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38:14ENDiffusion Will Win Inference: Stefano Ermon Bets Parallel Tokens Beat Custom SiliconHost Sarah Guo, Elad GilThe Stanford diffusion pioneer tells No Priors why a 50-person lab is training language models that generate many tokens at once — and why that maps to GPUs the way transformers once mapped to training.
1:01:27ENTwo Years and Four Months to a Live Reactor: Valar Atomics Wants Energy Ten Times CheaperHost Sarah Guo, Elad GilIsaiah Taylor walks Sarah Guo through Ward 250 in Utah and argues that nuclear is a hardware-iteration problem, not a paper-design one.
30:47ENEmbryos Survive 30 Years Frozen. Until Wants Organs to Stop Racing Private JetsHost Sarah Guo, Elad GilLaura Deming on reversible cryopreservation: pause an organ—and someday a patient—so a few months no longer decide who lives long enough for the next therapy.
46:26ZH → EnglishXiaohu Zhu: No Bubble in Sight for Three Years — When Consensus Is Too Concentrated, Offset by Fifteen DegreesGuest 朱啸虎 · Host 张小珺At the end of 2025, Xiaohu Zhu of GSR Ventures sat down with Zhang Xiaojun for the third time: AGI is off the table, and the fight for the entry point has begun. He skips humanoid robots and writes checks to companies that actually do the work — ship cleaning, massage.
2:36:55ENOne Second of Fuel: David Kirtley on Fusion Power by 2028Guest David Kirtley · Host Lex FridmanThe Helion Energy CEO walks Lex Fridman from 1958 theta pinches to a Microsoft contract that wants first electrons on the grid in 2028.
31:57ENPeak 700 GW, average 300 GW: Base Power is wiring home batteries into a power plantHost Sarah Guo, Elad GilZach Dell tells Elad Gil how a $1.3 billion raise, a Texas-only retail business, and a Tesla-and-SpaceX hiring bench are meant to cut the cost of moving an electron.
1:01:49ENTwo Academic Hours a Day, and 96 Percent of Kids Say They Love SchoolHost Sarah Guo, Elad GilTrilogy founder Joe Liemandt, now principal of Alpha School, tells No Priors how an AI tutor, a two-hour bargain with fifth graders, and a sports-coach ethos are meant to scale to a billion children.
44:49ENHow OpenEvidence Became the Clinical OS for 40% of U.S. DoctorsHost Sarah Guo, Elad GilFounder Daniel Nadler tells No Priors how a free search tool for physicians, not an answer engine for patients, took high-stakes clinical knowledge in 18 months.
1:49:29ENChina Is Not Run by One Person. It Is a Mayor EconomyGuest Keyu Jin · Host Lex FridmanEconomist Keyu Jin on local GDP races, DeepSeek, tariffs, Jack Ma, and why Western collapse forecasts keep missing the country they describe.
40:54ENDiscovery rates collapsed tenfold. KoBold still found a 5% copper depositHost Sarah Guo, Elad GilJosh Goldman explains why KoBold Metals treats mineral exploration as an information problem, pairing AI with century-old maps to hunt lithium and copper.
23:37ENA Hundred GPUs in Seconds: Why Modal Threw Out Docker and KubernetesHost Sarah Guo, Elad GilErik Bernhardsson tells Elad Gil that AI inference is too bursty for year-long GPU contracts, and that the cloud should feel as fast as a laptop.
26:08ENFewer Than 3% of Deals Get Investigated. Selling to the Monopolist Is What Triggers the FTC.Host Sarah Guo, Elad GilChair Lina Khan tells No Priors how merger review actually works in AI markets, why open-weight models matter, and why the agency banned most non-competes.
42:42ENEthereum Once Held Two Thousand GPT-3 Clusters of GPUsHost Sarah Guo, Elad GilFoundry CEO Jared Quincy Davis on idle H100s, why today's AI cloud is still colocation, and how compound systems move work off giant interconnected clusters.
34:09ENFive Independent Teams Found the Same 10-to-1 Mix That Beats TransformersHost Sarah Guo, Elad GilThe authors of S4 and Mamba argue that mostly state-space layers plus a dash of attention is the architecture that actually works—and they are shipping it first as real-time speech.
1:47:08ENKimbal Musk Cooks So People Will Sit DownGuest Kimbal Musk · Host Lex FridmanThe chef, Tesla board member, and author of The Kitchen Cookbook talks with Lex Fridman about apartheid South Africa, a broken neck, Zip2, and why a table beats a nightclub.
36:22ENOne Attacker and a For Loop: Why Email Is Still the Softest Target in an AI Arms RaceHost Sarah Guo, Elad GilMaterial Security co-founder Ryan Noon on how 2016 election hacks, Google and Microsoft's email duopoly, and large language models are rewriting both sides of cybersecurity.
3:33:04ENAfrica's Poverty Is Made of Laws, Not of PeopleGuest Magatte Wade · Host Lex FridmanSenegalese entrepreneur Magatte Wade tells Lex Fridman how tariffs, Napoleonic codes, and a Cold War wrong turn keep the world's youngest continent poor.
2:46:26ENApple Was a $5 Billion Company in Debt When Tony Fadell Built the iPodGuest Tony Fadell · Host Lex FridmanLex Fridman talks with Tony Fadell, co-creator of the iPod, iPhone, and Nest Thermostat, about the decisions, fights, and luck behind those products.
1:46:49ENAriel Ekblaw on Self-Assembling Habitats and Why the Real Space Cities Will FloatGuest Ariel Ekblaw · Host Lex FridmanThe MIT Space Exploration Initiative director talks swarm tiles, lunar ants, and why Mars is a research station rather than a backup Earth.
2:59:57ENThe Farmer With a $50 Phone: Sergey Nazarov on Oracles, Trust, and Hybrid Smart ContractsGuest Sergey Nazarov · Host Lex FridmanThe Chainlink co-founder tells Lex Fridman how definitive truth, oracle networks, and cryptographically guaranteed contracts could leapfrog banks, insurers, and marble-column confidence.
2:31:14ENAnonymity Is a Tool: How a Yale Freshman Built a Campus Where Students Could SpeakGuest Ryan Schiller · Host Lex FridmanRyan Schiller tells Lex Fridman how a silenced seminar, a Gallup number, and a Mac bought off YouTube advice became Librex, an anonymous discussion feed for verified college communities.
1:53:41ENSilvio Micali: Money Is a Shared Belief, and a Blockchain Makes It Common KnowledgeGuest Silvio Micali · Host Lex FridmanThe Turing Award cryptographer and Algorand founder tells Lex Fridman why ledgers, lotteries, and one-way functions matter more than mining.
2:16:07ENAsk What Could Go Right: Jason Calacanis on Robinhood, Loyalty, and Two Checks for TeslaGuest Jason Calacanis · Host Lex FridmanThe angel investor and All-In co-host walks Lex Fridman from a Palo Alto dive bar to GameStop, Silicon Valley’s war on friction, and a friendship that kept a car company alive for twelve extra days.
1:39:29ENElectric engines, 20-nanometer cones, and why Natalya Bailey would skip the first thousand on MarsGuest Natalya Bailey · Host Lex FridmanThe Accion Systems founder walks Lex Fridman from ion physics to orbital debris, chip-made thrusters, and the kind of culture that oozes out of a founder.
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