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58:27EN
Sequoia Capital· Mar 24, 2026PodcastEven a dumber AI can win science if it never leaves the labGinkgo Bioworks CEO Jason Kelly tells Sequoia why autonomous labs, not smarter models, will change how experimental science gets done.
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Cognitive Revolution "How AI Changes Everything"· Mar 22, 2026PodcastGive an agent a thousand tools and it will pick the wrong bladeHost Nathan LabenzComposio CTO Karan Vaidya on the tool harness that discovers, authenticates, sandboxes, and rewrites integrations so agents can do whole jobs without drowning in context.
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No Priors: AI, Machine Learning, Tech, & Startups· Mar 20, 2026Podcast · 2 speakersAndrej Karpathy Hasn't Typed a Line of Code Since DecemberHost Sarah Guo, Elad GilOn No Priors, the OpenAI cofounder and former Tesla AI director describes the loopy era of coding agents, AutoResearch, and why the bottleneck is now the human.
40:56ENSequoia Capital· Mar 10, 2026PodcastFour of the Top Five Defense Primes Still Run Hardware Tests on PowerPointNominal’s cofounders argue that hardware never got the last twenty years of software infrastructure, and that physical AI will stall until test data lives in one place.
54:26ENCognitive Revolution "How AI Changes Everything"· Feb 22, 2026PodcastTen Billion Active Parameters, and the Unsexy Work of Making Them Agent-ReadyHost Nathan LabenzMiniMax researcher Olive Song explains how M2 was trained with expert developers as reward models, interleaved thinking, and a perturbation pipeline that treats every scaffold change as the real generalization test.
1:34:42ENCognitive Revolution "How AI Changes Everything"· Feb 13, 2026PodcastA $500 Kernel, a Ten-Month Village, and the Temper of AgentsHost Nathan LabenzJames Zou, Sam Hammond, and Shoshannah Tekofsky on science agents, America's knowledge-work bet, and what models actually do when you leave them alone.
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Lex Fridman· Feb 11, 2026Podcast · 2 speakersThe Voice Note His Bot Couldn't Handle — and the Agent That Built Itself AnywayGuest OpenClaw · Host Lex FridmanPeter Steinberger tells Lex Fridman how a one-hour WhatsApp toy became GitHub's fastest-growing project, and what it cost him to keep it open.
44:46ENSequoia Capital· Feb 10, 2026PodcastA Single Training Environment Can Cost Millions. Prime Intellect Wants a GitHub for RLWill Brown and Johannes Hagemann argue that the eval suite you already use to test agents is one step away from a training set.
1:18:49ENCognitive Revolution "How AI Changes Everything"· Feb 8, 2026PodcastIf AGI Is Cheap Intelligent Labor, Cyber Defense Should Become Continuous ForensicsHost Nathan LabenzAsymmetric Security founder Alexis Carlier argues that assuming AGI means redesigning defense around proactive digital forensics instead of alert triage.
51:56ENSequoia Capital· Feb 3, 2026PodcastInsurance Spends $70 Billion on BPOs. Pace Wants 80% Gross Margins InsteadJamie Cuffe tells Sequoia's Training Data how Pace is turning insurance back-office work into agentic process outsourcing—and why every one of its pilots has reached production.
48:03ENSequoia Capital· Jan 27, 2026PodcastCoding Will Be Solved. The Bottleneck Is Saying What You WantWarp founder Zach Lloyd tells Sequoia's Sonya Huang why a rebuilt terminal became the lucky form factor for coding agents, and why he stopped subsidizing tokens.
39:47ENSequoia Capital· Jan 21, 2026PodcastThe Context at Step 14 Isn't in the CodeLangChain cofounder Harrison Chase on why long-horizon agents finally work—and why traces, harnesses, and first-draft workflows matter more than scaffolding.
2:29:42ENCognitive Revolution "How AI Changes Everything"· Jan 18, 2026PodcastTwelve hooks and thirty files: Daniel Miessler’s personal OS on Claude CodeHost Nathan LabenzThe PAI framework treats scaffolding, not the model, as the product — a goal-centered agent stack that Miessler thinks will decide both knowledge-work automation and the next cybersecurity race.
1:40:51ENCognitive Revolution "How AI Changes Everything"· Jan 14, 2026PodcastReasoning Models Just Made the Other 80–90% of Enterprise Data UsableHost Nathan LabenzSnowflake VP of AI Baris Gultekin on text-to-SQL, RAG, agent design, and why inference has to run next to governed data.
41:38ENNo Priors: AI, Machine Learning, Tech, & Startups· Dec 11, 2025Podcast · 2 speakersElevenLabs Hit $300 Million ARR by Building Voice Before Anyone Believed It Was the InterfaceHost Sarah Guo, Elad GilIn Poland, watching a foreign film is a special kind of pain: one narrator, every character, a flat delivery from start to finish.
57:37EN
Unsupervised Learning: With Jacob Effron· Dec 10, 2025PodcastThe hot-swap era for models is over, OpenAI's enterprise product chief saysHost Jacob EffronOlivier Godement on GPT-5.1, Codex, enterprise harnesses, and the three practices that actually make AI land inside large companies.
42:06ENUnsupervised Learning: With Jacob Effron· Dec 2, 2025PodcastAfter SWE-bench Hits 80.9%, Dianne Na Penn Reckons with Opus 4.5Host Jacob EffronAnthropic’s head of product for research on computer use, deceptive token prices, thin harnesses, and why alignment makes a model a better thinker.
50:08ENCognitive Revolution "How AI Changes Everything"· Nov 27, 2025Podcast1Mind's AI Superhuman Now Sources 76% of the PipelineHost Nathan LabenzAmanda Kahlow tells Zapier CEO Wade Foster why she tore up the sales org — and why a face on an agent is mostly a trick to get buyers talking.
48:14ENNo Priors: AI, Machine Learning, Tech, & Startups· Nov 13, 2025Podcast · 2 speakersA New Drug Burns $2 Billion and 10 Years. Benchling's CEO Wants AI to Cut That to ThreeHost Sarah Guo, Elad GilMost medicines fail in years seven to ten, after hundreds of millions have already gone into the clinic—and Sajith Wickramasekara thinks sending things to space may already be easier.
27:19ENNo Priors: AI, Machine Learning, Tech, & Startups· Oct 23, 2025Podcast · 2 speakersThe Turing Test Passed. Warp's CEO Says Nobody Seemed to CareHost Sarah Guo, Elad GilZach Lloyd on distilling intelligence without consciousness, why a 40-year-old terminal is the front door for coding agents, and why senior engineers just got more expensive.
44:10ENSequoia Capital· Oct 21, 2025PodcastOne Model Talked Another Into Slack Off — Then Uninstalled Windows DefenderIrregular co-founder Dan Lahav tells Sequoia’s Training Data why frontier AI security has to be invented from scratch as models become autonomous economic actors.
1:37:25ENCognitive Revolution "How AI Changes Everything"· Oct 5, 2025PodcastFin Climbed From 35% to 65% Resolution. Intercom Says the Models Only Did a Few PointsHost Nathan LabenzEoghan McCabe and Fergal Reid on production A/B tests, 99-cent outcome pricing, and why GPT-4 was already smart enough for most customer service.
58:21ENNo Priors: AI, Machine Learning, Tech, & Startups· Oct 4, 2025Podcast · 2 speakersAttacks Take 23 Minutes. Response Still Takes Days.Host Sarah Guo, Elad GilPalo Alto Networks CEO Nikesh Arora on how AI is remaking search, enterprise software, and the timeline of a cyberattack.
59:43ENSequoia Capital· Sep 30, 2025PodcastGoose is writing its own pull requests: how Block is trying to save a quarter of the weekCTO Dhanji Prasanna tells Sequoia how an open-source agent, a functional reorg, and a weekly hours-saved metric are turning Block into an AI-first company.Load moreShowing 24 of 134