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1:22:31ENPower Is a Tool: Stanford's Jeffrey Pfeffer on the Seven Rules of Getting AheadGuest Jeffrey Pfeffer · Host Lenny RachitskyStanford organizational behavior professor Jeffrey Pfeffer walks Lenny Rachitsky through the seven rules of power, the homework that makes them stick, and the price power exacts.
1:45:55ENFrom Static Structures to Moving Molecules: Where AI for Protein Design Stands After AlphaFold 3Host Nathan LabenzComputational biochemist Amelie Schreiber walks Nathan Labenz through six months of progress in structure prediction, molecular dynamics, peptide and antibody models, and early agent-driven design workflows.
46:21ENForty-Eight Miles, Twelve Thank-Yous: Lex Fridman Takes On the Goggins ChallengeHost Lex FridmanLex Fridman runs four miles every four hours for 48 hours and records a gratitude reflection after each session.
1:17:25ENDon't Trust the Process: How Design Work Is Being Rebuilt Around Engineers and AgentsHost Lenny RachitskyClaude Cowork design lead Jenny Wen explains why the classic discovery-to-mock workflow is fading, what designers do instead, and who she wants to hire.
1:47:31ENFrom Fever Dream to Wilderness: Drew Houston on Dropbox's Three ErasGuest Drew Houston · Host Lenny RachitskyDropbox's co-founder and CEO gives a candid account of explosive growth, the Google Photos shock, a painful pivot to productivity, and the personal and organizational reset that followed.
40:42ENDon't Mistake a Month of Hype for the End of SoftwareHost Sarah Guo, Elad GilSarah Guo and Elad Gil separate the SaaS-apocalypse noise from the real signals: record revenue ramps, collapsing token prices, and the question of when a founder should sell.
34:57ENIt's Six Months In: Misconceptions About AI, Regulation, Context Windows and IncumbentsHost Sarah Guo, Elad GilSarah Guo and Elad Gil answer listener questions on what the market gets wrong about generative AI, from the nuclear-regulation analogy to where startups can still beat incumbents.
2:01:57ENBuild the Sales Team Like a Founder: Jason Lemkin on Hiring, Comp and Keeping Product CloseGuest Jason Lemkin · Host Lenny RachitskySaaStr founder Jason Lemkin walks through when to hire your first reps, who to hire, how to pay them, how product and sales should work together, and why customer-hostile tactics don't compound.
1:37:47ENYou Can Patch a Bug, but You Can't Patch a Brain: Why AI Guardrails FailGuest Sander Schulhoff · Host Lenny RachitskyAdversarial-robustness researcher Sander Schulhoff explains why prompt injection and jailbreaks remain unsolved, why guardrail products don't deliver, and what teams can do instead.
2:53:45ENJoscha Bach on Seven Stages of Lucidity, Brutalist LLMs, and Why Life on Earth Isn't Only About HumansGuest Joscha Bach · Host Lex FridmanA wide-ranging conversation on how minds are built, what language models are missing, and how an AI-saturated world might change consciousness, identity and risk.
17:40ENFrom AlphaGo Zero to MuZero: How Self-Play Strips Knowledge Out of AIHost Lex FridmanDeepMind's David Silver explains why removing human knowledge made AlphaZero stronger and more general, and how MuZero extended the idea to worlds with unknown rules.
53:39ENA Libertarian's Case for Regulating AI: Kill Switches, Chip Choke Points and a New Form of LifeHost Nathan LabenzLindy founder Flo Crivello explains why a self-described accelerationist makes an exception for superintelligence, and what he thinks of Biden's executive order.
1:18:22ENShipyards, Sharp Problems and Humility: Two Veteran Product Leaders on the PM Role in the AI EraHost Lenny RachitskyOji and Ezinne Udezue explain how product management is changing, which skills matter now, and what the companies winning with AI do differently.
1:41:44ENZig When Others Zag: HubSpot Co-founder Dharmesh Shah on Simplicity, Culture as a Product and Building a Company Around Your StrengthsGuest Dharmesh Shah · Host Lenny RachitskyThe HubSpot co-founder and CTO explains why he has never had a direct report, how he measures laughs per minute, and the first-principles habits behind HubSpot's contrarian choices.
23:57ENChips, Agents and a Reckoning: Sarah Guo and Elad Gil on the 2023 AI BoomHost Sarah Guo, Elad GilThe hosts answer listener questions on the GPU crunch, how soon enterprises will ship AI products, how to build agents, and what 2024 holds for tech valuations.
1:02:49ENStop Being the Arrogant Doctor: Andy Raskin on Pitching a Movement, Not a ProductGuest Andy Raskin · Host Lenny RachitskyStrategic narrative consultant Andy Raskin explains the five-part story structure behind pitches at Salesforce, Zuora and Gong, and how to make it your company's north star.
44:30ENOpen the Front Door: Emil Michael on Rebuilding U.S. Defense Around Startups, AI and Supply ChainsHost Sarah Guo, Elad GilThe Pentagon's research and engineering chief explains his six technology priorities, the rapid launch of GenAI.mil, and why new entrants and domestic manufacturing are now urgent.
1:10:32ENA Billion Dollars, No VC, Under 100 People: Surge AI's Edwin Chen on Data Quality and Where AI Is HeadingGuest Edwin Chen · Host Lenny RachitskySurge AI's founder explains how a bootstrapped team built the leading human-data company, why he distrusts benchmarks, and how reinforcement learning environments are the next frontier.
1:07:22ENCars That Drive Empty: Emilio Frazzoli on Why Self-Driving Needs Rules, Not Just DataHost Lex FridmanThe nuTonomy CTO explains why full autonomy and shared fleets are where the value lies, and why the hardest open problem is deciding how vehicles should behave.
1:16:17ENFaster, But for What? Nicole Forsgren on Measuring Developer Productivity in the AI EraGuest Nicole Forsgren · Host Lenny RachitskyThe creator of DORA and SPACE explains why most productivity metrics mislead, how AI changes flow and trust, and how to build a developer experience program that proves its value.
1:04:21ENOnboarding Is Growth's Biggest Lever: Lessons from Airtable's Former Head of GrowthGuest Lauryn Isford · Host Lenny RachitskyLauryn Isford on rethinking experimentation, choosing a hard-to-reach activation metric, reverse trials, and the PLG funnel.
1:49:39ENNo Investors, 24 Profitable Years: Jason Fried on Staying Small, Trusting Your Gut and Making Money FirstGuest Jason Fried · Host Lenny RachitskyThe 37signals co-founder explains how a 75-person, investor-free company has out-earned far larger rivals, and why he builds products in two-person, six-week cycles.
1:35:39ENMake Time: Pick a Daily Highlight and Build Barriers Against DistractionGuest Jake Knapp, John Zeratsky · Host Lenny RachitskyJake Knapp and John Zeratsky walk through their four-step Make Time framework (highlight, laser, energize, reflect) and close with a short look at the design sprint.
1:34:57ENFifteen People, Four Products, Zero Handwritten Code: Inside Every's AI-First CompanyGuest Dan Shipper · Host Lenny RachitskyEvery CEO Dan Shipper explains how his small team uses Claude Code, an AI operations lead and compounding engineering to do the work of a much larger company.
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