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18:13ENSid Pednekar: Judgment Is the Scarce Resource in AI AdoptionSid PednekarA framework for choosing valuable problems, building shared capabilities and turning experience into organizational learning.
14:04ENFrank Long on Building AI Investment Workflows Around QualityFrank Long · CoatueCoatue’s Frank Long breaks investing into information, analysis and decision steps, and argues for choosing the right combination of code, models and people.
50:50ENFabian Theis on Virtual Cells, Organoids and Closing the Lab LoopGuest Fabian Theis · Host RJ Honicky, Brandon AndersonThe Helmholtz Munich researcher explains perturbation models, biological benchmarks and the work required to connect prediction with experiments.
17:52ENCameron Wolfe on Evaluating AI When Answers Are SubjectiveCameron Wolfe · NetflixNetflix’s Cameron Wolfe outlines human review, calibrated model judges and production monitoring as a repeatable evaluation loop.
54:08ENVlad Tenev on Ownership, Tokenization and AI TradingGuest Vlad Tenev · Host Sarah GuoRobinhood’s CEO discusses his vision for wider asset ownership, mathematical AI and agentic finance with Sarah Guo.
42:06ENData-Center Power, Financing and Compute: A Panel with Yixing Xu, Alex Yeh and Bruce LiuGuest Yixing Xu, Alex Yeh, Bruce Liu · Host Christina XuBuilders and an investor discuss transmission constraints, delivery delays, lease mismatches and the economics of selling compute.
1:19:29ENScaling Slack and GitHub: Maude Lemaire on Load, Shards and Reliable PlatformsGuest Maude Lemaire · Host Gergely OroszThe principal engineer explains a Slack data migration, realistic load testing, GitHub’s shard constraints and her approach to AI-assisted performance work.
41:02ENTheo on PewDiePie’s Local AI Project, Training Data and Model SafetyTheo, PewDiePieA reaction to the Ajax and Odysius project becomes a discussion of opt-in data, agent traces, fine-tuning and local model tradeoffs.
20:45ENJohn Stecher and Scott Worland on Building AI Systems That Can ChangeScott Worland, John Stecher · Norm AIThe Blackstone and Norm AI CTOs discuss data strategy, evaluations, production controls and when to wait for a better model.
23:55ENSusan Wojcicki’s Family on Her Life and Lung-Cancer ResearchGuest Dennis Troper, Esther Wojcicki, Anne Wojcicki, Janet Wojcicki · Host Marina MogilkoHer family remembers her priorities as a mother and leader and discusses the foundation’s goals for research and earlier detection.
1:01:05ENDiogo Almeida on Decision Models, Benchmark Fatigue and Agent ReliabilityGuest Diogo Almeida · Host Jacob EffronThe creator of Jev discusses structured decisions, model evaluation and the practical problems of building with AI agents.
2:16:39ENGregory Forth on Flores Fossils and Reports of Humanlike BeingsGuest Gregory Forth · Host Joe RoganThe anthropologist discusses fieldwork, local traditions and a disputed hypothesis about a surviving hominin.
52:36ENKim Maida and Mason Egger: Secure Agent Access and Durable ExecutionKim Maida, Mason Egger · KeycardAn expense-approval workshop combines per-call OAuth token exchange with Temporal workflows that recover after a worker fails.
42:40ENDaniel Terhorst-North: Use Generative AI to Go Broader, Not Just FasterDaniel Terhorst-North · Dan North & AssociatesA software practitioner shares how an AI-assisted teaching toolkit led him to “adjacent engineering,” larger test-first steps and external guardrails.
1:43:54ENJoshua Monrad on AI, Biosecurity and Building Layers of DefenseGuest Joshua Monrad · Host Nathan LabenzSentinel Bio’s co-founder discusses uncertain AI-related biological risks, practical safeguards and the long work of global resilience.
15:32ENEmil Chetty on Letting Payment Agents Act Within Customer-Approved BoundariesEmil Chetty · WiseWise’s data and AI product lead describes an immutable job agreement that lets agents choose steps while trusted payment services enforce customer authorization.
39:31ENThariq Shihipar on Closing a Startup and Leaving AnthropicGuest Thariq Shihipar · Host Sarah Chieng, Vivian Midha ShenThe former Claude Code engineer joins SOTA Wives to discuss fundraising, AI labs, content and the social world around technology.
22:01ENReid Hoffman on the Midterms, Political Donations and Tech’s Public ResponsibilitiesHost Aria Finger, Reid HoffmanHoffman and Aria Finger discuss their interpretation of Democratic gains, campaign finance and the bargain between data centers and communities.
1:11:45ENDavid Geary on Conflict, Cooperation and Human EvolutionGuest David Geary · Host Chris WilliamsonAn evolutionary psychologist presents his account of group conflict, status and human cognition; several claims remain contested.
50:11ENHow Figma’s Finance Team Uses AI to Build and AutomateSeema Amble, Ivan Makarov, Praveer Melwani · Andreessen HorowitzCFO Praveer Melwani discusses finance workflows, human judgment, shared systems and the skills his team needs.
13:22ENHow Brainbase Improved a Competitor-Pricing Agent from 41% to 97%Milind Sunil Shah · BrainbaseMilind Sunil Shah describes an iterative workflow for collecting and evaluating competitor prices with a back-office agent.
32:01ENRonak Malde on Continual Learning from Real-World Agent TracesPat Grady, Lauren Reeder, Ronak Malde · Sequoia CapitalTrajectory’s co-founder explains its training platform, two research directions and his vision for adapting models to company-specific work.
18:14ENDwarkesh Patel: Testing AI Deception and Reasoning in Blood on the ClocktowerA 368-game social deception benchmark reveals elaborate AI schemes, improvements in evidence evaluation, and questions that remain open.
19:53ENAI News: Kimi K3.1 Weights, Computer Use and Specialized Open ModelsMatthew Berman · Forward FutureMatthew Berman reviews a week of model releases, from desktop agents and scientific workflows to image, video and speech tools.
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