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3:36:56ENPsychiatry Has Never Found Its PenicillinHost Lex FridmanHistorian Andrew Scull tells Lex Fridman why the field can ease symptoms, has never cured a major mental illness, and keeps paying for overconfidence with patients' lives.
2:12:22ENIf It Is Not a Hundred Percent, It Is Not Happening: Huberman on Loyalty, Covert Contracts, and LoveGuest Andrew Huberman · Host Lex FridmanOn Lex Fridman's birthday, Andrew Huberman flew to Austin for dinner, talked into the night, and they recorded a last-minute podcast about the body, the shadow, betrayal, sex, and peace.
3:25:22ENAndrew Huberman Lets No One Near Him for Two Hours Before a PodcastGuest Andrew Huberman · Host Lex FridmanThe Stanford neuroscientist talks with Lex Fridman about building mental states, heat and cold, visual focus, and the four arrows of a relationship.
3:21:29ENWhen something in the mind breaks, you see what it was forGuest Karl Deisseroth · Host Lex FridmanStanford psychiatrist Karl Deisseroth talks with Lex Fridman about depression, schizophrenia, optogenetics, and why you can treat one symptom without a theory of everything.
1:11:03ENCarl Hart’s case that addiction lives outside the moleculeGuest Carl Hart · Host Lex FridmanThe Columbia psychologist tells Lex Fridman that most drug effects are positive, that alcohol withdrawal is deadlier than heroin’s, and that the war on drugs pays a long list of people to keep a scapegoat in place.
1:30:40ENI'm Giving You This Feedback Because I Believe in YouGuest Jo Boaler · Host Lex FridmanStanford mathematician Jo Boaler on visual math, why struggle only works if you think you can get there, and how a 90-minute class raised classroom engagement 68 percent.
3:39:01ENMatthew Johnson on loosening the priors that run a human lifeGuest Matthew Johnson · Host Lex FridmanThe Johns Hopkins psychiatrist walks Lex Fridman through receptors, addiction, DMT entities, a 15-person smoking trial, and why psychedelics have taught us almost nothing about the hard problem of consciousness.
2:20:31ENThe Most Romantic Gift Lisa Feldman Barrett Ever Got Was a Six-Way PlugGuest Lisa Feldman Barrett · Host Lex FridmanOn her second Lex Fridman Podcast, the neuroscientist traces how she fell in love over a 1992 bulletin board, why brains evolved to hunt rather than to think, and how a body budget can change a mood.
2:35:30ENOn a Perfectly Flat Floor, Heights Still WorkGuest Andrew Huberman · Host Lex FridmanStanford neuroscientist Andrew Huberman talks with Lex Fridman about fear circuits, matching inner arousal to outer demand, and why the first minutes after sleep should not belong to someone else's timeline.
11:51ENBuilding a Brain: Paola Arlotta on the Choreography of Human Brain DevelopmentHost Lex FridmanA Harvard stem cell biologist walks through how the embryo builds the cerebral cortex, why order and environment matter, and why development continues into our twenties.
1:17:38ENBrains Are Body Regulators: Lisa Feldman Barrett on Why Emotions Are Constructed, Not DetectedGuest Lisa Feldman Barrett · Host Lex FridmanIn a guest talk for MIT's AGI course, neuroscientist Lisa Feldman Barrett explains why faces don't display emotions, why brains exist to run bodies, and what that means for building human-like AI.








