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1:09:44EN
No Priors: AI, Machine Learning, Tech, & Startups· Oct 9, 2026Podcast · 2 speakers10,000 GB300s for Four Weeks: Reflection’s Open-Model LedgerHost Sarah Guo, Elad GilMisha Laskin tells No Priors how Reflection trained Beam, why reinforcement learning outspent pre-training, and why the West needs its own open weights.
5:15:51EN
Lex Fridman· Aug 26, 2026Podcast · 2 speakersDHH Did Not Write a Line of Omarchy QuattroGuest DHH · Host Lex FridmanThirteen months after a skeptical conversation with Lex Fridman, the Rails creator describes how Opus 4.5, a swarm of coding agents, and a one-minute Linux installer ended his era of hand-chiseled Ruby.
4:18:22ENLex Fridman· May 6, 2026Podcast · 2 speakersEvery Cycle Matters: The Volunteers Who Decode Almost All Internet VideoGuest FFmpeg · Host Lex FridmanLex Fridman talks with Jean-Baptiste Kempf and Kieran Kunhya about FFmpeg, VLC, handwritten assembly, and the unpaid crew behind YouTube, Netflix, and a rover on Mars.
3:15:52ENLex Fridman· Feb 11, 2026Podcast · 2 speakersThe Voice Note His Bot Couldn't Handle — and the Agent That Built Itself AnywayGuest OpenClaw · Host Lex FridmanPeter Steinberger tells Lex Fridman how a one-hour WhatsApp toy became GitHub's fastest-growing project, and what it cost him to keep it open.
40:54ENNo Priors: AI, Machine Learning, Tech, & Startups· Aug 28, 2025Podcast · 2 speakersSeventeen Years of Flat Power, and a Plan to Bring the Factories HomeHost Sarah Guo, Elad GilJacob Helberg, the under secretary of state designate for economic growth, energy, and the environment, argues that nuclear power and AI productivity—not cheap labor—are how America reshore its supply chain.
47:18ENNo Priors: AI, Machine Learning, Tech, & Startups· Aug 14, 2025Podcast · 2 speakersThe Analyst Tracking 200 GPU Clouds Breaks Nvidia Into a Three-Headed DragonHost Sarah Guo, Elad GilSemiAnalysis founder Dylan Patel on OpenAI’s open-weight model, a coming neocloud wipeout, and why a chip startup has to beat Nvidia on hardware, networking, and software at once.
36:48ENNo Priors: AI, Machine Learning, Tech, & Startups· Jul 31, 2025Podcast · 2 speakersThe Weekend DeepSeek Dropped, the White House CalledHost Sarah Guo, Elad GilSriram Krishnan walks No Priors through America’s 28-page AI Action Plan, a token-share definition of winning, and why the lead over China is too small to take for granted.
35:14ENNo Priors: AI, Machine Learning, Tech, & Startups· Mar 20, 2025Podcast · 2 speakersRobots Have No Wikipedia. Chelsea Finn Is Starting With Three Buildings.Host Sarah Guo, Elad GilPhysical Intelligence’s cofounder tells No Priors why a generalist robot model has to be trained across embodiments, why open-sourcing hardware is a bet against the problem going unsolved, and why humanoids are a little overrated.
57:41ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 25, 2025Podcast · 2 speakersA Hundred Million Cells, Four People, Three Days: Biology's ImageNet MomentHost Sarah Guo, Elad GilVevo Therapeutics and the Arc Institute open-sourced Tahoe-100M and a 230-million-cell atlas in the same week — and argued that virtual cells, not just protein folders, are the next language model of biology.
38:05ENNo Priors: AI, Machine Learning, Tech, & Startups· Dec 5, 2024Podcast · 2 speakersFrom Zero to $20M ARR in Two Months: Bolt's Moat Lives in the BrowserHost Sarah Guo, Elad GilStackBlitz CEO Eric Simons tells No Priors how a five-year WebContainers bet, an open-sourced prompt, and a community of non-coders turned Bolt.new into an overnight full-stack generator.
42:59ENNo Priors: AI, Machine Learning, Tech, & Startups· Aug 29, 2024Podcast · 2 speakersAWS Is a $100 Billion Cloud. Matt Garman Still Sees a 10x Migration AheadHost Sarah Guo, Elad GilAmazon Web Services’ new CEO tells No Priors why 85 percent of workloads are still on-prem, how Bedrock was built from three bets, and why startups remain the company’s growth engine.
39:03ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 29, 2024Podcast · 2 speakersMI300 Leads Inference by 2x: AMD's CTO on Winning Chip Competition Without a Walled GardenHost Sarah Guo, Elad GilWhen Mark Papermaster became AMD's CTO in fall 2011, nearly all of the company's revenue sat on PCs and gaming, Moore's Law was slowing, and everyone knew it needed a turnaround.
39:36ENNo Priors: AI, Machine Learning, Tech, & Startups· Dec 14, 2023Podcast · 2 speakersThe Most Underestimated AI Buyer Is the Shop on the CornerHost Sarah Guo, Elad GilFormer Square CEO Alyssa Henry tells No Priors that generative AI is unlocking work small merchants always needed and never paid anyone to do.
32:57ENNo Priors: AI, Machine Learning, Tech, & Startups· Nov 9, 2023Podcast · 2 speakersA 7-billion-parameter model on a MacBook: Mistral's CEO reruns the cost of AIHost Sarah Guo, Elad GilArthur Mensch tells No Priors why Chinchilla made small models valuable, why open-sourcing Mistral 7B is not a bioweapon risk, and why guardrails belong on the application.
3:08:46ENLex Fridman· Jun 29, 2023Podcast · 2 speakersWho owns the off switch? George Hotz on tinygrad, open-source AI, and GodGuest George Hotz · Host Lex FridmanOn his third Lex Fridman podcast, the comma.ai and tiny corp founder argues that compute, intelligence, and the off switch should live in people's houses, not in a trusted few.
3:15:07ENLex Fridman· Jun 18, 2023Podcast · 2 speakersWikipedia Worked Once Writing Stopped Feeling Like Grad SchoolGuest Jimmy Wales · Host Lex FridmanJimmy Wales tells Lex Fridman how Nupedia's seven-stage review died, why Wikipedia still refuses ads and governments, and what large language models should actually do with an encyclopedia.
2:41:58ENLex Fridman· Jun 8, 2023Podcast · 2 speakersZuckerberg showed up as Mark Elliott — then argued for many AIs, not oneGuest Mark Zuckerberg · Host Lex FridmanOn his second Lex Fridman podcast, the Meta CEO treats a disguised first jiu-jitsu tournament, an open research model called LLaMA, and a future of many agents as the same bet: ship before it is perfect, and do not build a single god model.
2:07:04ENLex Fridman· May 28, 2023Podcast · 2 speakersThe Ribosome Already Solved Digital ManufacturingGuest Neil Gershenfeld · Host Lex FridmanNeil Gershenfeld tells Lex Fridman why Turing separated the head from the tape, how fab labs are the personal-computer moment for making things, and what it would take to grow a civilization from about twenty parts.
37:26ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 23, 2023Podcast · 2 speakersWithout Open Source, Machine Learning Would Be Decades BehindHost Sarah Guo, Elad GilHugging Face CEO Clem Delangue on the Tamagotchi pivot, why the company never hired a community manager, and why he does not believe one model will rule them all.
45:03ENNo Priors: AI, Machine Learning, Tech, & Startups· Feb 16, 2023Podcast · 2 speakersEmad Mostaque’s bet: open small models, not one giant brainHost Sarah Guo, Elad GilStability AI’s founder tells No Priors why foundation models should be public infrastructure, why small models can beat giant ones, and what that means for media, medicine, and AGI.
3:15:51ENLex Fridman· Nov 26, 2022Podcast · 2 speakersPython Is a Recipe Written for Two ReadersGuest Guido van Rossum · Host Lex FridmanGuido van Rossum on CPython’s 3.11 speedups, indentation, the GIL, and why a 4.0 would hurt extensions more than syntax.
5:14:50ENLex Fridman· Aug 4, 2022Podcast · 2 speakersThe best programming language is the one you already useGuest John Carmack · Host Lex FridmanJohn Carmack talks with Lex Fridman about languages, id Software, VR, rockets, and why AGI might be tens of thousands of lines of code.
2:10:08ENLex Fridman· Jul 26, 2022Podcast · 2 speakersGato Is Only the BeginningGuest Oriol Vinyals · Host Lex FridmanDeepMind's Oriol Vinyals talks with Lex Fridman about generalist agents, thrown-away weights, and whether human-level AGI arrives in his lifetime.
2:46:40ENLex Fridman· Dec 23, 2021Podcast · 2 speakersThe Tools That Fit in a Head Were Built by People Who Fit in a VanGuest Peter Wang · Host Lex FridmanAnaconda's Peter Wang talks with Lex Fridman about Python, cybernetic systems, and why sharing software creates value that scarcity economics still cannot price.Load moreShowing 24 of 50