning, Tech, & StartupsPodcast · 2 speakersBiohub's Bet: Building Open AI World Models of Biology From Proteins Up to CellsHost Sarah Guo, Elad GilMark Zuckerberg, Priscilla Chan and Alex Rives explain why Biohub pairs a frontier AI lab with frontier wet-lab biology, and why it releases tools like ESMFold2 as open source.
23:54ENNo Priors: AI, Machine Learning, Tech, & StartupsPodcast · 2 speakersBeyond GPT-7: The Customization Toolkit, Meta's Open Source Bet and the Return of Consumer AIHost Sarah Guo, Elad GilIn a host-only episode, the No Priors hosts map the six levers for 10x to 100x better AI, explain fine-tuning, RAG and AI feedback, and ask why consumer social is suddenly interesting again.
33:31ENNo Priors: AI, Machine Learning, Tech, & StartupsPodcast · 2 speakersOpen Source Catches Up, Regulation Can Wait: Sarah Guo and Elad Gil Answer Listener QuestionsHost Sarah Guo, Elad GilTwo AI investors cover open-source models, autonomous agents, whether to regulate AI, where startups can win, and why healthcare innovation is so hard.