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31:39ENThe Skull Is Already the Vat: Max Hodak on Restoring SightHost Sarah Guo, Elad GilPatients blinded by macular degeneration put on laser-projector glasses, read books, and fill in Sudoku — because a chip under the retina is sending vision back into the brain.
2:59:44ENTwo Endangered Languages Broke Transformers. Nested Learning Gave Models a Sleep Button.Host Nathan LabenzGoogle researcher Ali Behrouz tells Nathan Labenz how stacking update frequencies — not just layers — and an offline sleep phase could give language models genuine continual learning.
3:18:09ENA Thing Is Alive When Its Goals Outrun Its PartsGuest Michael Levin · Host Lex FridmanTufts biologist Michael Levin tells Lex Fridman that intelligence is a spectrum of persuadability, that even a bubble sort hosts unexpected goals, and that the brain is a thin client to a space physics does not own.
2:42:06ENThe word 'evil' ends the conversationGuest Julia Shaw · Host Lex FridmanCriminal psychologist Julia Shaw talks with Lex Fridman about the dark tetrad, serial killers, jealousy, bisexuality, and why generative AI is the ultimate false-memory machine.
1:13:23ENAn AI Found a GABA-Cancer Link. The Next Step Is Talking to the Cells.Host Nathan LabenzMichael Levin and Leo Pio Lopez on a multilayer embedding that predicted melanoma, a cancer with no mutations, and why biology's real interface is cognitive.
1:59:47ENBCI Would Take 30 Years. This Studio Pivoted to Alignment InsteadHost Nathan LabenzJudd Rosenblatt and Mike Vaiana of AE Studio describe two biologically inspired results that do not need interpretability breakthroughs to work.
8:37:34ENThe first Neuralink patient beat a world record with most of his electrodes goneGuest Elon Musk · Host Lex FridmanLex Fridman talks with Elon Musk, the Neuralink team, and Noland Arbaugh about a wireless brain implant, the software that rescued it, and why bandwidth is Musk’s bet on living with AI.
1:47:18ENA Cannabis Clip Sat Quiet for a Year. Then It Hit X.Guest Andrew Huberman · Host Lex FridmanAndrew Huberman talks with Lex Fridman about online pile-ons, still minds, sharks, ayahuasca, and the slow work of picking who you eat with.
3:10:49ENMemory Is Not a Replay: Charan Ranganath on Forgetting, Imagination, and False MemoriesGuest Charan Ranganath · Host Lex FridmanA UC Davis neuroscientist explains why the brain is a cheap prediction machine — and why forgetting is how memory works.
1:29:14EN55% of People Have Had a Lucid Dream. Prophetic AI Wants the Rest to Have One Every NightHost Nathan LabenzProphetic AI co-founders Eric Wollberg and Wesley Berry tell Ate-a-Pi how a headband of EEG and focused ultrasound, steered by a neural transformer, is meant to light up the prefrontal cortex during REM.
2:09:50ENHe stayed up all night playing Civilization 6 with his mindHost Nathan LabenzDean W. Ball surveys EEG, ultrasound stimulation, and Neuralink with Nathan Labenz, and argues that merging with machines started decades ago.
2:50:44ENThe Pirahã Have No Word for OneGuest Edward Gibson · Host Lex FridmanMIT psycholinguist Ted Gibson tells Lex Fridman why related words sit together, why language is not thought, and why large language models ace form while missing meaning.
1:34:11ENFrom forty hours in a scanner to one: reconstructing what you see from a shared brain spaceHost Nathan LabenzPaul Scotti explains how MindEye2 maps a new person's fMRI into CLIP with an hour of data, and why a linear layer plus better image generators changed the cost of reading minds.
1:25:09ENTwo-Headed Worms, Regenerated Legs, and a Sort That Learned to WaitHost Nathan LabenzTufts biologist Michael Levin tells Cognitive Revolution why anatomy is rewritable software, and why he stopped a paper that might have made AI more alive.
1:58:43ENA Worm With 302 Neurons Already Makes Trade-offs. AI Is Still on the Same Ladder.Host Nathan LabenzMax Bennett maps 600 million years of brain evolution onto five breakthroughs — and asks which rungs today's models have actually reached.
1:18:18ENFifteen Thousand Brain Numbers Were Enough to Reconstruct What Someone SawHost Nathan LabenzTanishq Mathew Abraham walks through MindEye, the fMRI-to-image system that maps a handful of voxel values onto CLIP and diffusion models.
2:30:28ENAI Only Has a Neocortex: Manolis Kellis on Evolutionary Baggage and Superintelligent PartnersGuest Manolis Kellis · Host Lex FridmanOn his fifth Lex Fridman podcast, the MIT computational biologist argues that layered evolutionary history is what makes humans irreplaceable — and that alignment with AI has to run both ways.
2:39:40ENThe Self That Swoops In to Decide Is Not ThereGuest Annaka Harris · Host Lex FridmanAnnaka Harris tells Lex Fridman why conscious will is an illusion, why a pea tendril is a better picture of choice than an inner agent, and why she now treats consciousness as a possible fundamental of physics.
2:44:16ENIQ at Eleven Predicted Survival at Eighty. Richard Haier on the Finding Psychology Tried to BuryGuest Richard Haier · Host Lex FridmanLex Fridman talks with psychologist Richard Haier about the g factor, The Bell Curve, group differences, and why intelligence research became the most radioactive topic in the field.
3:21:29ENWhen something in the mind breaks, you see what it was forGuest Karl Deisseroth · Host Lex FridmanStanford psychiatrist Karl Deisseroth talks with Lex Fridman about depression, schizophrenia, optogenetics, and why you can treat one symptom without a theory of everything.
2:37:03ENNo One Knows How to Make a PencilGuest Tim Urban · Host Lex FridmanWait But Why's Tim Urban spent five years on a book about why society is tearing itself apart, then sat down with Lex Fridman to talk aliens, Musk, Neuralink, and the war inside a procrastinator's head.
1:42:58ENDon't Talk Conclusions. Talk Data.Guest Garry Nolan · Host Lex FridmanA Stanford immunologist sat through the brain scans of people who said they had met UFOs—and treats the rest of the subject the same way.
2:46:31ENThe Official Scientific Worldview Is Incompatible With ConsciousnessGuest Philip Goff · Host Lex FridmanDurham philosopher Philip Goff tells Lex Fridman why panpsychism — the view that consciousness is fundamental and ubiquitous — is the least-bad theory of mind.
2:56:42ENSilicon Does Not Emit LightGuest Jeffrey Shainline · Host Lex FridmanNIST physicist Jeffrey Shainline on why a brain-like computer should calculate in superconducting electronics and talk with single photons.
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