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17:56ENHow Bridgewater Keeps Its AI Analyst Inside Permission BoundariesNikhil Benesch, Aaron Linsky · turbopufferAaron Linsky and Nikhil Benesch explain why search over an enterprise vault must honor document permissions without sacrificing recall or speed. Their solution combines vector indexing with native filtering to search hundreds of millions of vectors in roughly 120 milliseconds.
13:21ENAdrian Twarog: Giving Enterprise Vibe Coding a Governed Path to ProductionAdrian TwarogA Superblocks walkthrough shows how shared integrations, isolated databases, policy agents and audit logs can bring business-built AI apps under IT oversight.
1:17:09EN20VC on Pro Rata Rights, AI Pricing and the Changing Software MarketGuest Jason Lemkin, Rory O’Driscoll · Host Harry StebbingsHarry Stebbings, Jason Lemkin and Rory O’Driscoll debate investor rights, model economics and the choices facing software companies and their employees.
34:51ENGoogle Paid $10 Million for a Bankrupt Airline’s Data. That’s the Moat.Host Sarah Guo, Elad GilEon co-founders Ofir Ehrlich and Gonen Stein argue that models and compute are rented commodities — the only asset enterprises can actually keep is their data.
2:33:35ENA security researcher audits the AI stack that booked a week of guestsHost Nathan LabenzNathan Labenz walks Daniel Miessler through a 1GB second brain, two named AI employees, and the blast-radius rules that should govern them.
1:43:39ENFive Mutations Could Make a 60% Fatal Bird Flu Spread Between PeopleHost Nathan LabenzJohns Hopkins assistant professor Jassi Pannu argues for locking down only the sliver of functional data that teaches models how to make pandemic viruses — and keeping the rest of biology open.
2:03:56EN260 Doctors and 49,000 Criteria: How OpenAI Built Attending-Level Health AIHost Nathan LabenzKaran Singhal tells Nathan Labenz how ChatGPT Health was evaluated with physicians, walled off from model training, and aimed at raising both the floor and the ceiling of human health.
1:18:40ENWhen AI Becomes the Oil Well: Luke Drago on the Intelligence CurseHost Nathan LabenzThe Workshop Labs co-founder tells the FLI Podcast why a world of non-human production could recreate the resource curse — and how private data, open weights, and moonshot careers might still break it.
1:32:47ENA transformer co-author wants a $160 million model no company ownsHost Nathan LabenzIllia Polosukhin tells Nathan Labenz how NEAR turned a payments headache into a stack for private inference, shared-revenue training, and AI agents that still answer to a court.
57:45ENThe last thing a totalitarian state can take is love — a reread of Orwell’s 1984Host Lex FridmanLex Fridman walks back through Oceania’s machinery of Newspeak, Doublethink, and Room 101, and argues that hate-fueled rebellion is not a way out.
31:29ENRippling skipped the chatbot and stamped employees after 90 days of workHost Sarah Guo, Elad GilCOO Matt MacInnis tells No Priors how Talent Signal reads source code, tickets, and customer conversations, then gives managers one calibrated label: high potential, typical, or pay attention.
1:25:10ENA Tenth of Google's Index, 99.9% Recall: How 20 People Built Brave SearchHost Nathan LabenzJosep M. Pujol walks Cognitive Revolution through Brave's privacy-first index, hybrid retrieval stack, and the Search API Nathan Labenz now wants his own product team to use.
2:09:50ENHe stayed up all night playing Civilization 6 with his mindHost Nathan LabenzDean W. Ball surveys EEG, ultrasound stimulation, and Neuralink with Nathan Labenz, and argues that merging with machines started decades ago.
1:44:23ENYou Can Split Your Vote by Issue — and Hand It to an AIHost Nathan LabenzTim Reutemann’s 2018 novel Liquid Reign sketches a 2051 democracy built on Swiss citizen initiatives, liquid delegation, and personal AIs you can mute.
3:04:22ENA Ten-Page Memo Told Tucker Carlson Not to Interview PutinGuest Tucker Carlson · Host Lex FridmanAfter eight days in Moscow, Carlson tells Lex Fridman why he let Vladimir Putin talk, what Navalny’s death does and does not prove, and why he thinks Washington is blocking a settlement in Ukraine.
1:21:50ENA 16K Context Window Holds About 350 Rows. That's Why Tables Need an Agent.Host Nathan LabenzGretel AI founder Alex Watson tells Nathan Labenz why most company data is still a spreadsheet, why GPT-4 is the wrong tool for generating it, and how differential privacy lets a model learn a disease without learning a patient.
1:20:06ENAccuracy Dropped From 93% to 7% — Cryptography Wants to Put a Dashcam on AIHost Nathan LabenzDaniel Kang explains how zero-knowledge proofs could verify that a model ran as promised, and that a user is human, without exposing weights or biometrics.
1:51:12ENHarvey Silverglate Would Fire 95 Percent of Harvard's AdministratorsGuest Harvey Silverglate · Host Lex FridmanThe FIRE co-founder, running as a write-in for Harvard's Board of Overseers, tells Lex Fridman why hate speech is more useful than love speech and why discomfort is the price of a free campus.
1:10:11ENTrying ChatGPT is not the same as using itHost Nathan LabenzRachel Woods of The AI Exchange tells Nathan Labenz what she learned from more than a hundred company calls: start inside the business, skip the annual tool contract, and expect to be using only a sliver of what the models can already do.
2:56:02ENThe FBI Never Cracked a Password the Day They Took Silk RoadGuest Chris Tarbell · Host Lex FridmanFormer agent Chris Tarbell tells Lex Fridman how a timezone setting, a Gmail address, and an undercover admin brought down Ross Ulbricht — and why the best hackers are still out there.
3:03:33ENA Robot Is Whatever Still Has MagicGuest Kate Darling · Host Lex FridmanKate Darling tells Lex Fridman why grocery-store Marty is a real-life Clippy, why animal history is a better guide than humanoid fantasy, and what the Epstein scandal revealed about MIT.
3:53:09ENThe CIA Serves One Customer, and That Customer Is the PresidentGuest Andrew Bustamante · Host Lex FridmanFormer covert officer Andrew Bustamante walks Lex Fridman through how American intelligence actually works — from the President's Daily Brief to Ukraine, Snowden, and a bar wall in Alabama.
2:29:24ENA Hundred Users Signed Up and Never Came BackGuest Brian Armstrong · Host Lex FridmanCoinbase CEO Brian Armstrong on the buy button that found product-market fit, why he wants customers to leave his platform, and a company that refuses to be a political square.
3:47:25ENThe Original Internet Godfather Built Trust Among CybercriminalsGuest Brett Johnson · Host Lex FridmanLex Fridman talks with Brett Johnson about ShadowCrew, social engineering, prison, and why most attacks still use holes everyone already knows about.
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