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1:48:29ENHow AI Is Changing Programming: John Crepezzi and Ron MinskyYaron Minsky, John Crepezzi · Jane StreetJane Street’s AI tooling lead and the Signals and Threads host examine agent infrastructure, security, code review and the changing experience of writing software.
1:36:37ENAaron Bauer on Teaching Software Engineering in the Age of AIYaron Minsky, Aaron Bauer · Jane StreetHow learning goals, active practice and editor design shape engineering education when models can generate the code.
1:04:35ENCliff Weitzman on Owning GPUs, Voice AI and Building SpeechifyGuest Cliff Weitzman · Host Harry StebbingsSpeechify's CEO makes the case for owning part of a compute fleet, reflects on a missed business-software opportunity and discusses AI-assisted teams.
5:15:51ENDHH Did Not Write a Line of Omarchy QuattroGuest DHH · Host Lex FridmanThirteen months after a skeptical conversation with Lex Fridman, the Rails creator describes how Opus 4.5, a swarm of coding agents, and a one-minute Linux installer ended his era of hand-chiseled Ruby.
27:19ENThe Turing Test Passed. Warp's CEO Says Nobody Seemed to CareHost Sarah Guo, Elad GilZach Lloyd on distilling intelligence without consciousness, why a 40-year-old terminal is the front door for coding agents, and why senior engineers just got more expensive.
1:12:58ENChris Lattner on Mojo and the Search for Portable GPU PerformanceYaron Minsky, Chris Lattner · Jane StreetRon Minsky and Chris Lattner discuss the language and compiler design behind Modular’s effort to make accelerator programming both portable and fast.
1:16:25ENMartin Casado on AI Models, Open Technology and Venture CompetitionGuest Martin Casado · Host Harry StebbingsThe Andreessen Horowitz partner discusses coding tools, open-model policy, labor disruption and how his firm evaluates investments.
6:08:48ENNobody Serious Believes Cookie Banners Help AnyoneGuest DHH · Host Lex FridmanLex Fridman talks with David Heinemeier Hansson for six hours about Ruby, Rails, AI, leaving the cloud, Apple's App Store, and why a small company can still refuse other people's money.
44:44EN$1 of R&D, 35x the return: why Parker Conrad says platforms beat point solutionsHost Sarah Guo, Elad GilThe Rippling CEO on Zenefits, founder psychology, and why shared underlying capabilities—not narrow focus—win in enterprise software.
1:04:56ENVarun Mohan on Windsurf, Coding Agents and Startup FocusGuest Varun Mohan · Host Harry StebbingsThe Windsurf co-founder discusses pivots, rapid product experimentation, coding agents and competition among AI model providers.
5:20:08ENThePrimeagen Would Rather Redesign the Room Than Trust WillpowerGuest ThePrimeagen · Host Lex FridmanLex Fridman talks with Michael Paulson about linked lists, Netflix, Neovim, ADHD, addiction, AI, and the night he says God gave him a conscience.
59:46ENIn Young Cho on Trading Research and Finding Signal in Financial DataYaron Minsky, In Young Cho · Jane StreetIn Young Cho and Ron Minsky discuss the blurred lines between trading, research, and engineering, and why machine learning in markets is difficult.
38:05ENFrom Zero to $20M ARR in Two Months: Bolt's Moat Lives in the BrowserHost Sarah Guo, Elad GilStackBlitz CEO Eric Simons tells No Priors how a five-year WebContainers bet, an open-sourced prompt, and a community of non-coders turned Bolt.new into an overnight full-stack generator.
40:33ENCharlie Marsh on uv: Python Dependency Resolution and PerformanceCharlie Marsh · AstralThe Astral founder explains universal lockfiles, Python packaging constraints, and the data structures and cache design behind uv.
1:03:36ENErin Murphy on Designing Tools for Expert UsersYaron Minsky, Erin Murphy · Jane StreetFrom NASA scientists to Jane Street engineers, a UX designer explains how observation, drawing and collaboration reveal what complex tools need to do.
29:28ENDevin Will Not Replace Engineers. It Will Multiply Them, Says Cognition’s Scott WuHost Sarah Guo, Elad GilThe IOI champion behind Devin explains why an AI software engineer that you can watch over the shoulder creates more human engineers, not fewer.
55:34ENAndrew Hunter on Performance Engineering for Low-Latency SystemsYaron Minsky, Andrew Hunter · Jane StreetWhy small optimizations pay at hyperscale, why trading latency is harder to measure, and how profiling, tracing, language design and hardware fit together.
32:34ENTen Thousand Certified Engineers in a Year: Google Cloud's Order of Operations for Enterprise AIHost Sarah Guo, Elad GilKawal Gandhi, head of generative AI in Google Cloud's Office of the CTO, walks Sarah Guo and Elad Gil through dogfooding, the efficiency-productivity-creativity ladder, and why customer weights are the IP that cannot leak.
29:38ENA Beginner Just Shipped a $250K Business. Professionals Got 30 Percent.Host Sarah Guo, Elad GilReplit CEO Amjad Masad on Ghostwriter, why a 3-billion-parameter model was enough, and the agents he wants earning bounties while you sleep.
38:13ENChatGPT Runs on His Framework. He Still Doesn't Want You Training a ModelHost Sarah Guo, Elad GilVercel founder Guillermo Rauch tells No Priors why frontend is the last mile of AI, why first-generation AI frameworks will be rewritten, and why bots are already stealing your tokens.
1:02:17ENPeter Bogart-Johnson on Product Management, Poetry and ListeningYaron Minsky, Peter Bogart-Johnson · Jane StreetA poet and program manager explains how to earn a team’s trust, preserve what works and coordinate change without separating engineers from their users.
44:19ENAI Will Write Ten Times More Code. Someone Still Has to Keep It Running.Host Sarah Guo, Elad GilDatadog co-founder Olivier Pomel on why faster generation moves value from writing software to understanding, securing, and operating it.
41:40ENEvery 10 Milliseconds Cost Copilot 1% of CompletionsHost Sarah Guo, Elad GilGitHub Copilot's chief architect, Alex Graveley, walks through how a leftover code model with a sub-10% test pass rate became a product developers would not quit — and what he is building next at Minion AI.
3:15:51ENPython Is a Recipe Written for Two ReadersGuest Guido van Rossum · Host Lex FridmanGuido van Rossum on CPython’s 3.11 speedups, indentation, the GIL, and why a 4.0 would hurt extensions more than syntax.
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