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3:36:56EN
Lex Fridman· Sep 16, 2026PodcastPsychiatry Has Never Found Its PenicillinHost Lex FridmanHistorian Andrew Scull tells Lex Fridman why the field can ease symptoms, has never cured a major mental illness, and keeps paying for overconfidence with patients' lives.
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Cognitive Revolution "How AI Changes Everything"· Aug 16, 2026PodcastA $500 Lamp Cut TB Transmission 90 Percent. Almost Nobody Buys OneHost Nathan LabenzAerolamp's Misha Gurevich and Vivian Belenky walk Patrick McKenzie through far-UVC at 222 nanometers: the lab science, the safety case, and why the bottleneck is awareness rather than physics.
2:06:09ENCognitive Revolution "How AI Changes Everything"· Dec 14, 2025PodcastOne ChatGPT query is a second in the microwaveHost Nathan LabenzAndy Masley walks Nathan Labenz through the energy and water math of AI, from a single prompt to an 80-gigawatt buildout.
1:29:30ENCognitive Revolution "How AI Changes Everything"· Oct 14, 2025Podcast2,500 Compounds and a 51 Percent Hit Rate: How a Small Graph Net Found New AntibioticsHost Nathan LabenzMIT's Jim Collins tells Nathan Labenz how a bootlegged 2018 project, a binary growth-inhibition label, and Chemprop graph networks pulled novel antibiotics out of chemical space that labs could never screen by hand.
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No Priors: AI, Machine Learning, Tech, & Startups· Jan 30, 2025Podcast · 2 speakersWhy Rick Caruso's Palisades Village Stood While Two Manhattans BurnedHost Sarah Guo, Elad GilThe Los Angeles developer and former mayoral candidate on empty hydrants, 40 years of uncut brush, and rebuilding in a year instead of a decade.
37:58ENNo Priors: AI, Machine Learning, Tech, & Startups· Jan 23, 2025Podcast · 2 speakersThe Forest Will Burn. The Only Question Is on Whose Terms.Host Sarah Guo, Elad GilConvective Capital’s Bill Clerico walks through why California’s wildfires reached a crescendo, and which wounds are still self-inflicted enough to fix.
1:02:32ENLex Fridman· Oct 23, 2024PodcastThe More Important the Issue, the Less Anyone Discusses ItHost Lex FridmanBernie Sanders tells Lex Fridman why drug lobbyists, campaign cash, and a healthcare system built for profit keep the biggest American problems off the table.
1:47:18ENLex Fridman· Jun 27, 2024Podcast · 2 speakersA Cannabis Clip Sat Quiet for a Year. Then It Hit X.Guest Andrew Huberman · Host Lex FridmanAndrew Huberman talks with Lex Fridman about online pile-ons, still minds, sharks, ayahuasca, and the slow work of picking who you eat with.
2:28:37ENLex Fridman· Jul 6, 2023Podcast · 2 speakersThe Marshals Came for an Underground City. RFK Jr. Still Wants a President Who Can Say NoGuest Robert F. Kennedy Jr · Host Lex FridmanOn Independence Day 2023, Lex Fridman sat with Robert F. Kennedy Jr. for two and a half hours on Cuba, Ukraine, the CIA, pharma, and why the shopping cart still has to go back.
3:15:07ENLex Fridman· Jun 18, 2023Podcast · 2 speakersWikipedia Worked Once Writing Stopped Feeling Like Grad SchoolGuest Jimmy Wales · Host Lex FridmanJimmy Wales tells Lex Fridman how Nupedia's seven-stage review died, why Wikipedia still refuses ads and governments, and what large language models should actually do with an encyclopedia.
4:27:46ENLex Fridman· Mar 14, 2023Podcast · 2 speakersHalf a Million Girls in Wells, and We Still Change the ChannelGuest Sam Harris · Host Lex FridmanSam Harris tells Lex Fridman why emotional contagion is a bad moral compass, why Trump broke norms more than laws, and why Twitter, COVID, and AGI all look like failures of seriousness.
4:11:06ENLex Fridman· Nov 18, 2022PodcastThe climate problem is real. The 12-year asteroid story is not.Host Lex FridmanBjørn Lomborg and Andrew Revkin tell Lex Fridman why vulnerability, cheaper tons of carbon, and energy innovation matter more than apocalyptic deadlines.
2:43:51ENLex Fridman· Jun 25, 2022Podcast · 2 speakersTwo Tubes, Millimeters Apart: Jonathan Reisman on the Honest Design of the Human BodyGuest Jonathan Reisman · Host Lex FridmanThe emergency physician and author of The Unseen Body walks Lex Fridman from the throat to the Arctic, arguing that anatomy is mostly brilliant, sometimes a near-miss, and always a story written in scars.
1:42:06ENLex Fridman· Jun 4, 2022Podcast · 2 speakersJonathan Haidt: Instagram Is Not 'Generally Positive' for Teen MindsGuest Jonathan Haidt · Host Lex FridmanThe NYU social psychologist answers Mark Zuckerberg on adolescent mental health and argues that one business model rewired childhood and then the public square.
2:55:05ENLex Fridman· May 8, 2022Podcast · 2 speakersExtinction awareness is the human trait Mason wants to carry to the starsGuest Chris Mason · Host Lex FridmanCornell geneticist Chris Mason on why seeing our own end creates a duty to engineer life for other worlds — and what a 500-year plan would actually require.
2:29:08ENLex Fridman· Apr 20, 2022Podcast · 2 speakersStarvation Is a Weapon. Skye Fitzgerald Still Puts the Camera Down.Guest Skye Fitzgerald · Host Lex FridmanNearly 811 million people are hungry today, and 45 million stand at the edge of famine across 43 countries — while the food to feed them already exists.
2:49:41ENLex Fridman· Mar 5, 2022Podcast · 2 speakersNazi Science Was Not Anti-Science. It Was Science with a Purity QuestGuest Robert Proctor · Host Lex FridmanStanford historian Robert Proctor on how ideology, tobacco, and the taxonomic impulse turn scientists into widget-builders.
2:17:29ENLex Fridman· Feb 11, 2022Podcast · 2 speakersThe knowledge doctors trust is built to sell drugsGuest John Abramson · Host Lex FridmanHarvard physician John Abramson tells Lex Fridman how pharmaceutical companies captured medical knowledge, and why American healthcare spends more while delivering less.
2:21:49ENLex Fridman· Jan 4, 2022Podcast · 2 speakersFocused Protection, Not Lockdowns: Jay Bhattacharya on What Public Health Got WrongGuest Jay Bhattacharya · Host Lex FridmanThe Stanford physician and co-author of the Great Barrington Declaration tells Lex Fridman why age-stratified risk, seroprevalence data, and the ignored costs of isolation pointed to a different COVID strategy.
1:08:04ENLex Fridman· Dec 18, 2021Podcast · 2 speakersBreakthroughs Run on Speed. Trust Runs on Patience.Guest Albert Bourla · Host Lex FridmanPfizer CEO Albert Bourla talks with Lex Fridman about the November 2020 unblinding, a $2.3 billion all-in bet, and why a historic vaccine still divided the public.
4:55:09ENLex Fridman· Dec 8, 2021Podcast · 2 speakersJamie Metzl Puts the Lab-Leak Odds at 85 PercentGuest Jamie Metzl · Host Lex FridmanThe genetic-engineering author walks Lex Fridman through the circumstantial case for a Wuhan accident, the cover-up he says is no longer debatable, and why the next pandemic will be decided by transparency, not blame.
1:26:53ENLex Fridman· Nov 5, 2021Podcast · 2 speakersFrancis Collins Cannot Exclude a Lab LeakGuest Francis Collins · Host Lex FridmanThe outgoing NIH director talks with Lex Fridman about COVID origins, gain-of-function research, Anthony Fauci, vaccines, and why scientific certainty is the wrong pose.
1:46:47ENLex Fridman· Oct 29, 2021Podcast · 2 speakersA Perfect Rapid Test Would Fail the FDA. Michael Mina Explains Why That Is the PointGuest Michael Mina · Host Lex FridmanThe Harvard immunologist tells Lex Fridman that paper-strip antigen tests answer the only public-health question that matters—are you infectious right now—and that one presidential sentence could unlock them.
1:11:03ENLex Fridman· Oct 23, 2021Podcast · 2 speakersCarl Hart’s case that addiction lives outside the moleculeGuest Carl Hart · Host Lex FridmanThe Columbia psychologist tells Lex Fridman that most drug effects are positive, that alcohol withdrawal is deadlier than heroin’s, and that the war on drugs pays a long list of people to keep a scapegoat in place.Load moreShowing 24 of 43